PMID- 31373119
OWN - NLM
STAT- MEDLINE
DCOM- 20210811
LR  - 20210811
IS  - 1369-1600 (Electronic)
IS  - 1355-6215 (Linking)
VI  - 25
IP  - 5
DP  - 2020 Sep
TI  - Regional changes in ∆FosB expression in rat brain following MDMA 
      self-administration predict increased sensitivity to effects of locally infused 
      MDMA.
PG  - e12814
LID - 10.1111/adb.12814 [doi]
AB  - Repeated exposure to drugs produces a plethora of persistent brain changes, some 
      of which underlie the development of drug addiction. An important objective of 
      addiction research is to identify the brain changes that might mediate the 
      transition from drug use to drug misuse. The persistent accumulation of the 
      transcription factor, ∆FosB, following repeated drug exposure provides a means of 
      achieving this objective. Experiments were conducted on sexually mature male 
      Sprague-Dawley rats. The effects of extensive 3,4-methylenedioxymethamphetamine 
      (MDMA) self-administration on immunohistochemical measurements of ∆FosB 
      accumulation in 12 brain regions was compared with a matched, drug-naive, control 
      group. Other groups were pretreated with MDMA (0.0 or 10.0 mg/kg, ip, once daily 
      for 5 days), and the locomotor-activating effect of MDMA (200 mug/side) 
      microinjected bilaterally into brain regions selected on the basis of the ∆FosB 
      results was subsequently determined. MDMA self-administration significantly 
      increased ∆FosB expression in the nucleus accumbens core, ventromedial and 
      dorsomedial caudate-putamen, anterior cingulate, prelimbic, infralimbic, and 
      orbitofrontal cortex, and both the central and basolateral amygdala, but not in 
      the ventrolateral or dorsolateral caudate-putamen. Increases in the nucleus 
      accumbens shell were substantial but were not significant following statistical 
      correction for multiple comparisons. MDMA pretreatment enhanced MDMA-produced 
      hyperactivity only when administered into the nucleus accumbens or the medial, 
      but not the lateral, caudate-putamen, mirroring the ∆FosB results. These data 
      compare favorably to results following repeated exposure to other drugs of abuse 
      and support the idea of common neuroplastic changes following repeated drug 
      exposure.
CI  - (c) 2019 Society for the Study of Addiction.
FAU - van de Wetering, Ross
AU  - van de Wetering R
AUID- ORCID: 0000-0002-1387-444X
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
FAU - Schenk, Susan
AU  - Schenk S
AUID- ORCID: 0000-0002-7786-8313
AD  - School of Psychology, Victoria University of Wellington, Wellington, New Zealand.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190801
PL  - United States
TA  - Addict Biol
JT  - Addiction biology
JID - 9604935
RN  - 0 (Adrenergic Uptake Inhibitors)
RN  - 0 (Proto-Oncogene Proteins c-fos)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Adrenergic Uptake Inhibitors/*administration & dosage/pharmacology
MH  - Animals
MH  - Brain/*drug effects
MH  - Disease Models, Animal
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*administration & dosage/pharmacology
MH  - Proto-Oncogene Proteins c-fos/*genetics
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Self Administration
MH  - Substance-Related Disorders/*physiopathology
OTO - NOTNLM
OT  - MDMA
OT  - addiction
OT  - hyperactivity
OT  - local infusion
OT  - self-administration
OT  - DeltaFosB
EDAT- 2019/08/03 06:00
MHDA- 2021/08/12 06:00
CRDT- 2019/08/03 06:00
PHST- 2019/03/20 00:00 [received]
PHST- 2019/05/27 00:00 [revised]
PHST- 2019/07/03 00:00 [accepted]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2021/08/12 06:00 [medline]
PHST- 2019/08/03 06:00 [entrez]
AID - 10.1111/adb.12814 [doi]
PST - ppublish
SO  - Addict Biol. 2020 Sep;25(5):e12814. doi: 10.1111/adb.12814. Epub 2019 Aug 1.