PMID- 31371431
OWN - NLM
STAT- MEDLINE
DCOM- 20200629
LR  - 20221207
IS  - 1935-5548 (Electronic)
IS  - 0149-5992 (Linking)
VI  - 42
IP  - 10
DP  - 2019 Oct
TI  - Inflammatory Cytokines Associated With Failure of Lower-Extremity Endovascular 
      Revascularization (LER): A Prospective Study of a Population With Diabetes.
PG  - 1939-1945
LID - 10.2337/dc19-0408 [doi]
AB  - OBJECTIVE: Peripheral artery disease (PAD) is one of the most relevant 
      complications of diabetes. Although several pharmacological and revascularization 
      approaches are available for treating patients with diabetes and PAD, an 
      endovascular approach is often associated with postprocedural complications that 
      can increase the risk for acute limb ischemia or amputation. However, no 
      definitive molecular associations have been described that could explain the 
      difference in outcomes after endovascular treatment in patients with diabetes, 
      PAD, and chronic limb-threatening ischemia (CLTI). RESEARCH DESIGN AND METHODS: 
      We evaluated the relationship between the levels of the main cytokines associated 
      with diabetic atherosclerosis and the outcomes after endovascular procedures in 
      patients with diabetes, PAD, and CLTI. RESULTS: A total of 299 patients with 
      below-the-knee occlusive disease who were undergoing an angioplasty procedure 
      were enrolled. The levels of key cytokines-osteoprotegerin (OPG), tumor necrosis 
      factor-alpha (TNF-alpha), interleukin-6 (IL-6), and C-reactive protein (CRP)-were 
      measured, and major adverse limb events (MALE) and major adverse cardiovascular 
      events (MACE) were assessed 1, 3, 6, and 12 months after the procedure. There was 
      a linear trend from the lowest to the highest quartile for each cytokine at 
      baseline and incident MALE. A linear association was also observed between 
      increasing levels of each cytokine and incident MACE. Receiver operating 
      characteristics models were constructed using clinical and laboratory risk 
      factors, and the inclusion of cytokines significantly improved the prediction of 
      incident events. CONCLUSIONS: We demonstrated that elevated OPG, TNF-alpha, IL-6, and 
      CRP levels at baseline correlate with worse vascular outcomes in patients with 
      diabetes, PAD, and CLTI undergoing an endovascular procedure.
CI  - (c) 2019 by the American Diabetes Association.
FAU - Biscetti, Federico
AU  - Biscetti F
AUID- ORCID: 0000-0001-7449-657X
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy 
      f.biscetti@gmail.com.
AD  - UOC Clinica Medica e Malattie Vascolari, Rome, Italy.
AD  - Laboratorio di Biologia e Genetica Vascolare, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
FAU - Ferraro, Pietro Manuel
AU  - Ferraro PM
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
AD  - UOC Nefrologia, Rome, Italy.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Hiatt, William R
AU  - Hiatt WR
AD  - Division of Cardiology, Department of Medicine, University of Colorado School of 
      Medicine, and CPC Clinical Research, Aurora, CO.
FAU - Angelini, Flavia
AU  - Angelini F
AD  - Laboratorio di Biologia e Genetica Vascolare, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
FAU - Nardella, Elisabetta
AU  - Nardella E
AD  - Laboratorio di Biologia e Genetica Vascolare, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
FAU - Cecchini, Andrea Leonardo
AU  - Cecchini AL
AD  - Laboratorio di Biologia e Genetica Vascolare, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
FAU - Santoliquido, Angelo
AU  - Santoliquido A
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
AD  - UOS Angiologia CIC, Rome, Italy.
FAU - Pitocco, Dario
AU  - Pitocco D
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
AD  - UOSA Diabetologia, Rome, Italy.
FAU - Landolfi, Raffaele
AU  - Landolfi R
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
AD  - UOC Clinica Medica e Malattie Vascolari, Rome, Italy.
AD  - Universita Cattolica del Sacro Cuore, Rome, Italy.
FAU - Flex, Andrea
AU  - Flex A
AD  - Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
AD  - Laboratorio di Biologia e Genetica Vascolare, Universita Cattolica del Sacro 
      Cuore, Rome, Italy.
AD  - UOSA Medicina delle Malattie Vascolari Periferiche, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190801
PL  - United States
TA  - Diabetes Care
JT  - Diabetes care
JID - 7805975
RN  - 0 (Cytokines)
RN  - 0 (Inflammation Mediators)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Amputation, Surgical/statistics & numerical data
MH  - Atherosclerosis/etiology/physiopathology/surgery
MH  - Cytokines/*blood
MH  - *Diabetes Mellitus/blood/epidemiology/physiopathology/surgery
MH  - Diabetic Angiopathies/physiopathology/*surgery
MH  - *Endovascular Procedures/adverse effects/statistics & numerical data
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Incidence
MH  - Inflammation Mediators/*blood
MH  - Ischemia/blood/epidemiology/surgery
MH  - Limb Salvage/adverse effects/methods
MH  - Lower Extremity/blood supply/*surgery
MH  - Male
MH  - Middle Aged
MH  - Peripheral Arterial Disease/blood/epidemiology/physiopathology/*surgery
MH  - Prospective Studies
MH  - Risk Factors
MH  - Treatment Failure
MH  - Treatment Outcome
EDAT- 2019/08/03 06:00
MHDA- 2020/07/01 06:00
CRDT- 2019/08/03 06:00
PHST- 2019/02/26 00:00 [received]
PHST- 2019/07/11 00:00 [accepted]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2020/07/01 06:00 [medline]
PHST- 2019/08/03 06:00 [entrez]
AID - dc19-0408 [pii]
AID - 10.2337/dc19-0408 [doi]
PST - ppublish
SO  - Diabetes Care. 2019 Oct;42(10):1939-1945. doi: 10.2337/dc19-0408. Epub 2019 Aug 
      1.