PMID- 31370161
OWN - NLM
STAT- MEDLINE
DCOM- 20191231
LR  - 20200225
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 20
IP  - 15
DP  - 2019 Jul 31
TI  - Effects of Aging on Hair Color, Melanosome Morphology, and Melanin Composition in 
      Japanese Females.
LID - 10.3390/ijms20153739 [doi]
LID - 3739
AB  - In a previous study, we showed that the size of melanosomes isolated from 
      Japanese female hairs enlarges with age, and this affects the hair color. In this 
      study, we analyzed the age-dependent changes in hair melanin in order to further 
      explore the factors related to hair color changing by aging. A significant 
      positive correlation with age was found in the total melanin amount (TM) and the 
      mol% of 5,6-dihydroxyindole (DHI) units, while no correlation was found in 
      pheomelanin mol%. TM showed significant correlations with hair color parameters 
      and the melanosome volume, suggesting that hair color darkening by aging is 
      caused by the increase in TM due to the enlargement of the size of melanosome. 
      From the measurement of absorbance spectra on synthetic eumelanins with different 
      ratios of DHI and 5,6-dihydroxyindole-2-carboxylic acid (DHICA), we found that 
      the increase in DHI mol% also contributes to the darkening of hair color by 
      aging. In addition, the level of pyrrole-2,3-dicarboxylic acid (PDCA), a marker 
      of DHI melanin, showed a significant negative correlation with the aspect ratio 
      of melanosome, suggesting a contribution of DHI melanin to the change in 
      melanosome morphology by aging.
FAU - Itou, Takashi
AU  - Itou T
AUID- ORCID: 0000-0002-7431-8818
AD  - Kao Corporation, R&D - Hair Care Products Research, Tokyo 131-8501, Japan. 
      itou.takashi1@kao.com.
FAU - Ito, Shosuke
AU  - Ito S
AUID- ORCID: 0000-0001-9182-5144
AD  - Department of Chemistry, Fujita Health University School of Medical Sciences, 
      Toyoake, Aichi 470-1192, Japan.
FAU - Wakamatsu, Kazumasa
AU  - Wakamatsu K
AUID- ORCID: 0000-0003-1748-9001
AD  - Department of Chemistry, Fujita Health University School of Medical Sciences, 
      Toyoake, Aichi 470-1192, Japan.
LA  - eng
PT  - Journal Article
DEP - 20190731
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (Indoles)
RN  - 0 (Melanins)
RN  - 0 (Pyrroles)
RN  - 0 (pheomelanin)
RN  - 1125-32-2 (pyrrole-2,3-dicarboxylic acid)
RN  - 12627-86-0 (eumelanin)
RN  - 4790-08-3 (5,6-dihydroxy-2-indolylcarboxylic acid)
RN  - Z3OC8499KG (5,6-dihydroxyindole)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aging/*physiology
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Hair/chemistry/*metabolism/ultrastructure
MH  - Hair Color/*physiology
MH  - Humans
MH  - Indoles/metabolism
MH  - Melanins/*metabolism
MH  - Melanosomes/chemistry/metabolism/*ultrastructure
MH  - Middle Aged
MH  - Organelle Size
MH  - Pyrroles/metabolism
PMC - PMC6696507
OTO - NOTNLM
OT  - 5,6-dihydroxyindole
OT  - 5,6-dihydroxyindole-2-carboxylic acid
OT  - aging
OT  - hair
OT  - melanin
OT  - melanosome
OT  - morphology
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/03 06:00
MHDA- 2020/01/01 06:00
PMCR- 2019/08/01
CRDT- 2019/08/03 06:00
PHST- 2019/06/26 00:00 [received]
PHST- 2019/07/25 00:00 [revised]
PHST- 2019/07/27 00:00 [accepted]
PHST- 2019/08/03 06:00 [entrez]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2020/01/01 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - ijms20153739 [pii]
AID - ijms-20-03739 [pii]
AID - 10.3390/ijms20153739 [doi]
PST - epublish
SO  - Int J Mol Sci. 2019 Jul 31;20(15):3739. doi: 10.3390/ijms20153739.