PMID- 31357488
OWN - NLM
STAT- MEDLINE
DCOM- 20200109
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 15
DP  - 2019 Jul 26
TI  - Rapid or Slow Time to Brain Death? Impact on Kidney Graft Injuries in an 
      Allotransplantation Porcine Model.
LID - 10.3390/ijms20153671 [doi]
LID - 3671
AB  - The use of donors deceased after brain death (DBD) with extended criteria in 
      response to the shortage of grafts leads to the removal of more fragile kidneys. 
      These grafts are at greater risk of not being grafted or delayed function. A 
      better knowledge of the pathophysiology of DBDs would improve this situation. 
      There is a difference between the results from animal models of DBD and the 
      clinical data potentially explained by the kinetics of brain death induction. We 
      compared the effect of the induction rate of brain death on the recovery of 
      post-transplant renal function in a pig model of DBD followed by allografts in 
      nephrectomized pigs. Resumption of early function post-transplant was better in 
      the rapidly generated brain death group (RgBD) and graft fibrosis at three months 
      less important. Two groups had identical oxidative stress intensity but a greater 
      response to this oxidative stress by SIRT1, PGC1-alpha and NRF2 in the RgBD group. 
      Modulation of mechanistic target of rapamycin (mTOR) stimulation by NRF2 would 
      also regulate the survival/apoptosis balance of renal cells. For the first time 
      we have shown that an allostatic response to oxidative stress can explain the 
      impact of the rapidity of brain death induction on the quality of kidney 
      transplants.
FAU - Kerforne, Thomas
AU  - Kerforne T
AD  - CHU Poitiers, Coordination des prelevements d'organe et de tissus, F-86000 
      Poitiers, France.
AD  - CHU Poitiers, Departement d'anesthesie-reanimation, F-86000 Poitiers, France.
AD  - INSERM U1082 (IRTOMIT), F-86000 Poitiers, France.
FAU - Giraud, Sebastien
AU  - Giraud S
AD  - INSERM U1082 (IRTOMIT), F-86000 Poitiers, France.
AD  - CHU Poitiers, Service de Biochimie, F-86000 Poitiers, France.
AD  - Faculte de Medecine et Pharmacie, Universite de Poitiers, F-86000 Poitiers, 
      France.
FAU - Danion, Jerome
AU  - Danion J
AD  - CHU de Poitiers, Service de Chirurgie viscerale, F-86000 Poitiers, France.
FAU - Thuillier, Raphael
AU  - Thuillier R
AD  - INSERM U1082 (IRTOMIT), F-86000 Poitiers, France.
AD  - CHU Poitiers, Service de Biochimie, F-86000 Poitiers, France.
AD  - Faculte de Medecine et Pharmacie, Universite de Poitiers, F-86000 Poitiers, 
      France.
FAU - Couturier, Pierre
AU  - Couturier P
AD  - INSERM U1082 (IRTOMIT), F-86000 Poitiers, France.
AD  - CHU Poitiers, Service de Biochimie, F-86000 Poitiers, France.
AD  - IBiSA 'plate-forme MOdelisation Preclinique - Innovations Chirurgicale et 
      Technologique (MOPICT)', Domaine Experimental du Magneraud, F-17700 Surgeres, 
      France.
FAU - Hebrard, William
AU  - Hebrard W
AD  - IBiSA 'plate-forme MOdelisation Preclinique - Innovations Chirurgicale et 
      Technologique (MOPICT)', Domaine Experimental du Magneraud, F-17700 Surgeres, 
      France.
AD  - INRA, Unite experimentale Genetique, experimentations et systemes innovants 
      (GENESI), Domaine Experimental du Magneraud, F-17700 Surgeres, France.
FAU - Mimoz, Olivier
AU  - Mimoz O
AD  - Faculte de Medecine et Pharmacie, Universite de Poitiers, F-86000 Poitiers, 
      France.
AD  - CHU Poitiers, Service d'accueil des urgences, SAMU-SMUR, F-86000 Poitiers, 
      France.
FAU - Hauet, Thierry
AU  - Hauet T
AUID- ORCID: 0000-0002-0117-071X
AD  - INSERM U1082 (IRTOMIT), F-86000 Poitiers, France. thierry.hauet@gmail.com.
AD  - CHU Poitiers, Service de Biochimie, F-86000 Poitiers, France. 
      thierry.hauet@gmail.com.
AD  - Faculte de Medecine et Pharmacie, Universite de Poitiers, F-86000 Poitiers, 
      France. thierry.hauet@gmail.com.
AD  - IBiSA 'plate-forme MOdelisation Preclinique - Innovations Chirurgicale et 
      Technologique (MOPICT)', Domaine Experimental du Magneraud, F-17700 Surgeres, 
      France. thierry.hauet@gmail.com.
LA  - eng
GR  - program ET3-686/Fondation de l'Avenir pour la Recherche Medicale Appliquee/
GR  - convention 15/RPC-R-017/Conseil Regional Poitou-Charentes/
PT  - Journal Article
DEP - 20190726
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Biomarkers
MH  - Brain Death/*metabolism
MH  - Delayed Graft Function
MH  - Endothelium, Vascular/metabolism
MH  - Fibrosis
MH  - Kidney/*metabolism/pathology
MH  - *Kidney Transplantation
MH  - Kidney Tubules/metabolism
MH  - Models, Animal
MH  - Oxidative Stress
MH  - Renal Insufficiency/etiology/metabolism/pathology
MH  - Swine
MH  - Time Factors
MH  - Tissue Donors
MH  - Transplantation, Homologous
PMC - PMC6696377
OTO - NOTNLM
OT  - allostasis
OT  - brain death
OT  - kidney
OT  - mechanistic target of rapamycin
OT  - nuclear factor erythroid-2-related factor 2
OT  - oxidative stress
OT  - transplantation
COIS- The authors declare no conflict of interest.
EDAT- 2019/07/31 06:00
MHDA- 2020/01/10 06:00
PMCR- 2019/08/01
CRDT- 2019/07/31 06:00
PHST- 2019/07/05 00:00 [received]
PHST- 2019/07/18 00:00 [revised]
PHST- 2019/07/24 00:00 [accepted]
PHST- 2019/07/31 06:00 [entrez]
PHST- 2019/07/31 06:00 [pubmed]
PHST- 2020/01/10 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - ijms20153671 [pii]
AID - ijms-20-03671 [pii]
AID - 10.3390/ijms20153671 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Jul 26;20(15):3671. doi: 10.3390/ijms20153671.