PMID- 31355160
OWN - NLM
STAT- MEDLINE
DCOM- 20200326
LR  - 20200326
IS  - 2291-2797 (Electronic)
IS  - 2291-2789 (Print)
IS  - 2291-2789 (Linking)
VI  - 2019
DP  - 2019
TI  - Clinical Significance of Prothrombin Time in Cholangiocarcinoma Patients with 
      Surgeries.
PG  - 3413969
LID - 10.1155/2019/3413969 [doi]
LID - 3413969
AB  - BACKGROUND: Prothrombin time (PT) can predict survival in several types of 
      malignancies. This study aims to investigate the predictive values of PT levels 
      in patients with cholangiocarcinoma (CCA). METHODS: We retrospectively analyzed 
      the PT from 86 CCA patients who underwent curative resection in our hospital from 
      December 2008 to August 2017. The relationship between PT and survival times was 
      analyzed through univariate and multivariate analyses (Cox proportional hazards 
      model). Kaplan-Meier curves and log-rank test were used to assess the effects of 
      PT on overall survival (OS) and tumor recurrence-free survival (RFS). RESULTS: 
      Increased PT level was an effective predictor for OS (P = 0.021; hazard ratio 
      (HR), 1.799) and RFS (P = 0.016; HR, 1.871) in CCA patients, independent of age, 
      tumor differentiation, and TNM stage. In the low PT level group (PT < 12.3 s), 
      patients showed a higher mean OS (23.03 m vs. 14.38 m, P = 0.0250) and RFS (17.78 
      m vs. 8.30 m, P = 0.0511) than those with high PT levels (PT >/= 12.3 s). A highly 
      significant association was observed between high PT level and shortened OS (P = 
      0.0373) and worse RFS (P = 0.0151). CONCLUSION: Preoperative increase in PT can 
      serve as a simple but effective predictor of poor survival in CCA patients who 
      undergo curative surgeries.
FAU - Wang, Hui-Shan
AU  - Wang HS
AD  - Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 
      211166, Jiangsu Province, China.
FAU - Ge, Xian-Xiu
AU  - Ge XX
AD  - Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing 
      Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China.
FAU - Li, Quan-Peng
AU  - Li QP
AD  - Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing 
      Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China.
FAU - Nie, Jun-Jie
AU  - Nie JJ
AD  - Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing 
      Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China.
FAU - Miao, Lin
AU  - Miao L
AUID- ORCID: 0000-0002-1114-0530
AD  - Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing 
      211166, Jiangsu Province, China.
AD  - Medical Center for Digestive Diseases, The Second Affiliated Hospital of Nanjing 
      Medical University, 121 Jiangjiayuan, Nanjing 210011, Jiangsu Province, China.
LA  - eng
PT  - Journal Article
DEP - 20190701
PL  - Egypt
TA  - Can J Gastroenterol Hepatol
JT  - Canadian journal of gastroenterology & hepatology
JID - 101623613
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Bile Duct Neoplasms/pathology/*surgery
MH  - Cholangiocarcinoma/pathology/*surgery
MH  - Disease-Free Survival
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Predictive Value of Tests
MH  - Preoperative Period
MH  - *Prothrombin Time
MH  - Retrospective Studies
MH  - Survival Rate
PMC - PMC6634076
EDAT- 2019/07/30 06:00
MHDA- 2020/03/27 06:00
PMCR- 2019/07/01
CRDT- 2019/07/30 06:00
PHST- 2019/01/03 00:00 [received]
PHST- 2019/04/25 00:00 [revised]
PHST- 2019/05/06 00:00 [accepted]
PHST- 2019/07/30 06:00 [entrez]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2020/03/27 06:00 [medline]
PHST- 2019/07/01 00:00 [pmc-release]
AID - 10.1155/2019/3413969 [doi]
PST - epublish
SO  - Can J Gastroenterol Hepatol. 2019 Jul 1;2019:3413969. doi: 10.1155/2019/3413969. 
      eCollection 2019.