PMID- 31377033
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200928
IS  - 0928-4680 (Print)
IS  - 0928-4680 (Linking)
VI  - 26
IP  - 3-4
DP  - 2019 Sep-Dec
TI  - Camphor elicits up-regulation of hepatic and pulmonary pro-inflammatory cytokines 
      and chemokines via activation of NF-kB in rats.
PG  - 305-313
LID - S0928-4680(19)30068-9 [pii]
LID - 10.1016/j.pathophys.2019.07.005 [doi]
AB  - Consumption of camphor infusions is widely used as an aphrodisiac in preparation 
      for sexual intercourse, to boost performance. There is dearth of information 
      associating or relating its consumption to liver or lung inflammation. Therefore, 
      we investigated the effect of various doses of camphor in an acute study, on 
      hepatic and pulmonary levels of some pro-inflammatory cytokines and chemokines in 
      male wistar rats. Following administration, 2000 and 4000 mg/kg body weight 
      camphor significantly increase liver and lung levels of tumor necrosis factor 
      alpha (TNF-alpha), interleukin 1 beta (IL-1beta) and interleukin 6 (IL-6) in a dose 
      dependent manner compared with control, while interleukin 10 (IL-10) levels were 
      significantly increased only by 1000 and 4000 mg/kg body weight camphor in liver 
      and lung respectively, compared with control. Also compared with control, camphor 
      administration resulted in a significant increase in the expressions of hepatic 
      and pulmonary nuclear factor kappa B (NFkB), cyclooxygenase 2 (COX-2), regulated 
      upon activation normal T cell expressed and secreted (RANTES) or CCL5, and 
      monocyte chemo-attractant protein 1 (MCP-1) in a dose dependent manner. It is 
      therefore advised that the use and consumption of camphor should be with caution 
      as it could trigger liver and lung inflammation via activation of NF-kB and 
      up-regulation of pro-inflammatory mediators.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Somade, Oluwatobi T
AU  - Somade OT
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria. Electronic address: toblerum@yahoo.co.uk.
FAU - Ajayi, Babajide O
AU  - Ajayi BO
AD  - Department of Biochemistry, Bowen University, Iwo, Nigeria.
FAU - Tajudeen, Nurudeen O
AU  - Tajudeen NO
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - Atunlute, Eniola M
AU  - Atunlute EM
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - James, Adewale S
AU  - James AS
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
FAU - Kehinde, Samuel A
AU  - Kehinde SA
AD  - Department of Biochemistry, College of Biosciences, Federal University of 
      Agriculture, Abeokuta, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190729
PL  - Switzerland
TA  - Pathophysiology
JT  - Pathophysiology : the official journal of the International Society for 
      Pathophysiology
JID - 9433813
OTO - NOTNLM
OT  - Camphor
OT  - Chemokines
OT  - Cytokines
OT  - Hepatic
OT  - Pro-inflammation
OT  - Pulmonary
COIS- Declaration of Competing Interest None.
EDAT- 2019/08/05 06:00
MHDA- 2019/08/05 06:01
CRDT- 2019/08/05 06:00
PHST- 2019/04/10 00:00 [received]
PHST- 2019/05/08 00:00 [revised]
PHST- 2019/07/28 00:00 [accepted]
PHST- 2019/08/05 06:00 [pubmed]
PHST- 2019/08/05 06:01 [medline]
PHST- 2019/08/05 06:00 [entrez]
AID - S0928-4680(19)30068-9 [pii]
AID - 10.1016/j.pathophys.2019.07.005 [doi]
PST - ppublish
SO  - Pathophysiology. 2019 Sep-Dec;26(3-4):305-313. doi: 
      10.1016/j.pathophys.2019.07.005. Epub 2019 Jul 29.