PMID- 31374966
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 8
IP  - 8
DP  - 2019 Aug 1
TI  - CD45RC Expression of Circulating CD8(+) T Cells Predicts Acute Allograft 
      Rejection: A Cohort Study of 128 Kidney Transplant Patients.
LID - 10.3390/jcm8081147 [doi]
LID - 1147
AB  - Predictive biomarkers of acute rejection (AR) are lacking. Pre-transplant 
      expression of CD45RC on blood CD8(+) T cells has been shown to predict AR in 
      kidney transplant (KT) patients. The objective of the present study was to study 
      CD45RC expression in a large cohort of KT recipients exposed to modern 
      immunosuppressive regimens. CD45RC expression on T cells was analyzed in 128 KT 
      patients, where 31 patients developed AR, of which 24 were found to be T-cell 
      mediated (TCMR). Pre-transplant CD4(+) and CD8(+) CR45RC(high) T cell proportions 
      were significantly higher in patients with AR. The frequency of CD45RC(high) T 
      cells was significantly associated with age at transplantation but was not 
      significantly different according to gender, history of transplantation, 
      pre-transplant immunization, and de novo donor specific anti-Human Leucocyte 
      Antigen (HLA) antibody. Survival-free AR was significantly better in patients 
      with CD8(+) CD45RC(high) T cells below 58.4% (p = 0.0005), but not different 
      according to CD4(+) T cells (p = 0.073). According to multivariate analysis, 
      CD8(+) CD45RC(high) T cells above 58.4% increased the risk of AR 4-fold (HR 3.96, 
      p = 0.003). Thus, pre-transplant CD45RC expression on CD8(+) T cells predicted 
      AR, mainly TCMR, in KT patients under modern immunosuppressive therapies. We 
      suggest that CD45RC expression should be evaluated in a prospective study to 
      validate its usefulness to quantify the pre-transplant risk of AR.
FAU - Lemerle, Marie
AU  - Lemerle M
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
FAU - Garnier, Anne-Sophie
AU  - Garnier AS
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
FAU - Planchais, Martin
AU  - Planchais M
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
FAU - Brilland, Benoit
AU  - Brilland B
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
AD  - Service d'Immunologie et d'Allergologie, CHU Angers, 49000 Angers, France.
FAU - Subra, Jean-Francois
AU  - Subra JF
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
AD  - CRCINA, INSERM, Universite de Nantes, Universite d'Angers, 49100 Angers, France.
FAU - Blanchet, Odile
AU  - Blanchet O
AD  - Centre de ressources biologiques, BB-0033-00038, Universite d'Angers, CHU 
      d'Angers, 49000 Angers, France.
FAU - Blanchard, Simon
AU  - Blanchard S
AD  - CRCINA, INSERM, Universite de Nantes, Universite d'Angers, 49100 Angers, France.
FAU - Croue, Anne
AU  - Croue A
AD  - Departement de Pathologie Cellulaire et Tissulaire, CHU d'Angers, 49000 Angers, 
      France.
FAU - Duveau, Agnes
AU  - Duveau A
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France.
FAU - Augusto, Jean-Francois
AU  - Augusto JF
AD  - Service de Nephrologie-Dialyse-Transplantation, CHU Angers, 49000 Angers, France. 
      jfaugusto@chu-angers.fr.
AD  - CRCINA, INSERM, Universite de Nantes, Universite d'Angers, 49100 Angers, France. 
      jfaugusto@chu-angers.fr.
LA  - eng
PT  - Journal Article
DEP - 20190801
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC6723395
OTO - NOTNLM
OT  - CD45RC
OT  - acute rejection
OT  - kidney transplantation
OT  - lymphocyte
COIS- The authors declare no conflict of interest.
EDAT- 2019/08/04 06:00
MHDA- 2019/08/04 06:01
PMCR- 2019/08/01
CRDT- 2019/08/04 06:00
PHST- 2019/06/22 00:00 [received]
PHST- 2019/07/27 00:00 [revised]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/04 06:00 [entrez]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2019/08/04 06:01 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - jcm8081147 [pii]
AID - jcm-08-01147 [pii]
AID - 10.3390/jcm8081147 [doi]
PST - epublish
SO  - J Clin Med. 2019 Aug 1;8(8):1147. doi: 10.3390/jcm8081147.