PMID- 3135702
OWN - NLM
STAT- MEDLINE
DCOM- 19880908
LR  - 20190903
IS  - 0001-6632 (Print)
IS  - 0001-6632 (Linking)
VI  - 38
IP  - 4
DP  - 1988 Apr
TI  - An autopsy case of diffuse myelomatosis associated with systemic kappa light 
      chain deposition disease (LCDD). A patho-anatomical, immunohistochemical and 
      immunobiochemical study.
PG  - 479-88
AB  - A case of systemic light chain deposition disease in a 48-year-old man is 
      presented. Clinically, the patient showed the signs of multiple organ (liver, 
      heart and kidney) failure, but multiple myeloma was not diagnosed. Autopsy 
      revealed generalized deposition of hyaline, a Congo red-negative substance, 
      especially in the arterial walls of various organs. In the bone marrow, 
      myelomatous proliferations of plasma cells positive for kappa light chain were 
      recognized. The deposited substance was ultrastructurally different from amyloid 
      fibrils, and was identified as kappa light chain by immunohistochemistry. A liver 
      tissue extract was immunobiochemically examined and the deposited substance was 
      confirmed to consist of kappa light chain, its molecular weight being 
      approximately 14,000 to 17,000 Da.
FAU - Toyoda, M
AU  - Toyoda M
AD  - Department of Pathology, Tokyo Women's Medical College, Japan.
FAU - Kajita, A
AU  - Kajita A
FAU - Kita, S
AU  - Kita S
FAU - Osamura, Y
AU  - Osamura Y
FAU - Shinoda, T
AU  - Shinoda T
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Australia
TA  - Acta Pathol Jpn
JT  - Acta pathologica japonica
JID - 0372637
RN  - 0 (Immunoglobulin Light Chains)
SB  - IM
MH  - Autopsy
MH  - Bile Ducts/analysis/pathology
MH  - Bone Marrow/analysis/pathology
MH  - Humans
MH  - Hypergammaglobulinemia/diagnosis/*pathology
MH  - Immunoenzyme Techniques
MH  - Immunoglobulin Light Chains/*analysis
MH  - Kidney/analysis/pathology
MH  - Male
MH  - Middle Aged
MH  - Multiple Myeloma/diagnosis/*pathology
MH  - Myocardium/analysis/pathology
MH  - Spleen/analysis/pathology
EDAT- 1988/04/01 00:00
MHDA- 1988/04/01 00:01
CRDT- 1988/04/01 00:00
PHST- 1988/04/01 00:00 [pubmed]
PHST- 1988/04/01 00:01 [medline]
PHST- 1988/04/01 00:00 [entrez]
AID - 10.1111/j.1440-1827.1988.tb02321.x [doi]
PST - ppublish
SO  - Acta Pathol Jpn. 1988 Apr;38(4):479-88. doi: 10.1111/j.1440-1827.1988.tb02321.x.