PMID- 31366525
OWN - NLM
STAT- MEDLINE
DCOM- 20190807
LR  - 20190807
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 39
IP  - 8
DP  - 2019 Aug
TI  - Unusual Karyotype in Acute Myelomonocitic Leukemia: A Case Report.
PG  - 4329-4332
LID - 10.21873/anticanres.13599 [doi]
AB  - BACKGROUND/AIM: Acute myeloid leukemia is well characterized by chromosomal 
      aberrations that correspond to various subtypes of acute leukemias. The 
      t(8;21)(q22;q22) is a frequent chromosomal abnormality strongly associated with 
      acute myeloblastic leukemia with maturation (AML-M2), but is rarely associated 
      with other subtypes. Translocation involving a third chromosome could produce new 
      genetic rearrangements that lead to leukemogenesis. PATIENTS AND METHODS: 
      Conventional cytogenetic analysis and fluorescence in situ hybridization (FISH) 
      were performed to identify the karyotype. Reverse transcriptase polymerase chain 
      reaction (RT-PCR) was used to detect the AML1/ETO transcript. RESULTS/CONCLUSION: 
      We herein report a novel rearrangement with a three-way translocation involving 
      chromosomes 8, 21 and another unknown chromosome, in an 83-year-old female 
      patient diagnosed as AML-M4, with an ALM1/ETO negative transcript. This is an 
      uncommon case of AML-M4 with three-way translocation in a new variant of t(8;21) 
      acute myeloid leukaemia. The detailed mechanism of different phenotype expression 
      is unclear. Further study is needed to identify the leukemogenetic transformation 
      resulting from t(8;21) translocation.
CI  - Copyright(c) 2019, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Consoli, Maria Letizia
AU  - Consoli ML
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy marzia.consoli@libero.it.
FAU - Romano, Alessandra
AU  - Romano A
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy.
FAU - Parrinello, Nunziatina Laura
AU  - Parrinello NL
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy.
FAU - Tambe, Loredana
AU  - Tambe L
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy.
FAU - Romeo, Maria Anna
AU  - Romeo MA
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy.
FAU - Salemi, Domenico
AU  - Salemi D
AD  - Division of Hematology and Bone Marrow Transplant, A.O. Ospedali Riuniti Villa 
      Sofia-Cervello, Palermo, Italy.
FAU - Santoro, Alessandra
AU  - Santoro A
AD  - Division of Hematology and Bone Marrow Transplant, A.O. Ospedali Riuniti Villa 
      Sofia-Cervello, Palermo, Italy.
FAU - DI Raimondo, Francesco
AU  - DI Raimondo F
AD  - Division of Hematology and Bone Marrow Transplant, A.O.U. Policlinico Vittorio 
      Emanuele, Catania, Italy.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Aged, 80 and over
MH  - Chromosomes, Human, Pair 21/genetics
MH  - Chromosomes, Human, Pair 8/genetics
MH  - *Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/methods
MH  - *Karyotype
MH  - Karyotyping/methods
MH  - Leukemia, Myelomonocytic, Acute/diagnosis/*genetics/pathology
MH  - Translocation, Genetic/*genetics
OTO - NOTNLM
OT  - AML
OT  - three-way translocation
OT  - variant t(8;21)
EDAT- 2019/08/02 06:00
MHDA- 2019/08/08 06:00
CRDT- 2019/08/02 06:00
PHST- 2019/06/25 00:00 [received]
PHST- 2019/07/02 00:00 [revised]
PHST- 2019/07/04 00:00 [accepted]
PHST- 2019/08/02 06:00 [entrez]
PHST- 2019/08/02 06:00 [pubmed]
PHST- 2019/08/08 06:00 [medline]
AID - 39/8/4329 [pii]
AID - 10.21873/anticanres.13599 [doi]
PST - ppublish
SO  - Anticancer Res. 2019 Aug;39(8):4329-4332. doi: 10.21873/anticanres.13599.