PMID- 31355638
OWN - NLM
STAT- MEDLINE
DCOM- 20191128
LR  - 20191128
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Linking)
VI  - 53
IP  - 16
DP  - 2019 Aug 20
TI  - Associations between Exposure to Persistent Organic Pollutants and Thyroid 
      Function in a Case-Control Study of East China.
PG  - 9866-9875
LID - 10.1021/acs.est.9b02810 [doi]
AB  - Animal studies have indicated that persistent organic pollutants (POPs) affect 
      thyroid hormone homeostasis, while epidemiological studies involving human have 
      not shown consistent results. In this study, we investigated the associations 
      between POP exposure and thyroid function among adult population of East China. 
      One hundred eighty-six participants diagnosed with thyroid disease and 186 
      participants without thyroid disease from Shandong, China were enrolled in the 
      case-control study during 2016 to 2017. We found that POP exposure was 
      significantly and positively associated with the risk of thyroid disease. The 
      association of thyroid disease with a sum of 17 POPs followed a nonmonotonic dose 
      response, with an adjusted odds ratio of 2.09 (95% confidence intervals: 
      1.13-3.87, p = 0.019) for the second quartile. Among 186 participants in the 
      control group, concentrations of POPs showed negative associations with 
      triiodothyronine (T3), free T3 (FT3), thyroxine (T4), and free T4 (FT4) in males 
      and positive associations with T4 and FT4 in females. Taken together, these 
      findings suggest that POP exposure can disrupt thyroid hormone homeostasis and 
      increase the risk of thyroid disease.
FAU - Han, Xu
AU  - Han X
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
AD  - University of Chinese Academy of Sciences , Beijing 100049 , China.
FAU - Meng, Lingling
AU  - Meng L
AD  - Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with 
      Shandong First Medical University , Jinan 250014 , China.
FAU - Li, Yingming
AU  - Li Y
AUID- ORCID: 0000-0003-4261-9744
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
FAU - Li, An
AU  - Li A
AUID- ORCID: 0000-0002-8476-8783
AD  - School of Public Health , University of Illinois at Chicago , Chicago , Illinois 
      60612 , United States.
FAU - Turyk, Mary E
AU  - Turyk ME
AD  - School of Public Health , University of Illinois at Chicago , Chicago , Illinois 
      60612 , United States.
FAU - Yang, Ruiqiang
AU  - Yang R
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
FAU - Wang, Pu
AU  - Wang P
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
FAU - Xiao, Ke
AU  - Xiao K
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
FAU - Li, Wenjuan
AU  - Li W
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
FAU - Zhao, Junpeng
AU  - Zhao J
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
AD  - University of Chinese Academy of Sciences , Beijing 100049 , China.
FAU - Zhang, Qinghua
AU  - Zhang Q
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
AD  - University of Chinese Academy of Sciences , Beijing 100049 , China.
FAU - Jiang, Guibin
AU  - Jiang G
AUID- ORCID: 0000-0002-6335-3917
AD  - State Key Laboratory of Environmental Chemistry and Ecotoxicology , Research 
      Center for Eco-Environmental Sciences, Chinese Academy of Sciences , Beijing 
      100085 , China.
AD  - University of Chinese Academy of Sciences , Beijing 100049 , China.
LA  - eng
PT  - Journal Article
DEP - 20190809
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 0 (Environmental Pollutants)
RN  - 9002-71-5 (Thyrotropin)
RN  - Q51BO43MG4 (Thyroxine)
SB  - IM
MH  - Adult
MH  - Animals
MH  - Case-Control Studies
MH  - China
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - Male
MH  - Thyroid Gland
MH  - *Thyrotropin
MH  - Thyroxine
EDAT- 2019/07/30 06:00
MHDA- 2019/11/30 06:00
CRDT- 2019/07/30 06:00
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2019/11/30 06:00 [medline]
PHST- 2019/07/30 06:00 [entrez]
AID - 10.1021/acs.est.9b02810 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2019 Aug 20;53(16):9866-9875. doi: 10.1021/acs.est.9b02810. 
      Epub 2019 Aug 9.