PMID- 3136905
OWN - NLM
STAT- MEDLINE
DCOM- 19880927
LR  - 20190516
IS  - 0706-7437 (Print)
IS  - 0706-7437 (Linking)
VI  - 33
IP  - 5
DP  - 1988 Jun
TI  - Biological markers in borderline personality disorders: an overview.
PG  - 350-4
AB  - The state of knowledge in the area of suggested biological markers that may 
      delineate subpopulations of patients with borderline personality disorders (BPD) 
      is reviewed. There is widespread disagreement as to the specificity of these 
      markers. The clinical implications of Axis I--Axis II, state vs. trait, acute vs. 
      chronic, and definite vs. probable diagnoses, all seem to contribute to the 
      confusion in this area. Some patients with BPD and with schizotypal personality 
      disorders (SPD) share neuroendocrine abnormalities with affective disorders (AD) 
      and schizophrenic (SCH) patients respectively. This interface and/or potential 
      overlap between personality disorders (PD) and the major mental disorders is 
      discussed with special reference to the DST, TRH/TSH test, and REM latency which 
      have already been established as valuable biological markers for certain subtypes 
      of depression. In contrast, biologic abnormalities observed in chronic 
      schizophrenia are also present in some SPD patients. Current data are supportive 
      of the hypothesis that some PD patients are independent whereas others are 
      genetically related to the major mental disorders.
FAU - Steiner, M
AU  - Steiner M
AD  - Faculty of Health Sciences, McMaster University, Hamilton, Ontario.
FAU - Links, P S
AU  - Links PS
FAU - Korzekwa, M
AU  - Korzekwa M
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Can J Psychiatry
JT  - Canadian journal of psychiatry. Revue canadienne de psychiatrie
JID - 7904187
RN  - 5Y5F15120W (Thyrotropin-Releasing Hormone)
RN  - 7S5I7G3JQL (Dexamethasone)
RN  - 9002-71-5 (Thyrotropin)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Borderline Personality Disorder/*diagnosis
MH  - *Dexamethasone
MH  - *Electroencephalography
MH  - Humans
MH  - Hydrocortisone/blood
MH  - Personality Disorders/*diagnosis
MH  - Sleep Stages/physiology
MH  - Thyrotropin/blood
MH  - *Thyrotropin-Releasing Hormone
RF  - 39
EDAT- 1988/06/01 00:00
MHDA- 1988/06/01 00:01
CRDT- 1988/06/01 00:00
PHST- 1988/06/01 00:00 [pubmed]
PHST- 1988/06/01 00:01 [medline]
PHST- 1988/06/01 00:00 [entrez]
AID - 10.1177/070674378803300507 [doi]
PST - ppublish
SO  - Can J Psychiatry. 1988 Jun;33(5):350-4. doi: 10.1177/070674378803300507.