PMID- 31374399 OWN - NLM STAT- MEDLINE DCOM- 20200916 LR - 20210110 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 24 DP - 2019 TI - White matter impairment in type 2 diabetes mellitus with and without microvascular disease. PG - 101945 LID - S2213-1582(19)30295-5 [pii] LID - 10.1016/j.nicl.2019.101945 [doi] LID - 101945 AB - BACKGROUND AND OBJECTIVE: Type 2 diabetes mellitus (T2DM) is a serious public health problem, and the phenomenon of T2DM occurring in younger people has directed more attention to functional changes in the brain. In this study, the microstructural integrity of white matter (WM) was evaluated in three groups of middle-aged subjects: healthy controls (HCs) and T2DM patients with and without peripheral microvascular complications (T2DM-C and T2DM-NC patients, respectively). METHODS: Diffusion tensor imaging (DTI) and related clinical examinations were performed in 66 subjects, including 20 T2DM-C patients, 20 T2DM-NC patients, 26 age- and sex-matched HCs. Magnetic resonance imaging (MRI) at 3 T was used to perform DTI; then, FSL and tract-based spatial statistics (TBSS) software were used to assess differences in the fractional anisotropy (FA) and mean diffusivity (MD) among the groups. The use of the FA and MD as parameters was evaluated by receiver operating characteristic (ROC) curve analysis. RESULTS: There were no significant differences in sex or age among the groups, and the clinical data of the groups met the experimental requirements. There was no significant difference in the FA values between the HCs and T2DM-NC groups. Compared with the HCs, the T2DM-C patients showed decreased FA values and increased MD values in the corpus callosum, bilateral anterior limb of the internal capsule, right retrolenticular part of the internal capsule, bilateral posterior thalamic radiation, right superior longitudinal fasciculus, bilateral superior corona radiata and left middle frontal gyrus (P < .01). Compared with the T2DM-NC patients, the T2DM-C patients showed decreased FA values and increased MD values in the corpus callosum, bilateral fornix, right retrolenticular part of the internal capsule, middle cerebral peduncle, right superior longitudinal fasciculus, right posterior thalamic radiation, and left middle frontal gyrus (P < .01). CONCLUSIONS: This study indicates that WM impairment is present in T2DM patients and may be related to microvascular complications. More importantly, this study also shows that such impairment may be diagnosed using the DTI mode of functional MRI before it can be diagnosed clinically. CI - Copyright (c) 2019 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Zhuo, Yaoyao AU - Zhuo Y AD - Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China; Department of Radiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 200000, PR China. FAU - Fang, Fang AU - Fang F AD - Department of Endocrinology and Metabolic Diseases, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200020, PR China. FAU - Lu, Lunbo AU - Lu L AD - Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China. FAU - Li, Ting AU - Li T AD - Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China. FAU - Lian, Jingge AU - Lian J AD - Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China. FAU - Xiong, Yun AU - Xiong Y AD - School of Computer Science and Technology, Fudan University, Shanghai Key Laboratory of Data Science, Shanghai, PR China. FAU - Kong, Dexing AU - Kong D AD - School of Mathematical Sciences, Zhejiang University, Zhejiang 310027, PR China. FAU - Li, Kangan AU - Li K AD - Department of Radiology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200080, PR China. Electronic address: Kangan.li@shsmu.edu.cn. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20190718 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 SB - IM MH - Adult MH - Anisotropy MH - Brain/*blood supply/*diagnostic imaging/pathology MH - Case-Control Studies MH - Cross-Sectional Studies MH - Diabetes Mellitus, Type 2/*diagnostic imaging/pathology MH - Diffusion Tensor Imaging/methods MH - Female MH - Humans MH - Magnetic Resonance Imaging/methods MH - Male MH - Microvessels/*diagnostic imaging/pathology MH - Middle Aged MH - White Matter/*diagnostic imaging/pathology PMC - PMC6676007 OTO - NOTNLM OT - Diffusion tensor imaging OT - Functional magnetic resonance imaging OT - Middle age OT - Type 2 diabetes mellitus OT - White matter impairment COIS- The authors report no conflicts of interest. EDAT- 2019/08/03 06:00 MHDA- 2020/09/17 06:00 PMCR- 2019/07/18 CRDT- 2019/08/03 06:00 PHST- 2018/10/08 00:00 [received] PHST- 2019/05/09 00:00 [revised] PHST- 2019/07/17 00:00 [accepted] PHST- 2019/08/03 06:00 [pubmed] PHST- 2020/09/17 06:00 [medline] PHST- 2019/08/03 06:00 [entrez] PHST- 2019/07/18 00:00 [pmc-release] AID - S2213-1582(19)30295-5 [pii] AID - 101945 [pii] AID - 10.1016/j.nicl.2019.101945 [doi] PST - ppublish SO - Neuroimage Clin. 2019;24:101945. doi: 10.1016/j.nicl.2019.101945. Epub 2019 Jul 18.