PMID- 31352946
OWN - NLM
STAT- MEDLINE
DCOM- 20190801
LR  - 20190801
IS  - 1550-7033 (Print)
IS  - 1550-7033 (Linking)
VI  - 14
IP  - 4
DP  - 2018 Apr 1
TI  - Composite Polyelectrolyte Multilayer and Mesoporous Bioactive Glass Nanoparticle 
      Coating on 316L Stainless Steel for Controlled Antibiotic Release and 
      Biocompatibility.
PG  - 725-735
LID - 10.1166/jbn.2018.2531 [doi]
AB  - Bacterial infection in wounds or implants can cause osteomyelitis, eventually 
      leading to orthopedic implant failure. In this study, polyelectrolyte multilayer 
      (PEM) coating comprising collagen as the cationic layer, chitosan as the barrier 
      layer and gamma-poly-glutamic acid as the anionic layer were fabricated onto a 316L 
      stainless steel substrate by spin coating technique. Tetracycline-loaded 57S 
      mesoporous bioactive glass nanoparticles (57S MBG, SiO(2):CaO:P(2)O(5) = 57:33:10 by 
      wt%) were introduced into the gamma-poly-glutamic acid layers. Herein, 57S MBG 
      nanoparticles were successfully incorporated into the PEMs with a total thickness 
      of  approximately 53 mum on 316L stainless steel (SS-PEMs-57S), which exhibited good 
      hydrophilicity with a contact angle of 18.71 degrees . The hardness of SS-PEMs-57S was 
      0.66 GPa while the Young's modulus was 11.5 GPa; these values are similar to 
      those for the cortical bone. The surface roughness of MBG 
      nanoparticle-incorporated PEMs increased from 231 to 384 nm. Controlled release 
      of tetracycline loaded in MBG nanoparticles resulted in sustained antibacterial 
      effect for up to 7 days, with higher release efficacy at low pH, which may be 
      induced by inflammation or infection. Tetracycline loaded in SS-PEMs-57S showed 
      good bacterial inhibition and maintained good cell viability in rat bone marrow 
      mesenchymal stem cells (BMSCs) in the MTT assay. Moreover, SS-PEMs-57S also 
      promoted mineralization of BMSCs. Therefore, this surface modification technology 
      has great potential for endowing orthopedic implants with antibacterial and 
      osteoconductive properties.
FAU - Liu, Xinrui
AU  - Liu X
FAU - Chen, Hsiang-Ho
AU  - Chen HH
FAU - Lin, Yu-Chien
AU  - Lin YC
FAU - Nabilla, Sasza Chyntara
AU  - Nabilla SC
FAU - Liu, Wai-Ching
AU  - Liu WC
FAU - Wang, Wen-Chi
AU  - Wang WC
FAU - Shih, Shao-Ju
AU  - Shih SJ
FAU - Li, Yunqian
AU  - Li Y
FAU - Lin, Ching-Po
AU  - Lin CP
FAU - Zhao, Gang
AU  - Zhao G
FAU - Chung, Ren-Jei
AU  - Chung RJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Biomed Nanotechnol
JT  - Journal of biomedical nanotechnology
JID - 101230869
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Polyelectrolytes)
RN  - 12597-68-1 (Stainless Steel)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Anti-Bacterial Agents
MH  - *Nanoparticles
MH  - *Polyelectrolytes
MH  - Rats
MH  - Silicon Dioxide
MH  - Stainless Steel
MH  - Surface Properties
EDAT- 2018/04/01 00:00
MHDA- 2019/08/02 06:00
CRDT- 2019/07/30 06:00
PHST- 2019/07/30 06:00 [entrez]
PHST- 2018/04/01 00:00 [pubmed]
PHST- 2019/08/02 06:00 [medline]
AID - 10.1166/jbn.2018.2531 [doi]
PST - ppublish
SO  - J Biomed Nanotechnol. 2018 Apr 1;14(4):725-735. doi: 10.1166/jbn.2018.2531.