PMID- 31376650
OWN - NLM
STAT- MEDLINE
DCOM- 20200415
LR  - 20200415
IS  - 1096-0953 (Electronic)
IS  - 0013-9351 (Linking)
VI  - 176
DP  - 2019 Sep
TI  - Longitudinal study of age of menarche in association with childhood 
      concentrations of persistent organic pollutants.
PG  - 108551
LID - S0013-9351(19)30348-2 [pii]
LID - 10.1016/j.envres.2019.108551 [doi]
AB  - BACKGROUND: Age at female puberty is associated with adult morbidities, including 
      breast cancer and diabetes. Hormonally active chemicals are suspected of altering 
      pubertal timing. We examined whether persistent organic pollutants (POPs) are 
      associated with age at menarche in a longitudinal study. METHODS: We analyzed 
      data for females enrolled at age 6-8 years in the Breast Cancer and Environment 
      Research Program from California and Ohio. Participants were followed annually 
      2004-2013 and provided serum (mean age 7.8 years) for measurement of 
      polychlorinated biphenyl (PCB), organochlorine pesticide (OCP), and 
      polybrominated diphenyl ether (PBDE) concentrations. Age of menarche was assigned 
      based on parental and participant reported dates and ages of menarche. Adjusted 
      hazard ratios (aHRs) for menarchal onset were calculated with Cox proportional 
      regression. Body mass index (BMI), potentially on the causal pathway, was added 
      to parallel analyses. RESULTS: Age of menarche was later with higher summed PCB 
      levels (median 11.9 years in quartile 1 [Q1] versus 12.7 in quartile 4 [Q4]) and 
      OCP levels (12.1 years versus 12.4, respectively). When adjusting for all 
      covariates except BMI, higher POP concentrations were associated with later age 
      at menarche (Q4 versus Q1 aHRs: PBDEs 0.75 [95% CI 0.58, 0.97], PCBs 0.67 [95% CI 
      0.5, 0.89], and OCPs 0.66 [95% CI 0.50, 0.89]). Additional adjustment for BMI 
      attenuated aHRs; PCB aHR approached the null. CONCLUSION: Findings revealed later 
      onset of menarche with higher concentrations of certain POPs, possibly through an 
      association with BMI. Altered pubertal timing may have long lasting effects on 
      reproductive health and disease risk, so continued attention is important for 
      understanding the biological processes affected by hormonally active chemicals.
CI  - Copyright (c) 2019. Published by Elsevier Inc.
FAU - Attfield, Kathleen R
AU  - Attfield KR
AD  - California Department of Public Health, Richmond, CA, USA; Epidemic Intelligence 
      Service, Centers for Disease Control and Prevention, Atlanta, GA, USA. Electronic 
      address: Kathleen.Attfield@cdph.ca.gov.
FAU - Pinney, Susan M
AU  - Pinney SM
AD  - University of Cincinnati College of Medicine, Cincinnati, OH, USA.
FAU - Sjodin, Andreas
AU  - Sjodin A
AD  - Centers for Disease Control and Prevention, Atlanta, GA, USA.
FAU - Voss, Robert W
AU  - Voss RW
AD  - California Department of Public Health, Richmond, CA, USA.
FAU - Greenspan, Louise C
AU  - Greenspan LC
AD  - Kaiser Permanente, San Francisco, CA, USA.
FAU - Biro, Frank M
AU  - Biro FM
AD  - University of Cincinnati College of Medicine, Cincinnati, OH, USA.
FAU - Hiatt, Robert A
AU  - Hiatt RA
AD  - Department of Epidemiology and Biostatistics, University of California, San 
      Francisco, CA, USA.
FAU - Kushi, Lawrence H
AU  - Kushi LH
AD  - Division of Research, Kaiser Permanente, Oakland, CA, USA.
FAU - Windham, Gayle C
AU  - Windham GC
AD  - California Department of Public Health, Richmond, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20190621
PL  - Netherlands
TA  - Environ Res
JT  - Environmental research
JID - 0147621
RN  - 0 (Environmental Pollutants)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adult
MH  - California
MH  - Child
MH  - Environmental Exposure/*statistics & numerical data
MH  - *Environmental Pollutants
MH  - Female
MH  - Humans
MH  - *Hydrocarbons, Chlorinated
MH  - Longitudinal Studies
MH  - *Menarche
MH  - Ohio
MH  - *Polychlorinated Biphenyls
OTO - NOTNLM
OT  - Menarche
OT  - PBDEs
OT  - PCBs
OT  - Persistent organic chemicals
OT  - Pesticides
OT  - Puberty
EDAT- 2019/08/04 06:00
MHDA- 2020/04/16 06:00
CRDT- 2019/08/04 06:00
PHST- 2018/12/11 00:00 [received]
PHST- 2019/06/18 00:00 [revised]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/08/04 06:00 [pubmed]
PHST- 2020/04/16 06:00 [medline]
PHST- 2019/08/04 06:00 [entrez]
AID - S0013-9351(19)30348-2 [pii]
AID - 10.1016/j.envres.2019.108551 [doi]
PST - ppublish
SO  - Environ Res. 2019 Sep;176:108551. doi: 10.1016/j.envres.2019.108551. Epub 2019 
      Jun 21.