PMID- 31374324
OWN - NLM
STAT- MEDLINE
DCOM- 20200928
LR  - 20200928
IS  - 1872-7972 (Electronic)
IS  - 0304-3940 (Linking)
VI  - 711
DP  - 2019 Oct 15
TI  - URB597 ameliorates the deleterious effects induced by binge alcohol consumption 
      in adolescent rats.
PG  - 134408
LID - S0304-3940(19)30511-7 [pii]
LID - 10.1016/j.neulet.2019.134408 [doi]
AB  - Heavy episodic drinking or binge drinking during adolescence may elicit serious 
      neurotoxic consequences in cerebral areas (e.g., the prefrontal cortex, i.e., 
      PFC) and the hippocampus, delay the maturation of the brain and increase the 
      probability of drug abuse and dependence. The endocannabinoid system plays an 
      important role in neuroprotection by reducing oxidative stress and 
      neuroinflammation. In the present study, we aimed to investigate whether URB597, 
      an inhibitor of the metabolic enzyme of the endocannabinoid anandamide (AEA), 
      altered the effects of acute and chronic alcohol administration beginning during 
      rat adolescence on recognition memory, neuroinflammation and brain-derived 
      neurotrophic factor (BDNF) levels. The animals received intraperitoneal 
      injections of URB597 (0.3 mg/Kg) or vehicle followed by the oral administration 
      of ethanol (3 or 6 g/Kg) or distilled water for 3 consecutive days in one week 
      (acute binging) or over 4 weeks (chronic binging). The groups were submitted to 
      the novel object recognition task, and their PFCs and hippocampi were removed for 
      analyses of the cytokine and BDNF levels. URB597 potentiated long-term memory 
      after the 3 mg/Kg acute alcohol administration. The chronic binge alcohol 
      administration increased the interferon (IFN)-gamma and tumor necrosis factor (TNF)-alpha 
      levels in the PFC and hippocampus and the interleukin (IL)-10 and BDNF levels in 
      the PFC, and these effects were prevented by URB597. Our results indicate that 
      the neuromodulation facilitated by AEA can reduce the neuroimmune response 
      induced by the chronic administration of alcohol beginning in adolescence in 
      rats.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Bellozi, Paula M Q
AU  - Bellozi PMQ
AD  - Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, 
      MG, Brazil.
FAU - Pelicao, Renan
AU  - Pelicao R
AD  - Department of Physiological Sciences, Federal University of Espirito Santo, 
      Vitoria, ES, Brazil.
FAU - Santos, Matheus C
AU  - Santos MC
AD  - Department of Physiological Sciences, Federal University of Espirito Santo, 
      Vitoria, ES, Brazil.
FAU - Lima, Isabel V A
AU  - Lima IVA
AD  - Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, 
      MG, Brazil.
FAU - Saliba, Soraya W
AU  - Saliba SW
AD  - Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, 
      MG, Brazil.
FAU - Vieira, Erica L M
AU  - Vieira ELM
AD  - Department of Internal Medicine, Federal University of Minas Gerais, Belo 
      Horizonte, MG, Brazil.
FAU - Campos, Alline C
AU  - Campos AC
AD  - Department of Pharmacology, University of Sao Paulo, Ribeirao Preto, SP, Brazil.
FAU - Teixeira, Antonio L
AU  - Teixeira AL
AD  - Department of Internal Medicine, Federal University of Minas Gerais, Belo 
      Horizonte, MG, Brazil.
FAU - de Oliveira, Antonio C P
AU  - de Oliveira ACP
AD  - Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte, 
      MG, Brazil.
FAU - Nakamura-Palacios, Ester M
AU  - Nakamura-Palacios EM
AD  - Department of Physiological Sciences, Federal University of Espirito Santo, 
      Vitoria, ES, Brazil.
FAU - Rodrigues, Livia C M
AU  - Rodrigues LCM
AD  - Department of Physiological Sciences, Federal University of Espirito Santo, 
      Vitoria, ES, Brazil. Electronic address: livia.rodrigues@ufes.br.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190730
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 0 (Bdnf protein, rat)
RN  - 0 (Benzamides)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Carbamates)
RN  - 0 (Cytokines)
RN  - 0 (cyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl ester)
RN  - EC 3.5.- (Amidohydrolases)
RN  - EC 3.5.1.- (fatty-acid amide hydrolase)
SB  - IM
MH  - Aging
MH  - Amidohydrolases/antagonists & inhibitors
MH  - Animals
MH  - Benzamides/*pharmacology
MH  - *Binge Drinking
MH  - Brain/*drug effects/metabolism
MH  - Brain-Derived Neurotrophic Factor/drug effects/metabolism
MH  - Carbamates/*pharmacology
MH  - Cytokines/drug effects/metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
OTO - NOTNLM
OT  - Adolescence
OT  - Alcohol binging
OT  - Endocannabinoid system
OT  - Neuroinflammation
OT  - URB597
EDAT- 2019/08/03 06:00
MHDA- 2020/09/29 06:00
CRDT- 2019/08/03 06:00
PHST- 2019/01/24 00:00 [received]
PHST- 2019/07/16 00:00 [revised]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/03 06:00 [pubmed]
PHST- 2020/09/29 06:00 [medline]
PHST- 2019/08/03 06:00 [entrez]
AID - S0304-3940(19)30511-7 [pii]
AID - 10.1016/j.neulet.2019.134408 [doi]
PST - ppublish
SO  - Neurosci Lett. 2019 Oct 15;711:134408. doi: 10.1016/j.neulet.2019.134408. Epub 
      2019 Jul 30.