PMID- 31376116
OWN - NLM
STAT- MEDLINE
DCOM- 20200409
LR  - 20200802
IS  - 2008-2231 (Electronic)
IS  - 1560-8115 (Print)
IS  - 1560-8115 (Linking)
VI  - 27
IP  - 2
DP  - 2019 Dec
TI  - Recent trends and advances in microbe-based drug delivery systems.
PG  - 799-809
LID - 10.1007/s40199-019-00291-2 [doi]
AB  - Since more than a decade, pharmaceutical researchers endeavor to develop an 
      effective, safe and target-specific drug delivery system to potentiate the 
      therapeutic actions and reduce the side effects. The conventional drug delivery 
      systems (DDSs) show the improvement in the lifestyle of the patients suffering 
      from non-communicable diseases, autoimmune diseases but sometimes, drug 
      resistance developed during the treatment is a major concern for clinicians to 
      find an alternative and more advanced transport systems. Advancements in drug 
      delivery facilitate the development of active carrier for targeted action with 
      improved pharmacokinetic behavior. This review article focuses on microbe-based 
      drug delivery systems to provide safe, non-toxic, site-specific targeted action 
      with lesser side effects. Pharmaceutical researchers play a vital part in 
      microbe-based drug delivery systems as a therapeutic agent and carrier. The 
      properties of microorganisms like self-propulsion, in-situ production of 
      therapeutics, penetration into the tumor cells, increase in immunity, etc. are of 
      interest for development of highly effective delivery carrier. Lactococcus lactis 
      is therapeutically helpful in Inflammatory Bowel Disease (IBD) and is under 
      investigation of phase I clinical trial. Moreover, bacteria, anti-cancer 
      oncolytic viruses, viral vectors (gene therapy) and viral immunotherapy are the 
      attractive areas of biotechnological research. Virus acts as a distinctive 
      candidate for imaging of tumor and accumulation of active in tumor. Graphical 
      abstract Classification of microbe-based drug delivery system.
FAU - Shende, Pravin
AU  - Shende P
AD  - Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's 
      NMIMS, V. L. Mehta road, Vile Parle (W), Mumbai, India. shendepravin94@gmail.com.
FAU - Basarkar, Vasavi
AU  - Basarkar V
AD  - Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's 
      NMIMS, V. L. Mehta road, Vile Parle (W), Mumbai, India.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190802
PL  - Switzerland
TA  - Daru
JT  - Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences
JID - 101125969
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
MH  - Animals
MH  - Bacterial Physiological Phenomena
MH  - Drug Delivery Systems/*methods
MH  - Fungi/physiology
MH  - Humans
MH  - Pharmaceutical Preparations/*administration & dosage
MH  - Virus Physiological Phenomena
PMC - PMC6895346
OTO - NOTNLM
OT  - Attenuated
OT  - Bacteria
OT  - Biomolecules
OT  - Tumoricidal
OT  - Virosomes
COIS- Authors declare no conflict of interest.
EDAT- 2019/08/04 06:00
MHDA- 2020/04/10 06:00
PMCR- 2020/08/02
CRDT- 2019/08/04 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/07/22 00:00 [accepted]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2020/04/10 06:00 [medline]
PHST- 2019/08/04 06:00 [entrez]
PHST- 2020/08/02 00:00 [pmc-release]
AID - 10.1007/s40199-019-00291-2 [pii]
AID - 291 [pii]
AID - 10.1007/s40199-019-00291-2 [doi]
PST - ppublish
SO  - Daru. 2019 Dec;27(2):799-809. doi: 10.1007/s40199-019-00291-2. Epub 2019 Aug 2.