PMID- 31352647
OWN - NLM
STAT- MEDLINE
DCOM- 20200205
LR  - 20200225
IS  - 1573-689X (Electronic)
IS  - 0148-5598 (Linking)
VI  - 43
IP  - 9
DP  - 2019 Jul 27
TI  - Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine 
      Without Aura.
PG  - 298
LID - 10.1007/s10916-019-1425-z [doi]
AB  - The aim of this study was to investigate the alterations in regional homogeneity 
      assessed by fMRI in patients with migraine without aura (MWoA). Fifty-six 
      eligible MWoA patients and 32 matched healthy volunteers were enrolled in this 
      study. MWoA patients were divided into three groups according to the headache 
      days per month within 3 months: infrequent episodic migraine (IEM) group, 
      frequent episodic migraine (FEM) group, and chronic migraine (CM) group. Data 
      collection and rest-state fMRI examination were performed in all cases. The ReHo 
      method was used to analyze the blood oxygen level dependent (BLOD) signals of the 
      adjacent voxels in the brain regions of each patient, and the consistency of 
      their fluctuations in the sequences of same time. Compared with normal controls, 
      ReHo values of bilateral thalami, right insula and right middle temporal gyrus 
      increased and both precentral gyri decreased in the IEM group; ReHo values of 
      bilateral thalami and the right middle temporal gyrus increased; ReHo values of 
      both anterior cingulate cortex, precentral gyri and putamen decreased in the FEM 
      group. Compared with control group, ReHo values of left olfactory cortex, right 
      hippocampus, parahippocampal gyrus, suboccipital gyrus and precuneus increased, 
      both precentral gyri, precuneus, putamen and anterior cingulate cortex decreased 
      in the CM group. Compared with IEM group, ReHo values of both putamen, left 
      middle frontal gyrus, right superior frontal gyrus increased, and the left 
      precuneus decreased in the FEM group. Compared with FEM group, ReHo values of 
      left olfactory and left precuneus increased, and the right superior frontal 
      gyrus, insula, middle temporal gyrus, thalami, both superior temporal gyri 
      decreased in the CM group. In the IEM group, the changes of function focus on the 
      regions associated with coding, conduction and regulation of pain signals. In the 
      FEM group, functional alterations mainly concentrated on the regions associated 
      with pain regulation and emotion cognition. In the CM group, the changes focus on 
      the regions related to spatial attention and cognition, affective disorders and 
      pain feedback, which may be associated with migraine production, development and 
      chronification.
FAU - Chen, Can
AU  - Chen C
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Yan, Manyun
AU  - Yan M
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Yu, Yang
AU  - Yu Y
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Ke, Jun
AU  - Ke J
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Xu, Chunyang
AU  - Xu C
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Guo, Xiaoning
AU  - Guo X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Lu, Haifeng
AU  - Lu H
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Wang, Ximing
AU  - Wang X
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Hu, Lan
AU  - Hu L
AD  - Department of Neurology, Ninth People's Hospital of Suzhou, Suzhou, 215200, 
      China.
FAU - Wang, Jingwen
AU  - Wang J
AD  - Department of Neurology, Ninth People's Hospital of Suzhou, Suzhou, 215200, 
      China.
FAU - Ni, Jianqiang
AU  - Ni J
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China.
FAU - Zhao, Hongru
AU  - Zhao H
AD  - Department of Neurology, The First Affiliated Hospital of Soochow University, 
      Suzhou, 215000, China. tiantan11@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190727
PL  - United States
TA  - J Med Syst
JT  - Journal of medical systems
JID - 7806056
SB  - IM
MH  - Adult
MH  - Brain/*diagnostic imaging
MH  - Female
MH  - Functional Neuroimaging
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Male
MH  - Middle Aged
MH  - Migraine without Aura/*pathology
OTO - NOTNLM
OT  - Functional MRI
OT  - Migraine without aura
OT  - Regional homogeneity
OT  - Resting state
EDAT- 2019/07/29 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/07/29 06:00
PHST- 2019/04/26 00:00 [received]
PHST- 2019/07/14 00:00 [accepted]
PHST- 2019/07/29 06:00 [entrez]
PHST- 2019/07/29 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - 10.1007/s10916-019-1425-z [pii]
AID - 10.1007/s10916-019-1425-z [doi]
PST - epublish
SO  - J Med Syst. 2019 Jul 27;43(9):298. doi: 10.1007/s10916-019-1425-z.