PMID- 31357205
OWN - NLM
STAT- MEDLINE
DCOM- 20200512
LR  - 20221207
IS  - 1423-0313 (Electronic)
IS  - 0031-7012 (Linking)
VI  - 104
IP  - 5-6
DP  - 2019
TI  - The Matrine Derivate MASM Inhibits Recruitment of Gr1hi Monocyte and Alleviates 
      Liver Injury.
PG  - 235-243
LID - 10.1159/000501384 [doi]
AB  - BACKGROUNDS: (6aS, 10S, 11aR, 11bR, 11cS)-10-methylaminododecahydro-3a, 
      7a-diaza-benzo (de) anthracene-8-thione (MASM), a novel derivative of matrine, 
      exhibits better anti-inflammatory activity. This study was designed to evaluate 
      the protective effect of MASM on acute and chronic liver injuries and explore the 
      possible mechanisms. METHODS: Acute and chronic liver injury models were 
      established by the CCl4 intraperitoneal injection and the protective effect of 
      MASM was assessed by biochemical and histological examination. The infiltration 
      of different monocyte subsets into the liver was characterized and analyzed by 
      flow cytometry. The in vitro effect of MASM on liver nonparenchymal cells was 
      evaluated by real-time PCR and transwell chemotaxis assays. RESULTS: 
      Administration of MASM markedly attenuated acute liver injury and liver fibrosis 
      induced by CCl4 injection. Meanwhile, the infiltrations of Gr1hi monocytes in 
      injured livers and induced hepatic expression of monocyte chemoattractant 
      protein-1 (MCP-1) were greatly inhibited. Cellular experiments demonstrated that 
      MASM not only decreased the expression of MCP-1 but also inhibited its 
      chemotactic activity. CONCLUSIONS: This study demonstrates that the protective 
      effect of MASM on liver injury could be contributed to the suppression of Gr1hi 
      monocyte infiltration to the liver and the inhibition of MCP-1 production and 
      activity. These findings provide new insights into the protective role of MASM in 
      liver injury.
CI  - (c) 2019 S. Karger AG, Basel.
FAU - Xu, Wei-Heng
AU  - Xu WH
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China.
FAU - Xu, Jing
AU  - Xu J
AD  - Department of Pharmacy, Shanghai East Hospital, Tongji University, Shanghai, 
      China.
FAU - Xie, Fang-Yuan
AU  - Xie FY
AD  - Department of Pharmacy, Shanghai Eastern Hepatobiliary Surgery Hospital, 
      Shanghai, China.
FAU - Li, Ying-Hua
AU  - Li YH
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China.
FAU - Hu, Zhen-Lin
AU  - Hu ZL
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China.
FAU - Zhang, Jin-Jin
AU  - Zhang JJ
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China.
FAU - Lu, Bin
AU  - Lu B
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China.
FAU - Zhang, Jun-Ping
AU  - Zhang JP
AD  - School of Pharmacy, Second Military Medical University, Shanghai, China, 
      jpzhang08@163.com.
LA  - eng
PT  - Journal Article
DEP - 20190729
PL  - Switzerland
TA  - Pharmacology
JT  - Pharmacology
JID - 0152016
RN  - 0 (Alkaloids)
RN  - 0 (Anthracenes)
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antigens, Ly)
RN  - 0 (Ccl2 protein, mouse)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Ly6G antigen, mouse)
RN  - 0 (Quinolizines)
RN  - 0 (Thiones)
RN  - 0 (matrine derivate masm)
RN  - CL2T97X0V0 (Carbon Tetrachloride)
RN  - 0 (Matrines)
SB  - IM
MH  - Alkaloids/pharmacology/*therapeutic use
MH  - Animals
MH  - Anthracenes/*pharmacology/therapeutic use
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Antigens, Ly/immunology
MH  - Carbon Tetrachloride
MH  - Chemical and Drug Induced Liver Injury/*drug therapy/immunology/pathology
MH  - Chemokine CCL2/immunology
MH  - Liver/drug effects/immunology/pathology
MH  - Liver Cirrhosis/*drug therapy/immunology/pathology
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Monocytes/*drug effects/immunology
MH  - Quinolizines/pharmacology/*therapeutic use
MH  - Thiones/*pharmacology/therapeutic use
MH  - Matrines
OTO - NOTNLM
OT  - Gr1hi monocyte
OT  - Liver injury
OT  - Matrine derivatives
OT  - Monocyte chemoattractant protein-1
EDAT- 2019/07/30 06:00
MHDA- 2020/05/19 06:00
CRDT- 2019/07/30 06:00
PHST- 2019/03/21 00:00 [received]
PHST- 2019/06/07 00:00 [accepted]
PHST- 2019/07/30 06:00 [pubmed]
PHST- 2020/05/19 06:00 [medline]
PHST- 2019/07/30 06:00 [entrez]
AID - 000501384 [pii]
AID - 10.1159/000501384 [doi]
PST - ppublish
SO  - Pharmacology. 2019;104(5-6):235-243. doi: 10.1159/000501384. Epub 2019 Jul 29.