PMID- 31355420
OWN - NLM
STAT- MEDLINE
DCOM- 20200828
LR  - 20240216
IS  - 1600-0447 (Electronic)
IS  - 0001-690X (Print)
IS  - 0001-690X (Linking)
VI  - 140
IP  - 4
DP  - 2019 Oct
TI  - Does hallucination perceptual modality impact psychosis risk?
PG  - 360-370
LID - 10.1111/acps.13078 [doi]
AB  - OBJECTIVE: Subthreshold perceptual abnormalities are commonly used to identify 
      individuals at clinical high risk (CHR) for developing a psychotic disorder. 
      Predictive validity for modality-specific perceptual abnormality severity on 
      psychosis risk is unknown. METHODS: We examined prospectively collected data from 
      164 individuals age 12-35 meeting criteria for CHR followed for 6-24 months or 
      until conversion to psychosis. Using intake interview notes, baseline perceptual 
      abnormality scores were split into auditory, visual, somatic/tactile, and 
      olfactory/gustatory components, and auditory scores were further split into those 
      for verbal vs non-verbal content. Relationships between perceptual abnormality 
      characteristics and conversion were assessed with Cox proportional hazards 
      regression and logistic regression. RESULTS: Unusual thought content and paranoia 
      were predictive of conversion, but no modality-specific perceptual abnormality 
      score predicted conversion status or days to conversion. However, when auditory 
      perceptual abnormalities were further categorized as verbal vs non-verbal, the 
      severity of verbal experiences was predictive of conversion to psychosis 
      (P = 0.007). CONCLUSIONS: Perceptual abnormality scores failed to meaningfully 
      predict conversion to psychosis in either direction in this CHR sample. However, 
      verbal auditory experiences may identify a group of CHR individuals at elevated 
      risk of conversion. Further exploration of the relationship between 
      phenomenological aspects of perceptual abnormalities and conversion risk is 
      warranted.
CI  - (c) 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
FAU - Niles, H F
AU  - Niles HF
AD  - Department of Psychiatry and the Connecticut Mental Health Center, Yale 
      University, New Haven, CT, USA.
FAU - Walsh, B C
AU  - Walsh BC
AD  - Department of Psychiatry and the Connecticut Mental Health Center, Yale 
      University, New Haven, CT, USA.
FAU - Woods, S W
AU  - Woods SW
AD  - Department of Psychiatry and the Connecticut Mental Health Center, Yale 
      University, New Haven, CT, USA.
FAU - Powers, A R 3rd
AU  - Powers AR 3rd
AUID- ORCID: 0000-0003-3057-5043
AD  - Department of Psychiatry and the Connecticut Mental Health Center, Yale 
      University, New Haven, CT, USA.
LA  - eng
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - K23 MH115252/MH/NIMH NIH HHS/United States
GR  - U01 MH066160/MH/NIMH NIH HHS/United States
GR  - WT_/Wellcome Trust/United Kingdom
GR  - T35 AA023760/AA/NIAAA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190816
PL  - United States
TA  - Acta Psychiatr Scand
JT  - Acta psychiatrica Scandinavica
JID - 0370364
SB  - IM
MH  - Adolescent
MH  - Case-Control Studies
MH  - Child
MH  - Female
MH  - Hallucinations/complications/*psychology
MH  - Humans
MH  - Male
MH  - Paranoid Disorders/diagnosis/psychology
MH  - Perception/*physiology
MH  - Perceptual Disorders/*psychology
MH  - Predictive Value of Tests
MH  - Prodromal Symptoms
MH  - Psychotic Disorders/diagnosis/ethnology/*psychology
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Severity of Illness Index
MH  - Young Adult
PMC - PMC6752971
MID - NIHMS1043817
OTO - NOTNLM
OT  - clinical high risk
OT  - hallucinations
OT  - prodrome
OT  - psychosis
COIS- The authors have no conflicts of interest to report.
EDAT- 2019/07/30 06:00
MHDA- 2020/08/29 06:00
PMCR- 2020/10/01
CRDT- 2019/07/30 06:00
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2020/08/29 06:00 [medline]
PHST- 2019/07/30 06:00 [entrez]
PHST- 2020/10/01 00:00 [pmc-release]
AID - 10.1111/acps.13078 [doi]
PST - ppublish
SO  - Acta Psychiatr Scand. 2019 Oct;140(4):360-370. doi: 10.1111/acps.13078. Epub 2019 
      Aug 16.