PMID- 31380154
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2167-8359 (Print)
IS  - 2167-8359 (Electronic)
IS  - 2167-8359 (Linking)
VI  - 7
DP  - 2019
TI  - Studying the impact of young age on prognosis and treatment in laryngeal squamous 
      cell carcinomas using the SEER database.
PG  - e7368
LID - 10.7717/peerj.7368 [doi]
LID - e7368
AB  - BACKGROUND: Laryngeal squamous cell carcinoma (LSCC) in young patients was 
      reported to be more aggressive and associated with poorer survival than in older 
      patients. However, very few studies contained sufficient cases to permit 
      meaningful statistical analysis. It is still unknown whether less aggressive 
      method like radical radiotherapy (RT) is comparable to total laryngectomy (TL) in 
      survival rate among young patients. METHODS: This study extracted patient data 
      from the surveillance, epidemiology, and end results database from 2004 to 2015. 
      The findings for 304 patients (1.2%) below the age of 40 were compared with those 
      for 24,827 patients (98.8%) aged 40 or older. RESULTS: The younger cohorts 
      contained a higher proportion of female patients (33.6% vs. 19.1%, respectively), 
      had more cases of glottic involvement (64.5% vs. 53.1%), and were less likely to 
      have distant metastasis (0.7% vs.3.2%). A total of 5-year overall survival and 
      cancer-specific survival rates (CSS) in the younger patients were 86.3% and 
      88.8%, respectively, significantly better than for older patients (53.8% and 
      67.6%). Significant differences were still observed when stratified for tumor 
      stage (stage I-IV). The negative independent prognostic factors in younger 
      patients were advanced tumor stage, degree of nodal involvement, and status of 
      distant metastasis. Treatment with surgery and/or RT all produced excellent 
      outcomes in stage I-IV diseases, and radical RT resulted in survival rates equal 
      to those for TL in locally advanced LSCC among young patients (5-year CSS: 90% 
      vs. 91.5%, p = 0.99). CONCLUSION: LSCC is less aggressive and has significantly 
      better survival in younger patients. For younger patients, advanced nodal 
      involvement is the most important independent prognostic factor, and larynx 
      preservation is comparable to TL in survival rate.
FAU - Li, Ruichen
AU  - Li R
AD  - Department of Radiation Oncology, Eye, Ear, Nose & Throat Hospital of Fudan 
      University, Shanghai, China.
FAU - Yu, Shitong
AU  - Yu S
AUID- ORCID: 0000-0001-5443-2886
AD  - Department of General Surgery, Nanfang Hospital, Southern Medical University, 
      Guangzhou, China.
FAU - Zhu, Wenjia
AU  - Zhu W
AD  - Department of E.N.T, Eye, Ear, Nose & Throat Hospital of Fudan University, 
      Shanghai, China.
FAU - Wang, Shengzi
AU  - Wang S
AD  - Department of Radiation Oncology, Eye, Ear, Nose & Throat Hospital of Fudan 
      University, Shanghai, China.
FAU - Yan, Li
AU  - Yan L
AD  - Department of Radiation Oncology, Eye, Ear, Nose & Throat Hospital of Fudan 
      University, Shanghai, China.
LA  - eng
PT  - Journal Article
DEP - 20190725
PL  - United States
TA  - PeerJ
JT  - PeerJ
JID - 101603425
PMC - PMC6661153
OTO - NOTNLM
OT  - Laryngeal cancer
OT  - Larynx preservation
OT  - SEER
OT  - Survival
OT  - Younger and older patients
COIS- The authors declare that they have no competing interests.
EDAT- 2019/08/06 06:00
MHDA- 2019/08/06 06:01
PMCR- 2019/07/25
CRDT- 2019/08/06 06:00
PHST- 2019/05/10 00:00 [received]
PHST- 2019/06/27 00:00 [accepted]
PHST- 2019/08/06 06:00 [entrez]
PHST- 2019/08/06 06:00 [pubmed]
PHST- 2019/08/06 06:01 [medline]
PHST- 2019/07/25 00:00 [pmc-release]
AID - 7368 [pii]
AID - 10.7717/peerj.7368 [doi]
PST - epublish
SO  - PeerJ. 2019 Jul 25;7:e7368. doi: 10.7717/peerj.7368. eCollection 2019.