PMID- 31374016
OWN - NLM
STAT- MEDLINE
DCOM- 20190813
LR  - 20231013
IS  - 1536-5964 (Electronic)
IS  - 0025-7974 (Print)
IS  - 0025-7974 (Linking)
VI  - 98
IP  - 31
DP  - 2019 Aug
TI  - Association between CYP1A1 rs4646903 T > C genetic variations and male 
      infertility risk: A meta-analysis.
PG  - e16543
LID - 10.1097/MD.0000000000016543 [doi]
LID - e16543
AB  - BACKGROUND: Number of studies have been performed to investigate the relationship 
      between the CYP1A1 rs4646903 polymorphism and male infertility risk, but the 
      sample size was small and the results were conflicting. A meta-analysis was 
      performed to assess these associations. METHODS: A systematic search was 
      conducted to identify all relevant studies from Medline, Web of science, Embase, 
      China biology medical literature database (CBM), China National Knowledge 
      Infrastructure (CNKI), WanFang and Weipu (VIP) databases up to June 30, 2018. The 
      odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess 
      the strength of associations. All of the statistical analyses were conducted 
      using Revman 5.3 and Stata 14.0. RESULTS: Ten studies involved 3028 cases and 
      3258 controls. Overall, significant association was observed between the CYP1A1 
      rs4646903 polymorphism and male infertility (C vs T: OR = 1.42, 
      95%CI = 1.14-1.76; CC vs TT: OR = 2.13, 95%CI = 1.36-3.34; CC vs CT+TT: 
      OR = 1.96, 95%CI = 1.30-2.95; CC+CT vs TT: OR = 1.51, 95%CI = 1.16-1.97). In 
      subgroup analysis by ethnic group, a statistically significant association was 
      observed in Asians (C vs T: OR = 1.59, 95%CI = 1.22-2.08), but not in Non-Asians 
      (C vs T: OR = 1.01, 95%CI = 0.79-1.30). Additionally, none of the individual 
      studies significantly affected the association between CYP1A1 rs4646903 
      polymorphism and male infertility, according to sensitivity analysis. CONCLUSION: 
      Our meta-analysis supports that the CYP1A1 rs4646903 polymorphism might 
      contribute to individual susceptibility to male infertility in Asians.
FAU - Cao, DeHong
AU  - Cao D
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University, Chengdu.
FAU - Ren, ZhengJu
AU  - Ren Z
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University, Chengdu.
FAU - Lu, DongLiang
AU  - Lu D
FAU - Liu, LiangRen
AU  - Liu L
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University, Chengdu.
FAU - Xu, Peng
AU  - Xu P
AD  - Department of Urology.
FAU - Zhang, Qin
AU  - Zhang Q
AD  - Department of Radiology, Chongqing Traditional Chinese Medicine Hospital, 
      Chongqing, China.
FAU - Wei, Qiang
AU  - Wei Q
AD  - Department of Urology, Institute of Urology, West China Hospital, Sichuan 
      University, Chengdu.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - United States
TA  - Medicine (Baltimore)
JT  - Medicine
JID - 2985248R
RN  - EC 1.14.14.1 (CYP1A1 protein, human)
RN  - EC 1.14.14.1 (Cytochrome P-450 CYP1A1)
SB  - IM
EIN - Medicine (Baltimore). 2019 Aug;98(35):e17084. PMID: 31464968
MH  - Cytochrome P-450 CYP1A1/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Infertility, Male/*etiology/*genetics
MH  - Male
MH  - Odds Ratio
PMC - PMC6709244
COIS- DC, ZR, LL, PX, and QZ declare that they have no conflicts of interest.
EDAT- 2019/08/03 06:00
MHDA- 2019/08/14 06:00
PMCR- 2019/08/02
CRDT- 2019/08/03 06:00
PHST- 2019/08/03 06:00 [entrez]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2019/08/14 06:00 [medline]
PHST- 2019/08/02 00:00 [pmc-release]
AID - 00005792-201908020-00014 [pii]
AID - MD-D-18-09670 [pii]
AID - 10.1097/MD.0000000000016543 [doi]
PST - ppublish
SO  - Medicine (Baltimore). 2019 Aug;98(31):e16543. doi: 10.1097/MD.0000000000016543.