PMID- 31368266
OWN - NLM
STAT- MEDLINE
DCOM- 20190807
LR  - 20190807
IS  - 1000-0607 (Print)
IS  - 1000-0607 (Linking)
VI  - 44
IP  - 6
DP  - 2019 Jun 25
TI  - [Acupoint application of herbal paste relieves symptoms and naso-mucosal 
      inflammatory response by down-regulating serum TGF-beta1 in allergic rhinitis rats].
PG  - 430-3
LID - 10.13702/j.1000-0607.180369 [doi]
AB  - OBJECTIVE: To observe the effect of acupoint application of herbal paste on 
      symptoms of allergic rhinitis (AR), serum immunoglobulin E (IgE) and transforming 
      growth factor beta 1 (TGF-beta1) level, and number of nasal eosinophils (EOS) in 
      rats with AR, so as to explore its underlying mechanisms. METHODS: Forty male 
      Wistar rats were randomly divided into normal control, model, medication and 
      acupoint application groups (n＝10 rats per group). The AR model was established 
      by intraperitoneal (i.p.) injection of mixture solution of ovalbumin, aluminum 
      hydroxide and normal saline (once every other day, for 7 times), and nasal drip 
      plus spray inhalation of ovalbumin (on the following day of i．p., once daily for 
      9 days). For acupoint application, the prepared herbal paste (containing White 
      Mustard Seed, Rhizoma Corydalis, unprocessed Radix Kansui, Herba Asari and ginger 
      juice) was applied to bilateral "Feishu" (BL13), "Pishu" (BL20) and "Shenshu" 
      (BL23) for 2 h, once every other day for 7 times. The rats in the medication 
      group were given Fluticasone Propionate nasal spray daily for 14 days. Scores of 
      nasal itching, sneezing and nasal discharge on the day after modeling and the 
      ending of the intervention were used to evaluate behavioral changes. Enzyme 
      linked immunosorbent assay (ELISA) was used to detect the levels of serum IgE and 
      TGF-beta1, and the infiltration state of EOS in the nasal mucosa tissue was observed 
      under light microscope after HE staining. RESULTS: After modeling and compared 
      with the normal control group, the behavioral scores and the levels of serum IgE 
      and TGF-beta1 were significantly higher (P<0.05), and the infiltration state of EOS 
      got worse. Compared with the model group, the increased behavioral score and 
      serum IgE and TGF-beta1 levels were evidently suppressed (P<0.05) and EOS 
      infiltration severity in the nasal mucosa was obviously milder in both medication 
      and acupoint application groups. No significant differences were found between 
      the medication and acupoint application groups in behavioral score and serum IgE 
      and TGF-beta1 levels (P>0.05). CONCLUSION: Acupoint application can improve the 
      symptoms of AR rats, which may be associated with its effect in down-regulating 
      the levels of serum IgE and TGF-beta1.
FAU - Chen, Shan
AU  - Chen S
AD  - Department of Acupuncture and Moxibustion, The First Affiliated Hospital of 
      Zhejiang University of Chinese Medicine, Hangzhou 310006, China; The First School 
      of Clinical Medicine of Zhejiang University of Chinese Medicine, Hangzhou 310053.
FAU - Jin, Yu-Tong
AU  - Jin YT
AD  - The First School of Clinical Medicine of Zhejiang University of Chinese Medicine, 
      Hangzhou 310053.
FAU - Zhu, Zheng-Yang
AU  - Zhu ZY
AD  - The First School of Clinical Medicine of Zhejiang University of Chinese Medicine, 
      Hangzhou 310053.
FAU - Wu, Ling-Tao
AU  - Wu LT
AD  - The First School of Clinical Medicine of Zhejiang University of Chinese Medicine, 
      Hangzhou 310053.
FAU - Xuan, Li-Hua
AU  - Xuan LH
AD  - Department of Acupuncture and Moxibustion, The First Affiliated Hospital of 
      Zhejiang University of Chinese Medicine, Hangzhou 310006, China; The First School 
      of Clinical Medicine of Zhejiang University of Chinese Medicine, Hangzhou 310053.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhen Ci Yan Jiu
JT  - Zhen ci yan jiu = Acupuncture research
JID - 8507710
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - *Acupuncture Points
MH  - Animals
MH  - Male
MH  - Nasal Mucosa
MH  - Rats
MH  - Rats, Wistar
MH  - *Rhinitis, Allergic
MH  - Transforming Growth Factor beta1
OTO - NOTNLM
OT  - Acupoint application
OT  - Allergic rhinitis
OT  - Inflammatory regulation
OT  - TGF-beta1
EDAT- 2019/08/02 06:00
MHDA- 2019/08/08 06:00
CRDT- 2019/08/02 06:00
PHST- 2019/08/02 06:00 [entrez]
PHST- 2019/08/02 06:00 [pubmed]
PHST- 2019/08/08 06:00 [medline]
AID - 10.13702/j.1000-0607.180369 [doi]
PST - ppublish
SO  - Zhen Ci Yan Jiu. 2019 Jun 25;44(6):430-3. doi: 10.13702/j.1000-0607.180369.