PMID- 31374992
OWN - NLM
STAT- MEDLINE
DCOM- 20200831
LR  - 20200831
IS  - 1999-4915 (Electronic)
IS  - 1999-4915 (Linking)
VI  - 11
IP  - 8
DP  - 2019 Aug 1
TI  - Genetic Markers Associated with Field PRRSV-Induced Abortion Rates.
LID - 10.3390/v11080706 [doi]
LID - 706
AB  - In gilts and sows, the more severe clinical manifestation of porcine reproductive 
      and respiratory syndrome virus (PRRSV) occurs in late gestation and can result in 
      up to a 40% abortion incidence. Despite the known genetic component in resilience 
      to PRRSV, there is scarce information regarding the abortive outcome of this 
      disease. We tested the relationship between eight molecular markers (six from 
      published studies and two identified in the present study in the HDAC6 gene) and 
      the probability of abortion during a PRRSV outbreak, using data from two 
      commercial Landrace x Large White sow farms with an incidence of abortion of 35% 
      and 17%. From the markers tested, USP18_-1533G>A did not segregate in these 
      populations, and CD163_c.3534C>T and HDAC6_g.2360C>T did not affect the abortion 
      rate. In contrast, the minor allele of two markers in SSC4 (WUR1000125 in GBP1 
      and rs340943904 in GBP5), which lower viremia in growing pigs, and the major 
      alleles of CD163_rs1107556229 and HDAC6_rs325981825 were associated with a lower 
      probability of abortion during PRRSV outbreaks. The more striking result was for 
      the MX1 gene, where the odds ratio of aborting versus not aborting was nine times 
      lower in the sows homozygous for a 275-bp insertion than in the other genotypes. 
      Interactions between markers were not relevant. All together, we bring here the 
      first evidence that mutations in the host genome can predispose or protect from 
      complete reproductive failure in sows infected with PRRSV.
FAU - Pena, Ramona N
AU  - Pena RN
AD  - Departament de Ciencia Animal, Universitat de Lleida - AGROTECNIO Centre, 25198 
      Lleida, Spain.
FAU - Fernandez, Carlos
AU  - Fernandez C
AD  - INZAR, SL, 50840 Zaragoza, Spain.
FAU - Blasco-Felip, Maria
AU  - Blasco-Felip M
AD  - Free-lance Veterinarian, 50001 Zaragoza, Spain.
FAU - Fraile, Lorenzo J
AU  - Fraile LJ
AD  - Departament de Ciencia Animal, Universitat de Lleida - AGROTECNIO Centre, 25198 
      Lleida, Spain. lorenzo.fraile@ca.udl.cat.
FAU - Estany, Joan
AU  - Estany J
AD  - Departament de Ciencia Animal, Universitat de Lleida - AGROTECNIO Centre, 25198 
      Lleida, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190801
PL  - Switzerland
TA  - Viruses
JT  - Viruses
JID - 101509722
RN  - 0 (Genetic Markers)
SB  - IM
MH  - Abortion, Septic/epidemiology/genetics/*veterinary
MH  - Alleles
MH  - Animals
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Markers/genetics
MH  - Genotype
MH  - Incidence
MH  - Mutation
MH  - Polymorphism, Genetic
MH  - Porcine Reproductive and Respiratory Syndrome/*epidemiology/*genetics
MH  - Porcine respiratory and reproductive syndrome virus
MH  - Pregnancy
MH  - Sus scrofa
MH  - Swine
PMC - PMC6723062
OTO - NOTNLM
OT  - DNA markers
OT  - PRRS
OT  - abortion rate
OT  - transplacental infection
COIS- The authors declare no conflicts of interest.
EDAT- 2019/08/04 06:00
MHDA- 2020/09/01 06:00
PMCR- 2019/08/01
CRDT- 2019/08/04 06:00
PHST- 2019/07/05 00:00 [received]
PHST- 2019/07/30 00:00 [revised]
PHST- 2019/07/30 00:00 [accepted]
PHST- 2019/08/04 06:00 [entrez]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2020/09/01 06:00 [medline]
PHST- 2019/08/01 00:00 [pmc-release]
AID - v11080706 [pii]
AID - viruses-11-00706 [pii]
AID - 10.3390/v11080706 [doi]
PST - epublish
SO  - Viruses. 2019 Aug 1;11(8):706. doi: 10.3390/v11080706.