PMID- 31369712
OWN - NLM
STAT- MEDLINE
DCOM- 20201117
LR  - 20201117
IS  - 1205-7541 (Electronic)
IS  - 0008-4212 (Linking)
VI  - 98
IP  - 2
DP  - 2020 Feb
TI  - Genes and genetics in hyperhomocysteinemia and the "1-carbon metabolism": 
      implications for retinal structure and eye functions.
PG  - 51-60
LID - 10.1139/cjpp-2019-0236 [doi]
AB  - Homocysteine (Hcy), a sulfur-containing nonproteinogenic amino acid, is generated 
      as a metabolic intermediate. Hcy constitutes an important part of the "1-carbon 
      metabolism" during methionine turnover. Elevated levels of Hcy known as 
      hyperhomocysteinemia (HHcy) results from vitamin B deficiency, lack of exercise, 
      smoking, excessive alcohol intake, high-fat and methionine-rich diet, and the 
      underlying genetic defects. These factors directly affect the "1-carbon 
      metabolism (methionine-Hcy-folate)" of a given cell. In fact, the Hcy levels are 
      determined primarily by dietary intake, vitamin status, and the genetic blueprint 
      of the susceptible individual. Although Hcy performs an important role in 
      cellular functions, genetic alterations in any of the key enzymes responsible for 
      the "1-carbon metabolism" could potentially upset the metabolic cycle, thus 
      causing HHcy environment in susceptible people. As such, HHcy relates to several 
      clinical conditions like atherosclerosis, myocardial infarction, stroke, 
      cognitive impairment, dementia, Parkinson's disease, multiple sclerosis, 
      epilepsy, and ocular disorders, among others. This article summarizes the 
      findings from our laboratory and public database regarding genetics of HHcy and 
      its effects on ocular disorders, their respective management during dysregulation 
      of the 1-carbon metabolism.
FAU - George, Akash K
AU  - George AK
AD  - Eye and Vision Science Laboratory, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
FAU - Majumder, Avisek
AU  - Majumder A
AD  - Department of Medicine, UCSF Helen Diller Family Comprehensive Cancer Center, 
      University of California San Francisco, San Francisco, California 94158, USA.
FAU - Ice, Hayley
AU  - Ice H
AD  - Eye and Vision Science Laboratory, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
FAU - Homme, Rubens P
AU  - Homme RP
AD  - Eye and Vision Science Laboratory, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
FAU - Eyob, Wintana
AU  - Eyob W
AD  - College of Arts and Sciences, Case Western Reserve University, 10900 Euclid Ave, 
      Cleveland, OH 44106, USA.
FAU - Tyagi, Suresh C
AU  - Tyagi SC
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
FAU - Singh, Mahavir
AU  - Singh M
AD  - Eye and Vision Science Laboratory, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
AD  - Department of Physiology, University of Louisville School of Medicine, 
      Louisville, Kentucky 40202, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190801
PL  - Canada
TA  - Can J Physiol Pharmacol
JT  - Canadian journal of physiology and pharmacology
JID - 0372712
RN  - 7440-44-0 (Carbon)
SB  - IM
MH  - Animals
MH  - Carbon/*metabolism
MH  - Humans
MH  - Hyperhomocysteinemia/*genetics/*metabolism/pathology/physiopathology
MH  - Retina/*pathology/*physiopathology
OTO - NOTNLM
OT  - genetic polymorphism
OT  - hyperhomocysteinemic eye
OT  - oxidative stress
OT  - perte de la vision
OT  - polymorphisme genetique
OT  - stress oxydatif
OT  - vasculopathie
OT  - vasculopathy
OT  - vision loss
OT  - oeil hyperhomocysteinemique
EDAT- 2019/08/02 06:00
MHDA- 2020/11/18 06:00
CRDT- 2019/08/02 06:00
PHST- 2019/08/02 06:00 [pubmed]
PHST- 2020/11/18 06:00 [medline]
PHST- 2019/08/02 06:00 [entrez]
AID - 10.1139/cjpp-2019-0236 [doi]
PST - ppublish
SO  - Can J Physiol Pharmacol. 2020 Feb;98(2):51-60. doi: 10.1139/cjpp-2019-0236. Epub 
      2019 Aug 1.