PMID- 31372016
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 12
DP  - 2019
TI  - Sarcopenia and type 2 diabetes mellitus: a bidirectional relationship.
PG  - 1057-1072
LID - 10.2147/DMSO.S186600 [doi]
AB  - The incidence and prevalence of metabolic and musculoskeletal diseases are 
      increasing. Type 2 diabetes mellitus (T2DM) is characterized by insulin 
      resistance, inflammation, advanced glycation end-product accumulation and 
      increased oxidative stress. These characteristics can negatively affect various 
      aspects of muscle health, including muscle mass, strength, quality and function 
      through impairments in protein metabolism, vascular and mitochondrial 
      dysfunction, and cell death. Sarcopenia is a term used to describe the 
      age-related loss in skeletal muscle mass and function and has been implicated as 
      both a cause and consequence of T2DM. Sarcopenia may contribute to the 
      development and progression of T2DM through altered glucose disposal due to low 
      muscle mass, and also increased localized inflammation, which can arise through 
      inter- and intramuscular adipose tissue accumulation. Lifestyle modifications are 
      important for improving and maintaining mobility and metabolic health in 
      individuals with T2DM and sarcopenia. However, evidence for the most effective 
      and feasible exercise and dietary interventions in this population is lacking. In 
      this review, we discuss the current literature highlighting the bidirectional 
      relationship between T2DM and sarcopenia, highlight current research gaps and 
      treatments, and provide recommendations for future research.
FAU - Mesinovic, Jakub
AU  - Mesinovic J
AD  - Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of 
      Medicine, Nursing and Health Sciences, Monash University, Clayton, Melbourne, 
      VIC, Australia.
FAU - Zengin, Ayse
AU  - Zengin A
AD  - Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of 
      Medicine, Nursing and Health Sciences, Monash University, Clayton, Melbourne, 
      VIC, Australia.
FAU - De Courten, Barbora
AU  - De Courten B
AD  - Monash Centre for Health Research and Implementation, School of Public Health and 
      Preventive Medicine, Monash University, Clayton, Melbourne, VIC, Australia.
FAU - Ebeling, Peter R
AU  - Ebeling PR
AD  - Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of 
      Medicine, Nursing and Health Sciences, Monash University, Clayton, Melbourne, 
      VIC, Australia.
AD  - Australian Institute for Musculoskeletal Science (AIMSS), Department of Medicine 
      - Western Health, Melbourne Medical School, The University of Melbourne, St 
      Albans, Melbourne, VIC, Australia.
FAU - Scott, David
AU  - Scott D
AD  - Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of 
      Medicine, Nursing and Health Sciences, Monash University, Clayton, Melbourne, 
      VIC, Australia.
AD  - Australian Institute for Musculoskeletal Science (AIMSS), Department of Medicine 
      - Western Health, Melbourne Medical School, The University of Melbourne, St 
      Albans, Melbourne, VIC, Australia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190708
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC6630094
OTO - NOTNLM
OT  - metabolic health
OT  - muscle health
OT  - obesity
OT  - sarcopenia
OT  - type 2 diabetes mellitus
COIS- JM is supported by a Research Training Program Scholarship. BDC is supported by 
      a National Heart Foundation Future Leader Fellowship (100864). DS is supported by 
      a National Health and Medical Research Council R.D. Wright Biomedical Career 
      Development Fellowship (GNT1123014). The authors report no other conflicts of 
      interest in this work.
EDAT- 2019/08/03 06:00
MHDA- 2019/08/03 06:01
PMCR- 2019/07/08
CRDT- 2019/08/03 06:00
PHST- 2019/03/08 00:00 [received]
PHST- 2019/05/07 00:00 [accepted]
PHST- 2019/08/03 06:00 [entrez]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2019/08/03 06:01 [medline]
PHST- 2019/07/08 00:00 [pmc-release]
AID - 186600 [pii]
AID - 10.2147/DMSO.S186600 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2019 Jul 8;12:1057-1072. doi: 10.2147/DMSO.S186600. 
      eCollection 2019.