PMID- 31352944
OWN - NLM
STAT- MEDLINE
DCOM- 20190801
LR  - 20211204
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 14
IP  - 4
DP  - 2018 Apr 1
TI  - Enhancing the Osteogenic Differentiation and Rapid Osseointegration of 3D Printed 
      Ti6Al4V Implants via Nano-Topographic Modification.
PG  - 707-715
LID - 10.1166/jbn.2018.2551 [doi]
AB  - Personalized precision therapy and rapid osseointegration are the main 
      development directions of dental implants. Three-dimensional (3D) printing is the 
      most promising method to fabricate personalized implants with complex design and 
      structure. Rapid osseointegration guarantees the survival of implants especially 
      at early implant time, and the surface modification via nano-technology is 
      considered as the most effective method to promote osseointegration. Herein, the 
      Ti6Al4V implants were fabricated by 3D-printing method then the nano-topographic 
      surface was constructed on them to improve the biological responses. The results 
      showed that the nano-topographic modification favored the adhesion and osteogenic 
      differentiation of bone marrow derived mesenchymal stromal cells (BMSCs), 
      accelerating the rapid osseointegration in vivo in rat condyle of femur model. It 
      is reasonable to predict that 3D-printed implants with nano-topographic surface 
      modification have a promising future in orthopedic applications.
FAU - Wang, Hui
AU  - Wang H
FAU - Zhang, Xinran
AU  - Zhang X
FAU - Wang, Haicheng
AU  - Wang H
FAU - Zhang, Jinkai
AU  - Zhang J
FAU - Li, Jia
AU  - Li J
FAU - Ruan, Changshun
AU  - Ruan C
FAU - Zhu, Rui
AU  - Zhu R
FAU - Lin, Kaili
AU  - Lin K
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
RN  - 0 (Alloys)
RN  - 12743-70-3 (titanium alloy (TiAl6V4))
RN  - D1JT611TNE (Titanium)
SB  - IM
MH  - Alloys
MH  - Animals
MH  - *Osseointegration
MH  - *Osteogenesis
MH  - Printing, Three-Dimensional
MH  - Rats
MH  - Surface Properties
MH  - Titanium
EDAT- 2018/04/01 00:00
MHDA- 2019/08/02 06:00
CRDT- 2019/07/30 06:00
PHST- 2019/07/30 06:00 [entrez]
PHST- 2018/04/01 00:00 [pubmed]
PHST- 2019/08/02 06:00 [medline]
AID - 10.1166/jbn.2018.2551 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2018 Apr 1;14(4):707-715. doi: 10.1166/jbn.2018.2551.