PMID- 31356099
OWN - NLM
STAT- MEDLINE
DCOM- 20200922
LR  - 20200922
IS  - 1735-3947 (Electronic)
IS  - 1029-2977 (Linking)
VI  - 22
IP  - 6
DP  - 2019 Jun 1
TI  - Dietary Total Antioxidant Capacity and Risk of Gastrointestinal Cancers: A 
      Systematic Review and Meta-analysis of Observational Studies.
PG  - 328-335
AB  - BACKGROUND: Gastrointestinal (GI) cancers are common types of cancers. Among 
      different factors that affect the etiology of GI cancers, diet has an important 
      contribution. Dietary antioxidants decrease oxidative stress which plays a 
      pivotal role in carcinogenesis. Several studies assessed the relation between 
      dietary total antioxidant capacity (TAC) and risk of GI cancers. Dietary TAC was 
      measured by three indices including FRAP (ferric ion reducing antioxidant power), 
      TRAP (total radical-trapping antioxidant parameter), and TEAC (trolox equivalent 
      antioxidant capacity). We performed a systematic review and meta-analysis of 
      published studies to determine the association between dietary TAC and GI cancers 
      risk. METHODS: Eligible studies were selected from PubMed, ISI Web of Science and 
      Scopus databases from inception until May 2018. Case-control and cohort studies 
      that reported GI cancer risk estimates for dietary TAC were included. We ignored 
      the distinction between case-control and cohort studies. We applied 
      random-effects to estimate pooled relative risks. Subgroup analysis was done 
      based on study design. RESULTS: Among the seven observational studies that were 
      included, four were cohort studies and three were case-control studies. Dietary 
      FRAP, TRAP, and TEAC reduced GI cancer risk: FRAP; 0.71; 95% CI: 0.58-0.85, TRAP; 
      0.65; 95% CI: 0.57-0.75, TEAC; 0.70; 95% CI: 0.59-0.83, respectively. CONCLUSION: 
      This study indicated that dietary TAC significantly decreased the risk of GI 
      cancers. Nevertheless, further prospective studies are required to clarify the 
      association between dietary TAC and risk of GI cancers.
CI  - (c) 2019 The Author(s). This is an open-access article distributed under the terms 
      of the Creative Commons Attribution License 
      (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, 
      distribution, and reproduction in any medium, provided the original work is 
      properly cited.
FAU - Zamani, Behzad
AU  - Zamani B
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Students' Scientific Research Center (SSRC), Tehran University of Medical 
      Sciences (TUMS), Tehran, Iran.
FAU - Daneshzad, Elnaz
AU  - Daneshzad E
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
FAU - Azadbakht, Leila
AU  - Azadbakht L
AUID- ORCID: 0000-0002-5955-6818
AD  - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, 
      Tehran University of Medical Sciences, Tehran, Iran.
AD  - Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences 
      Institute, Tehran University of Medical Sciences, Tehran, Iran.
AD  - Department of Community Nutrition, School of Nutrition and Food Science, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20190601
PL  - Iran
TA  - Arch Iran Med
JT  - Archives of Iranian medicine
JID - 100889644
RN  - 0 (Antioxidants)
SB  - IM
MH  - Antioxidants/*administration & dosage
MH  - *Diet
MH  - Gastrointestinal Neoplasms/*epidemiology
MH  - Humans
MH  - Observational Studies as Topic
MH  - Risk
OTO - NOTNLM
OT  - Cancer risk
OT  - Dietary total antioxidant capacity
OT  - FRAP
OT  - Gastrointestinal cancers
OT  - TEAC
OT  - TRAP
EDAT- 2019/07/30 06:00
MHDA- 2020/09/23 06:00
CRDT- 2019/07/30 06:00
PHST- 2018/08/02 00:00 [received]
PHST- 2019/04/07 00:00 [accepted]
PHST- 2019/07/30 06:00 [entrez]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2020/09/23 06:00 [medline]
AID - S1029-2977-22(06)328-0 [pii]
PST - epublish
SO  - Arch Iran Med. 2019 Jun 1;22(6):328-335.