PMID- 31354894
OWN - NLM
STAT- MEDLINE
DCOM- 20191227
LR  - 20211204
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2019
DP  - 2019
TI  - Assessment of the Concentration of Bone Metabolism Markers: Sclerostin and FGF-23 
      in Children with Idiopathic Nephrotic Syndrome Treated with Glucocorticosteroids.
PG  - 9698367
LID - 10.1155/2019/9698367 [doi]
LID - 9698367
AB  - Recurring nature of idiopathic nephrotic syndrome (INS) and steroid dependence 
      imply a long-term treatment with glucocorticosteroids (GCSs), which increases the 
      risk of bone metabolism disorders. The search for new markers of that process is 
      essential. The aims of this study were to assess the concentrations of sclerostin 
      (Scl) and fibroblast growth factor-23 (FGF-23) in the plasma of children with INS 
      and compare Scl and FGF-23 to existing markers of bone metabolism, mainly 
      parathyroid hormone (PTH). The study involved 70 children, 50 with INS and 20 
      healthy children. Patients with INS were divided into 4 groups depending on the 
      number of relapses and applied therapy. Significantly higher concentrations of 
      FGF-23 and Scl were found in all patient groups with INS compared to the control 
      group, and increase in the concentrations of examined parameters depending on the 
      number of NS relapses was showed. In patients from the group with numerous 
      relapses, higher concentrations of FGF-23 and Scl in the relapse phase than those 
      in the remission phase were found. We observed positive correlation in these 
      proteins with parathyroid hormone. Positive correlation of FGF-23 and Scl in the 
      examined group was noted. Children having relapsing INS treated with steroids 
      have higher levels of Scl and FGF-23 that can indicate the bone metabolism 
      disorders. The significance of these observations requires further research.
FAU - Pukajlo-Marczyk, Agnieszka
AU  - Pukajlo-Marczyk A
AUID- ORCID: 0000-0001-8750-7389
AD  - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 
      Wroclaw 50-556, Poland.
FAU - Jakubowska, Anna
AU  - Jakubowska A
AUID- ORCID: 0000-0002-7732-3487
AD  - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 
      Wroclaw 50-556, Poland.
FAU - Bargenda-Lange, Agnieszka
AU  - Bargenda-Lange A
AUID- ORCID: 0000-0003-3048-4547
AD  - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 
      Wroclaw 50-556, Poland.
FAU - Kilis-Pstrusinska, Katarzyna
AU  - Kilis-Pstrusinska K
AUID- ORCID: 0000-0001-7352-6992
AD  - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 
      Wroclaw 50-556, Poland.
FAU - Zwolinska, Danuta
AU  - Zwolinska D
AUID- ORCID: 0000-0002-6714-3992
AD  - Department of Pediatric Nephrology, Wroclaw Medical University, Borowska 213, 
      Wroclaw 50-556, Poland.
LA  - eng
PT  - Journal Article
DEP - 20190701
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Adrenal Cortex Hormones)
RN  - 0 (Biomarkers)
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (FGF23 protein, human)
RN  - 0 (Genetic Markers)
RN  - 0 (SOST protein, human)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 7Q7P4S7RRE (Fibroblast Growth Factor-23)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Adrenal Cortex Hormones/*adverse effects/therapeutic use
MH  - Biomarkers/blood
MH  - Bone Diseases, Metabolic/*blood/etiology
MH  - Bone Morphogenetic Proteins/*blood
MH  - Child
MH  - Female
MH  - Fibroblast Growth Factor-23
MH  - Fibroblast Growth Factors/*blood
MH  - Genetic Markers
MH  - Humans
MH  - Male
MH  - Nephrotic Syndrome/complications/*drug therapy
PMC - PMC6636590
EDAT- 2019/07/30 06:00
MHDA- 2019/12/28 06:00
PMCR- 2019/07/01
CRDT- 2019/07/30 06:00
PHST- 2018/09/25 00:00 [received]
PHST- 2019/01/18 00:00 [revised]
PHST- 2019/03/18 00:00 [accepted]
PHST- 2019/07/30 06:00 [entrez]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2019/12/28 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 10.1155/2019/9698367 [doi]
PST - epublish
SO  - Dis Markers. 2019 Jul 1;2019:9698367. doi: 10.1155/2019/9698367. eCollection 
      2019.