PMID- 31369207
OWN - NLM
STAT- MEDLINE
DCOM- 20200527
LR  - 20200527
IS  - 2042-6984 (Electronic)
IS  - 2042-6976 (Linking)
VI  - 9
IP  - 9
DP  - 2019 Sep
TI  - Serum levels of stress hormones in Albanian patients with allergic rhinitis.
PG  - 1077-1082
LID - 10.1002/alr.22370 [doi]
AB  - BACKGROUND: The integration of the immune and endocrine systems through a network 
      of signaling molecules-including cytokines and hormones-produces a consequent 
      modulatory effect on immune function. In this study we aimed to comparatively 
      evaluate the serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 
      cortisol in patients with allergic rhinitis and healthy control subjects. 
      METHODS: Morning fasting blood samples were obtained from 96 participants, 
      including 66 patients with allergic rhinitis (mean age, 28 +/- 10.7 years; range, 
      11-59 years) and 30 healthy control subjects (mean age, 32.4 +/- 11.1 years; range, 
      14-57 years). Total immunoglobulin E (IgE), DHEA-S, and cortisol concentrations 
      were measured by radioimmunoassay. RESULTS: Female patients with allergic 
      rhinitis exhibited lower DHEA-S levels than male patients and control subjects (p 
      < 0.001). Although no intergroup differences were observed in the morning:evening 
      cortisol ratio, the DHEA-S:cortisol ratio was the highest among female patients 
      with allergic rhinitis (1:11). Total IgE levels were significantly higher among 
      patients of both sexes (p < 0.05) than among the control subjects. There was a 
      positive correlation between body mass index and age among all groups of 
      participants (male and female patients: r = 0.6 and 0.7, respectively; male and 
      female controls: r = 0.6 and 0.4, respectively) and a negative correlation 
      between DHEA-S level and age among females (patients and controls: r = -0.4 and 
      -0.5, respectively) and healthy male subjects (r = -0.7). CONCLUSION: In this 
      study, female patients with allergic rhinitis exhibited significantly lower 
      DHEA-S levels than their healthy counterparts and male patients. These results 
      should be confirmed in a larger group of participants.
CI  - (c) 2019 ARS-AAOA, LLC.
FAU - Lokaj-Berisha, Violeta
AU  - Lokaj-Berisha V
AD  - Department of Physiology & Immunology, Faculty of Medicine, University of 
      Prishtina, Republic of Kosova.
FAU - Gacaferri-Lumezi, Besa
AU  - Gacaferri-Lumezi B
AD  - Department of Physiology & Immunology, Faculty of Medicine, University of 
      Prishtina, Republic of Kosova.
FAU - Berisha, Naser
AU  - Berisha N
AD  - Department of Obstetrics and Gynecology, University Clinical Centre, Prishtina, 
      Republic of Kosova.
LA  - eng
PT  - Journal Article
DEP - 20190801
PL  - United States
TA  - Int Forum Allergy Rhinol
JT  - International forum of allergy & rhinology
JID - 101550261
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 57B09Q7FJR (Dehydroepiandrosterone Sulfate)
RN  - WI4X0X7BPJ (Hydrocortisone)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Albania/epidemiology
MH  - Child
MH  - Dehydroepiandrosterone Sulfate/*blood
MH  - Down-Regulation
MH  - Female
MH  - Humans
MH  - Hydrocortisone/*blood
MH  - Immunoglobulin E/blood
MH  - Male
MH  - Middle Aged
MH  - Radioimmunoassay
MH  - Rhinitis, Allergic/*diagnosis/epidemiology
MH  - *Sex Factors
MH  - Young Adult
OTO - NOTNLM
OT  - age
OT  - allergies
OT  - body mass index
OT  - cortisol
OT  - dehydroepiandrosterone sulfate
OT  - radioimmunoassay
OT  - rhinitis
OT  - sex
OT  - total immunoglobulin E
EDAT- 2019/08/02 06:00
MHDA- 2020/05/28 06:00
CRDT- 2019/08/02 06:00
PHST- 2019/02/15 00:00 [received]
PHST- 2019/05/22 00:00 [revised]
PHST- 2019/05/30 00:00 [accepted]
PHST- 2019/08/02 06:00 [pubmed]
PHST- 2020/05/28 06:00 [medline]
PHST- 2019/08/02 06:00 [entrez]
AID - 10.1002/alr.22370 [doi]
PST - ppublish
SO  - Int Forum Allergy Rhinol. 2019 Sep;9(9):1077-1082. doi: 10.1002/alr.22370. Epub 
      2019 Aug 1.