PMID- 31376676 OWN - NLM STAT- MEDLINE DCOM- 20200923 LR - 20200923 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 67-68 DP - 2019 Nov-Dec TI - Clinical use of bioelectrical impedance analysis in patients affected by myotonic dystrophy type 1: A cross-sectional study. PG - 110546 LID - S0899-9007(19)30100-5 [pii] LID - 10.1016/j.nut.2019.05.012 [doi] AB - OBJECTIVES: Myotonic dystrophy type 1 (DM1) is an inherited muscle disorder characterized by slowly progressive weakness due to muscle degeneration. The Muscular Impairment Rating Scale (MIRS) is validated to assess clinical muscle severity of patients with DM1, although the scale is not sensitive enough to assess disease progression in time intervals fit for clinical trials. The aim of this study was to analyze bioelectrical whole body and arm segmental parameters in patients with DM1 to explore a correlation between bioelectrical impedance analysis (BIA) parameters and disease stage. METHODS: Forty patients with DM1 were enrolled in a cross-sectional study. In all patients, MIRS, handgrip strength (HGS), and BIA were assessed. A Kruskal-Wallis test was used to assess the difference in continuous variables according to MIRS. Correlation between BIA values and HGS were made by Pearson's coefficient analysis. A linear regression analysis was performed. RESULTS: Eighteen of 40 patients were men (45%). The median age of the cohort was 42 y (30-58 y). Four patients (10%) were classified as MIRS 1; 20 (50%) MIRS 2; 11 (27.5%) MIRS 3; and 5 (12.5%) as MIRS 4. A correlation was observed between phase angle and MIRS (P = 0.0001). MIRS correlated with other BIA values such as resistance, impedance ratio, and capacitance (P = 0.005, P = 0.0001, P = 0.0006, respectively). At linear regression analysis, segmental resistance, phase angle, impedance ratio, and capacitance of both arms significantly correlated with HGS. CONCLUSIONS: Results from the study support the use of BIA as a suitable procedure for staging DM1 muscle involvement and as a measure of muscle disease outcome, in clinical practice and in clinical trial design of therapeutic drugs. CI - Copyright (c) 2019 Elsevier Inc. All rights reserved. FAU - Rinninella, Emanuele AU - Rinninella E AD - UOC di Nutrizione Clinica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Istituto di Patologia Speciale Medica, Universita Cattolica del Sacro Cuore, Rome, Italy. Electronic address: emanuele.rinninella@unicatt.it. FAU - Silvestri, Gabriella AU - Silvestri G AD - UOC di Neurologia, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo; Istituto di Neurologia, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Cintoni, Marco AU - Cintoni M AD - Scuola di Specializzazione in Scienza dell'Alimentazione, Universita di Roma Tor Vergata, Rome, Italy. FAU - Perna, Alessia AU - Perna A AD - UOC di Neurologia, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo; Istituto di Neurologia, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Martorana, Giuseppe Ettore AU - Martorana GE AD - UOC di Nutrizione Clinica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. FAU - De Lorenzo, Antonino AU - De Lorenzo A AD - Sezione di Nutrizione Clinica e Nutrigenomica, Dipartimento di Biomedicina e Prevenzione, Universita di Roma Tor Vergata, Rome, Italy. FAU - Rossini, Paolo Maria AU - Rossini PM AD - UOC di Neurologia, Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo; Istituto di Neurologia, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Miggiano, Giacinto Abele Donato AU - Miggiano GAD AD - UOC di Nutrizione Clinica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Istituto di Patologia Speciale Medica, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Gasbarrini, Antonio AU - Gasbarrini A AD - Istituto di Patologia Speciale Medica, Universita Cattolica del Sacro Cuore, Rome, Italy; UOC di Medicina Interna e Gastroenterologia, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy. FAU - Mele, Maria Cristina AU - Mele MC AD - UOC di Nutrizione Clinica, Dipartimento di Scienze Gastroenterologiche, Endocrino-Metaboliche e Nefro-Urologiche, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy; Istituto di Patologia Speciale Medica, Universita Cattolica del Sacro Cuore, Rome, Italy. LA - eng PT - Journal Article DEP - 20190702 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Adult MH - Cohort Studies MH - Cross-Sectional Studies MH - Disease Progression MH - *Electric Impedance MH - Female MH - Hand Strength/physiology MH - Humans MH - Male MH - Middle Aged MH - Muscle Weakness/physiopathology MH - Myotonic Dystrophy/diagnostic imaging/*physiopathology MH - Nutrition Assessment MH - Nutritional Status MH - Pilot Projects MH - Severity of Illness Index OTO - NOTNLM OT - Capacitance OT - Handgrip strength test OT - Impedance ratio OT - Muscular Impairment Rating Scale (MIRS) OT - Personalized medicine OT - Phase angle OT - Steinert's disease EDAT- 2019/08/04 06:00 MHDA- 2020/09/24 06:00 CRDT- 2019/08/04 06:00 PHST- 2018/11/19 00:00 [received] PHST- 2019/05/06 00:00 [revised] PHST- 2019/05/10 00:00 [accepted] PHST- 2019/08/04 06:00 [pubmed] PHST- 2020/09/24 06:00 [medline] PHST- 2019/08/04 06:00 [entrez] AID - S0899-9007(19)30100-5 [pii] AID - 10.1016/j.nut.2019.05.012 [doi] PST - ppublish SO - Nutrition. 2019 Nov-Dec;67-68:110546. doi: 10.1016/j.nut.2019.05.012. Epub 2019 Jul 2.