PMID- 31375651
OWN - NLM
STAT- MEDLINE
DCOM- 20200103
LR  - 20200225
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 22
IP  - 2
DP  - 2019 Aug
TI  - Clinical utility of intravascular ultrasonography-guided therapy in a 
      small-vessel coronary lesion associated with Type 2 diabetes mellitus.
PG  - 68-76
LID - 10.14744/AnatolJCardiol.2019.77009 [doi]
AB  - OBJECTIVE: It is unknown whether the intravascular ultrasound (IVUS) guidance for 
      percutaneous coronary intervention (PCI) should be routinely used in small-vessel 
      coronary lesions in patients affected by Type 2 diabetes mellitus (T2DM). This 
      study aimed to assess the clinical significance of the IVUS-guided PCI treatment 
      for small-vessel coronary lesions in T2DM. METHODS: This was a prospective 
      interventional trial. A total of 228 patients affected by T2DM with stable angina 
      and a positive stress test in the presence of coronary arteriography (CAG) 
      involving small vessels [online measurement reference vessel diameter </=3.0 mm by 
      means of quantitative coronary angiography (QCA)] were recruited and divided into 
      two groups: an IVUS-guided group (n=120) and a CAG-guided group (n=108). 
      Follow-up PCIs were performed via CAG or IVUS criteria, respectively. 
      Between-group comparisons were made for the number of stents implanted, length, 
      diameter, and high-pressure balloons used post-dilatation. Major adverse cardiac 
      events (MACEs) defined as cardiac death, nonfatal myocardial infarction, and 
      target lesion revascularization (TLR) were the primary endpoint. The value of 
      late lumen loss and proportion of in-stent restenosis (ISR) were the secondary 
      endpoint, all of which were also evaluated during the follow-up period. RESULTS: 
      There was an increased lesion length observed using the IVUS measurement when 
      compared with QCA measurements in the IVUS-guided group (p</=0.001). The number of 
      implanted stents, diameter, length, percentage of high-pressure balloons used 
      during post-dilatation, value of late lumen loss, and proportion of ISR decreased 
      in the IVUS-guided group when compared with the CAG-guided group (p=0.002, 
      p=0.001, p=0.003, p=0.004, p=0.007, p=0.001, respectively). After a 2-year 
      follow-up, the Kaplan-Meier curves indicated that the incidence of MACEs was 
      significantly lower in the IVUS-guided group (log-rank p=0.029), mainly because 
      of the TLR reduction (log-rank p=0.037). CONCLUSION: The IVUS-guided PCI 
      treatment improved the event-free survival in small-vessel coronary lesions in 
      patients affected by T2DM.
FAU - Li, Lin
AU  - Li L
AD  - Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong 
      University; Jinan-China.
FAU - Wang, Li
AU  - Wang L
AD  - Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong 
      University; Jinan-China.
FAU - Zhai, Chun-Juan
AU  - Zhai CJ
AD  - Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong 
      University; Jinan-China.
FAU - Mou, Ya-Ru
AU  - Mou YR
AD  - Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong 
      University; Jinan-China.
FAU - Wang, Jian-Hong
AU  - Wang JH
AD  - Department of Hematology, Shandong Provincial Hospital affiliated to Shandong 
      University;Jinan-China.
FAU - Cui, Lian-Qun
AU  - Cui LQ
AD  - Department of Cardiology, Shandong Provincial Hospital affiliated to Shandong 
      University; Jinan-China.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
SB  - IM
MH  - Angina, Stable/therapy
MH  - Coronary Angiography
MH  - Coronary Artery Disease/complications/diagnostic imaging/*therapy
MH  - Coronary Stenosis/complications/diagnostic imaging/therapy
MH  - Diabetes Mellitus, Type 2/*complications
MH  - Drug-Eluting Stents
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Percutaneous Coronary Intervention/*methods
MH  - Prospective Studies
MH  - Regression Analysis
MH  - Stents
MH  - Ultrasonography, Interventional
PMC - PMC6735441
COIS- Conflict of interest: None declared.
EDAT- 2019/08/04 06:00
MHDA- 2020/01/04 06:00
PMCR- 2019/01/01
CRDT- 2019/08/04 06:00
PHST- 2019/08/04 06:00 [entrez]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2020/01/04 06:00 [medline]
PHST- 2019/01/01 00:00 [pmc-release]
AID - AJC-22-68 [pii]
AID - 10.14744/AnatolJCardiol.2019.77009 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2019 Aug;22(2):68-76. doi: 10.14744/AnatolJCardiol.2019.77009.