PMID- 31371947
OWN - NLM
STAT- MEDLINE
DCOM- 20191011
LR  - 20231012
IS  - 1178-2013 (Electronic)
IS  - 1176-9114 (Print)
IS  - 1176-9114 (Linking)
VI  - 14
DP  - 2019
TI  - Chlorins e6 loaded silica nanoparticles coated with gastric cancer cell membrane 
      for tumor specific photodynamic therapy of gastric cancer.
PG  - 5061-5071
LID - 10.2147/IJN.S202910 [doi]
AB  - Background: Photodynamic therapy (PDT) is widely recognized as a promising way to 
      cure cancer. However, the limited tumor homing property of currently available 
      drug delivery systems (DDSs) is the bottleneck for the delivery of photodynamic 
      agents. Purpose: In our study, we decorated silica nanoparticles (SLN) with cell 
      membrane (CM) derived from SGC7901 cells to construct carrier (CM/SLN) which was 
      able to to specifically target the homogenous SGC7901 cells. Materials and 
      methods: Furthermore, the decent drug loading capability of CM/SLN was adopted to 
      load photodynamic agent chlorins e6 (Ce6) to finally construct aDDS suitable for 
      tumor-targeted PDT of gastric cancer. Results: The experimental results suggested 
      that CM/SLN/Ce6 was nano-sized particles with good dispersion and stability in 
      physiological conditions. Moreover, due to the modification of CM,CM/SLN/Ce6 
      could specifically target the homogenous SGC7901 cells both in vitro and in vivo. 
      Most importantly, further in vivo results demonstrated that the CM/SLN/Ce6 showed 
      a better anticancer outcome compared to SLN/Ce6. Conclusion: CM/SLN/Ce6 might be 
      a promising platform for effective tumor targeted PDT of gastric cancer.
FAU - Yang, Jiaxing
AU  - Yang J
AD  - Department of Gastrointestinal Surgery, The First Hospital of Jilin University, 
      Changchun, Jilin, People's Republic of China.
FAU - Teng, Yongliang
AU  - Teng Y
AD  - Department of Pathology, The First Hospital of Jilin University, Changchun, 
      Jilin, People's Republic of China.
FAU - Fu, Yu
AU  - Fu Y
AD  - Department of Radiology, The First Hospital of Jilin University, Changchun, 
      Jilin, People's Republic of China.
FAU - Zhang, Chunyu
AU  - Zhang C
AD  - Department of Radiology, The First Hospital of Jilin University, Changchun, 
      Jilin, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20190709
PL  - New Zealand
TA  - Int J Nanomedicine
JT  - International journal of nanomedicine
JID - 101263847
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Chlorophyllides)
RN  - 0 (Colloids)
RN  - 0 (Porphyrins)
RN  - 0 (Reactive Oxygen Species)
RN  - 5S2CCF3T1Z (phytochlorin)
RN  - 7631-86-9 (Silicon Dioxide)
SB  - IM
MH  - Animals
MH  - Antineoplastic Agents/pharmacology/therapeutic use
MH  - Body Weight/drug effects
MH  - Cell Death/drug effects
MH  - Cell Line, Tumor
MH  - Cell Membrane/drug effects/*pathology
MH  - Chlorophyllides
MH  - Colloids
MH  - Drug Delivery Systems
MH  - Drug Liberation
MH  - Humans
MH  - Mice
MH  - Nanoparticles/*chemistry/ultrastructure
MH  - Particle Size
MH  - *Photochemotherapy
MH  - Porphyrins/pharmacology/*therapeutic use
MH  - Reactive Oxygen Species/metabolism
MH  - Silicon Dioxide/*chemistry
MH  - Static Electricity
MH  - Stomach Neoplasms/*drug therapy/*pathology
MH  - Tissue Distribution/drug effects
MH  - Tumor Burden/drug effects
PMC - PMC6628142
OTO - NOTNLM
OT  - cell membrane
OT  - chlorins e6
OT  - gastric cancer
OT  - photodynamic therapy
OT  - silica nanoparticles
COIS- The authors report no conflicts of interest in this work.
EDAT- 2019/08/03 06:00
MHDA- 2019/10/12 06:00
PMCR- 2019/07/09
CRDT- 2019/08/03 06:00
PHST- 2019/01/25 00:00 [received]
PHST- 2019/05/03 00:00 [accepted]
PHST- 2019/08/03 06:00 [entrez]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2019/10/12 06:00 [medline]
PHST- 2019/07/09 00:00 [pmc-release]
AID - 202910 [pii]
AID - 10.2147/IJN.S202910 [doi]
PST - epublish
SO  - Int J Nanomedicine. 2019 Jul 9;14:5061-5071. doi: 10.2147/IJN.S202910. 
      eCollection 2019.