PMID- 31376264
OWN - NLM
STAT- MEDLINE
DCOM- 20191007
LR  - 20191007
IS  - 0392-856X (Print)
IS  - 0392-856X (Linking)
VI  - 37 Suppl 118
IP  - 3
DP  - 2019 May-Jun
TI  - Distinct clinical characteristics of anti-Ro/SSA-negative primary Sjogren's 
      syndrome: data from a nationwide cohort for Sjogren's syndrome in Korea.
PG  - 107-113
AB  - OBJECTIVES: To investigate clinical characteristics of patients with primary 
      Sjogren's syndrome (SS) who were negative for anti-Ro/SSA antibody but positive 
      for minor salivary gland biopsy (MSGB) compared to patients who presented 
      positivity for anti-Ro/SSA antibody. METHODS: The data of 355 patients from the 
      Korean Initiative of primary Sjogren's Syndrome (KISS), a nationwide prospective 
      cohort for primary SS in Korea, were analysed. All patients fulfilled the 2016 
      American College of Rheumatology/European League Against Rheumatism (EULAR) 
      classification criteria. Of these patients, 326 were positive for anti-Ro/SSA 
      antibody and 29 were antibody-negative, although they had positive findings in 
      MSGB. Various clinical features including all kinds of tests for evaluating 
      secretory function, disease-related clinical indices and serological values 
      available in the cohort were compared between the two groups. RESULTS: The 
      anti-Ro/SSA-negative group showed less rheumatoid factor positivity (p<0.001), 
      leucopenia (p=0.003), hyper-gammaglobulinaemia (p<0.001), lower serum 
      beta2-microglobulin level (p=0.034), more anti-centromere antibody positivity 
      (p<0.001), higher score in dryness domain of EULAR SS patient-reported index 
      (p=0.048) and more positivity for peripheral nervous system domain in EULAR SS 
      disease activity index and loss of teeth in SS disease damage index (p=0.021 and 
      0.041, respectively) than patients who were positive for anti-Ro/ SSA antibody. 
      CONCLUSIONS: Primary SS patients who are negative for anti-Ro/SSA antibody have 
      different clinical characteristics compared to patients who are positive for such 
      antibody in Korea. Therefore, clinicians should consider MSGB in patients with 
      suspicious symptoms who are anti-Ro/SSA-negative.
FAU - Park, Youngjae
AU  - Park Y
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Lee, Jennifer
AU  - Lee J
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Koh, Jung Hee
AU  - Koh JH
AD  - Division of Rheumatology, Department of Internal Medicine, Bucheon St. Mary's 
      Hospital, College of Medicine, the Catholic University of Korea, Seoul, Republic 
      of Korea.
FAU - Sung, Yoon-Kyoung
AU  - Sung YK
AD  - Department of Rheumatology, Hanyang University Hospital for Rheumatic Diseases, 
      Seoul, Republic of Korea.
FAU - Lee, Shin-Seok
AU  - Lee SS
AD  - Department of Rheumatology, Chonnam National University Medical School and 
      Hospital, Gwangju, Republic of Korea.
FAU - Choe, Jung Yoon
AU  - Choe JY
AD  - Division of Rheumatology, Daegu Catholic University Medical Centre, Daegu, 
      Republic of Korea.
FAU - Shim, Seung-Cheol
AU  - Shim SC
AD  - Division of Rheumatology, Department of Internal Medicine, School of Medicine, 
      Chungnam National University, Chungnam National University Hospital, Daejeon, 
      Republic of Korea.
FAU - Kim, Ji-Min
AU  - Kim JM
AD  - Division of Rheumatology, Department of Internal Medicine, Keimyung University 
      Dongsan Medical Centre, Daegu, Republic of Korea.
FAU - Kwon, Sung Ryul
AU  - Kwon SR
AD  - Division of Rheumatology, Department of Internal Medicine, Inha University School 
      of Medicine, Incheon, Republic of Korea.
FAU - Kim, Hyun-Ok
AU  - Kim HO
AD  - Division of Rheumatology, Department of Internal Medicine, Gyeongsang National 
      University Changwon Hospital, Changwon, Republic of Korea.
FAU - Chung, So-Hyang
AU  - Chung SH
AD  - Department of Ophthalmology and Visual Science, Seoul St. Mary's Hospital, 
      College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
FAU - Park, Sung-Hwan
AU  - Park SH
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
FAU - Kwok, Seung-Ki
AU  - Kwok SK
AD  - Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's 
      Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. 
      seungki73@catholic.ac.kr.
LA  - eng
PT  - Journal Article
DEP - 20190722
PL  - Italy
TA  - Clin Exp Rheumatol
JT  - Clinical and experimental rheumatology
JID - 8308521
RN  - 0 (Antibodies, Antinuclear)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Antibodies, Antinuclear/*immunology
MH  - Humans
MH  - Prospective Studies
MH  - Republic of Korea
MH  - Rheumatoid Factor
MH  - Salivary Glands, Minor/*immunology/pathology
MH  - *Sjogren's Syndrome/diagnosis/immunology/pathology
EDAT- 2019/08/04 06:00
MHDA- 2019/10/08 06:00
CRDT- 2019/08/04 06:00
PHST- 2019/06/07 00:00 [received]
PHST- 2019/07/02 00:00 [accepted]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2019/10/08 06:00 [medline]
PHST- 2019/08/04 06:00 [entrez]
AID - 14395 [pii]
PST - ppublish
SO  - Clin Exp Rheumatol. 2019 May-Jun;37 Suppl 118(3):107-113. Epub 2019 Jul 22.