PMID- 31374194 OWN - NLM STAT- MEDLINE DCOM- 20200413 LR - 20200413 IS - 1875-9777 (Electronic) IS - 1875-9777 (Linking) VI - 25 IP - 2 DP - 2019 Aug 1 TI - Cutting Off Leukemogenesis: Hydra-like Plasticity of Mature Leukemic Cells. PG - 167-168 LID - S1934-5909(19)30303-0 [pii] LID - 10.1016/j.stem.2019.07.005 [doi] AB - Leukemic stem cells (LSCs) in acute myeloid leukemia (AML) can drive tumor growth and relapse. In this issue of Cell Stem Cell, McKenzie et al. (2019) report that some mature leukemic cells can de-differentiate and contribute to AML tumorigenesis, a finding with important implications for therapies focused on eradicating LSCs. CI - Copyright (c) 2019 Elsevier Inc. All rights reserved. FAU - Bamezai, Shiva AU - Bamezai S AD - Institute of Experimental Cancer Research, CCC Ulm, University Hospital Ulm, Ulm, Germany. FAU - Buske, Christian AU - Buske C AD - Institute of Experimental Cancer Research, CCC Ulm, University Hospital Ulm, Ulm, Germany. Electronic address: christian.buske@uni-ulm.de. LA - eng PT - Comment PT - Journal Article PL - United States TA - Cell Stem Cell JT - Cell stem cell JID - 101311472 SB - IM CON - Cell Stem Cell. 2019 Aug 1;25(2):258-272.e9. PMID: 31374198 MH - Animals MH - Carcinogenesis MH - Cell Differentiation MH - *Hydra MH - *Leukemia, Myeloid, Acute EDAT- 2019/08/03 06:00 MHDA- 2020/04/14 06:00 CRDT- 2019/08/03 06:00 PHST- 2019/08/03 06:00 [entrez] PHST- 2019/08/03 06:00 [pubmed] PHST- 2020/04/14 06:00 [medline] AID - S1934-5909(19)30303-0 [pii] AID - 10.1016/j.stem.2019.07.005 [doi] PST - ppublish SO - Cell Stem Cell. 2019 Aug 1;25(2):167-168. doi: 10.1016/j.stem.2019.07.005.