PMID- 31353652
OWN - NLM
STAT- MEDLINE
DCOM- 20200612
LR  - 20200612
IS  - 1745-4514 (Electronic)
IS  - 0145-8884 (Linking)
VI  - 43
IP  - 2
DP  - 2019 Feb
TI  - Aqueous extract of berry (Plinia jaboticaba) byproduct modulates gut microbiota 
      and maintains the balance on antioxidant defense system in rats.
PG  - e12705
LID - 10.1111/jfbc.12705 [doi]
AB  - Previous studies have assessed the properties of aqueous extracts, using 
      byproducts such as jaboticaba peel. We have assessed potential antioxidant 
      effects of jaboticaba extract (Plinia jaboticaba) (JAE = 50 g/L) in vitro and in 
      vivo. Healthy Wistar rats received ad libitum JAE for either 15 or 49 days in 
      vivo. Cyanidin-3-O-glucoside, delphinidin-3-O-glucoside, gallic acid, rutin, 
      myricetin, and quercetin were identified as the main polyphenols in JAE. Lipid 
      peroxidation values in the serum and colon were similar throughout the groups. In 
      addition, JAE did not disturb the antioxidant systems. JAE also altered gut 
      microbiota, increasing since Lactobacillus, Bifidobacterium and 
      Enterobacteriaceae counts. Bacterial metabolites were higher in the colon content 
      of rats fed with JAE than in the control group. Given these results, under 
      healthy conditions, JAE dietary supplementation could perform in vivo modulation 
      of gut microbiota, without disturbing the antioxidant system. PRACTICAL 
      APPLICATION: Jaboticaba (Plinia jaboticaba) peel is a rich and often-wasted 
      source of bioactive compounds, such as polyphenols. Previous studies have shown 
      that physiological benefits of this berry. The jaboticaba peel could contribute 
      to antioxidant defense systems; it may also have an effect over gut microbiota 
      related to polyphenols contents. Aqueous extraction may be a practical way of 
      employing the bioactive compounds of jaboticaba peel; these compounds can be 
      consumed daily and safely, and thus have attracted particular attention. This 
      work showed positive impacts of jaboticaba peel treatments on microbiota and 
      antioxidant defense systems, and could guide future clinical studies.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - da Silva-Maia, Juliana Kelly
AU  - da Silva-Maia JK
AUID- ORCID: 0000-0002-7970-534X
AD  - Faculty of Food Engineering, Department of Food and Nutrition, University of 
      Campinas (UNICAMP), Campinas, Brazil.
FAU - Batista, Angela Giovana
AU  - Batista AG
AD  - Faculty of Food Engineering, Department of Food and Nutrition, University of 
      Campinas (UNICAMP), Campinas, Brazil.
AD  - Department of Food and Nutrition, Federal University of Santa Maria (UFSM, Campus 
      Palmeira das Missoes), Palmeira das Missoes, Brazil.
FAU - Correa, Luiz Claudio
AU  - Correa LC
AD  - Brazilian Agricultural Research Corporation, Embrapa Tropical Semi-arid, 
      Petrolina, Brazil.
FAU - Lima, Glaucia Carielo
AU  - Lima GC
AD  - Faculty of Food Engineering, Department of Food and Nutrition, University of 
      Campinas (UNICAMP), Campinas, Brazil.
AD  - Faculty of Nutrition, Federal University of Goias (UFG), Goiania, Brazil.
FAU - Bogusz Junior, Stanislau
AU  - Bogusz Junior S
AD  - Sao Carlos Institute of Chemistry (IQSC), University of Sao Paulo (USP), Sao 
      Carlos, Brazil.
FAU - Marostica Junior, Mario Roberto
AU  - Marostica Junior MR
AD  - Faculty of Food Engineering, Department of Food and Nutrition, University of 
      Campinas (UNICAMP), Campinas, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20181111
PL  - United States
TA  - J Food Biochem
JT  - Journal of food biochemistry
JID - 7706045
RN  - 0 (Antioxidants)
RN  - 0 (Plant Extracts)
RN  - 0 (Waste Products)
SB  - IM
MH  - Animal Feed/analysis
MH  - Animals
MH  - Antioxidants/*metabolism
MH  - Bacteria/classification/drug effects/genetics/isolation & purification
MH  - Colon/drug effects/metabolism/microbiology
MH  - Fruit/chemistry
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Male
MH  - Myrtaceae/*chemistry
MH  - Plant Extracts/chemistry/isolation & purification/*pharmacology
MH  - Rats
MH  - Rats, Wistar
MH  - Waste Products/*analysis
OTO - NOTNLM
OT  - Myrtaceae
OT  - free radical
OT  - functional food
OT  - infusion
OT  - jaboticaba
OT  - short-chain fatty acids
EDAT- 2019/07/30 06:00
MHDA- 2020/06/13 06:00
CRDT- 2019/07/30 06:00
PHST- 2018/02/14 00:00 [received]
PHST- 2018/08/16 00:00 [revised]
PHST- 2018/09/13 00:00 [accepted]
PHST- 2019/07/30 06:00 [entrez]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2020/06/13 06:00 [medline]
AID - 10.1111/jfbc.12705 [doi]
PST - ppublish
SO  - J Food Biochem. 2019 Feb;43(2):e12705. doi: 10.1111/jfbc.12705. Epub 2018 Nov 11.