PMID- 31358150
OWN - NLM
STAT- MEDLINE
DCOM- 20200923
LR  - 20200923
IS  - 1715-3360 (Electronic)
IS  - 0008-4182 (Linking)
VI  - 54
IP  - 4
DP  - 2019 Aug
TI  - Optical coherence tomography angiography features of optic nerve head drusen and 
      nonarteritic anterior ischemic optic neuropathy.
PG  - 495-500
LID - S0008-4182(18)30481-2 [pii]
LID - 10.1016/j.jcjo.2018.08.002 [doi]
AB  - OBJECTIVE: To evaluate the optic disc microvasculature in optic nerve head drusen 
      (ONHD) vasculature in comparison to acute nonarteritic anterior ischemic optic 
      neuropathy (NAION) and normal eyes using optical coherence tomography angiography 
      (OCT-A). METHODS: Ten eyes with ONHD, 10 eyes with acute NAION, and 10 healthy 
      eyes were included in this prospective, comparative, observational case series. 
      OCT-A imaging was performed on the optic discs. Qualitative grading was performed 
      for dilation and tortuosity of the peripapillary vessels by 3 graders. 
      Quantitative comparison was performed for peripapillary and inside disc vessel 
      densities in nerve head (NH) and retinal peripapillary capillary (RPC) slabs. 
      RESULTS: The intergrader agreement for dilation and tortuosity of the 
      peripapillary vessels was poor (0.313 and 0.182 for vascular dilation in nerve 
      head and radial peripapillary capillary enface images, respectively, and 0.478 
      and 0.490 for vascular tortuosity in nerve head and radial peripapillary 
      capillary enface images, respectively). In NH en face images, the vessel density 
      measurements were statistically significantly different between the 3 groups (all 
      p < 0.05). In RPC en face images, the vessel density measurements were 
      statistically significantly different between the 3 groups (all p < 0.05) except 
      for nasal peripapillary sector (0.08). CONCLUSION: Despite poor intergrader 
      agreement in qualitative analysis, quantitative OCT-A evaluation may 
      differentiate optic disc edema due to NAION from pseudodisc edema due to ONHD.
CI  - Copyright (c) 2018 Canadian Ophthalmological Society. Published by Elsevier Inc. 
      All rights reserved.
FAU - Abri Aghdam, Kaveh
AU  - Abri Aghdam K
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.. Electronic address: Kaveh.abri@gmail.com.
FAU - Ashraf Khorasani, Maryam
AU  - Ashraf Khorasani M
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Soltan Sanjari, Mostafa
AU  - Soltan Sanjari M
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Habibi, Abbas
AU  - Habibi A
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Shenazandi, Hamideh
AU  - Shenazandi H
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Kazemi, Pegah
AU  - Kazemi P
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
FAU - Ghasemi Falavarjani, Khalil
AU  - Ghasemi Falavarjani K
AD  - Eye Research Center, Rassoul Akram Hospital, Iran University of Medical Sciences, 
      Tehran, Iran.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
DEP - 20181017
PL  - England
TA  - Can J Ophthalmol
JT  - Canadian journal of ophthalmology. Journal canadien d'ophtalmologie
JID - 0045312
SB  - IM
MH  - Adult
MH  - Female
MH  - Fluorescein Angiography/*methods
MH  - Follow-Up Studies
MH  - Fundus Oculi
MH  - Humans
MH  - Male
MH  - Microvessels/pathology
MH  - Nerve Fibers/pathology
MH  - Optic Disk/*pathology
MH  - Optic Disk Drusen/*diagnosis
MH  - Optic Neuropathy, Ischemic/*diagnosis
MH  - Prospective Studies
MH  - Retinal Ganglion Cells/*pathology
MH  - Tomography, Optical Coherence/*methods
MH  - *Visual Acuity
MH  - Visual Fields
EDAT- 2019/07/31 06:00
MHDA- 2020/09/24 06:00
CRDT- 2019/07/31 06:00
PHST- 2018/05/02 00:00 [received]
PHST- 2018/07/29 00:00 [revised]
PHST- 2018/08/02 00:00 [accepted]
PHST- 2019/07/31 06:00 [entrez]
PHST- 2019/07/31 06:00 [pubmed]
PHST- 2020/09/24 06:00 [medline]
AID - S0008-4182(18)30481-2 [pii]
AID - 10.1016/j.jcjo.2018.08.002 [doi]
PST - ppublish
SO  - Can J Ophthalmol. 2019 Aug;54(4):495-500. doi: 10.1016/j.jcjo.2018.08.002. Epub 
      2018 Oct 17.