PMID- 31361378
OWN - NLM
STAT- MEDLINE
DCOM- 20200706
LR  - 20200706
IS  - 1573-3599 (Electronic)
IS  - 1059-7700 (Linking)
VI  - 28
IP  - 5
DP  - 2019 Oct
TI  - Establishing the minimum clinically important difference for the Genetic 
      Counseling Outcome Scale (GCOS-24).
PG  - 1003-1010
LID - 10.1002/jgc4.1152 [doi]
AB  - To establish the smallest change in genetic counseling outcome that is meaningful 
      for patients, the aim of this study was to establish the Minimum Clinically 
      Important Difference (MCID) for the Genetic Counseling Outcome Scale (GCOS-24). 
      GCOS-24 is a patient-reported outcome measure for clinical genetics services. 
      Secondary aims included understanding what patients deem important for reaching 
      this score. Participants were 74 new patients recruited from the All Wales 
      Medical Genetics Service, between April 2016 and December 2016. An anchor-based, 
      global transition question methodology was used to identify the MCID, by asking 
      participants how much meaningful change they experienced following their genetics 
      appointment, and comparing this with GCOS-24 change scores. This ensured that the 
      established score was clinically meaningful to patients. Comments from a free 
      text response box were analyzed using qualitative thematic analysis. The mean 
      score of the group who felt "a little better" was determined to be the MCID. The 
      MCID was established to be a GCOS-24 score increase of 10.3 points after a 
      clinical genetics appointment. This score was significantly different from the 
      group "neutral" (0.64 points), using an independent samples t test. Themes 
      identified as important for reaching the MCID included "future and family". These 
      findings contribute to interpretability of GCOS-24 and provide some useful 
      insights for genetic counseling service development.
CI  - (c) 2019 National Society of Genetic Counselors.
FAU - Thomas, Charlene
AU  - Thomas C
AD  - Centre for Medical Education, School of Medicine, Cardiff University, Cardiff, 
      UK.
FAU - McAllister, Marion
AU  - McAllister M
AD  - Centre for Medical Education, School of Medicine, Cardiff University, Cardiff, 
      UK.
LA  - eng
PT  - Journal Article
DEP - 20190730
PL  - United States
TA  - J Genet Couns
JT  - Journal of genetic counseling
JID - 9206865
SB  - IM
MH  - Female
MH  - Genetic Counseling/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Patient Reported Outcome Measures
MH  - Wales
OTO - NOTNLM
OT  - Genetic Counseling Outcome Scale
OT  - clinical genetics
OT  - genetic counseling
OT  - genetics
OT  - minimum clinically important difference
OT  - patient-reported outcome measure
EDAT- 2019/07/31 06:00
MHDA- 2020/07/07 06:00
CRDT- 2019/07/31 06:00
PHST- 2019/10/14 00:00 [received]
PHST- 2019/06/22 00:00 [revised]
PHST- 2019/06/24 00:00 [accepted]
PHST- 2019/07/31 06:00 [pubmed]
PHST- 2020/07/07 06:00 [medline]
PHST- 2019/07/31 06:00 [entrez]
AID - 10.1002/jgc4.1152 [doi]
PST - ppublish
SO  - J Genet Couns. 2019 Oct;28(5):1003-1010. doi: 10.1002/jgc4.1152. Epub 2019 Jul 
      30.