PMID- 31380250
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2228-5881 (Print)
IS  - 2251-7308 (Electronic)
IS  - 2228-5881 (Linking)
VI  - 9
IP  - 2
DP  - 2019 Jun
TI  - Formulation and Physicochemical Characterization of Cyclosporine Microfiber by 
      Electrospinning.
PG  - 249-254
LID - 10.15171/apb.2019.028 [doi]
AB  - Purpose: The objective of this study was to improve the permeability and water 
      solubility rate of a poor water soluble drug, cyclosporine A (CsA). Methods: In 
      order to improve the drug dissolution rate and oral bioavailability, 
      electrospinning method was used as an approach to prepare. The fibers were 
      evaluated for surface morphology, thermal characterizations, drug crystallinity, 
      in vitro drug release and in vivo bioavailability studies. Results: Scanning 
      electron microscope (SEM) results confirmed that the fibers were in microsize 
      range and the size of the fibers was in the rang of 0.2 to 2 micron. Differential 
      scanning calorimetry (DSC) and powder X-ray diffractometry (XRPD) analysis 
      ensured that the crystalline lattice of drug were weakened or destroyed in the 
      fibers. The drug release was 15.28%, 20.67%, and 32.84% from pure drug, fibers of 
      formulation B, and formulation A, respectively. In vivo study results indicated 
      that the bioavailability parameters of the optimized fiber formulation were 
      improved and the maximum concentration (C(max)) were significantly higher for 
      fibers (3001 ng/mL) than for pure drug (2550 ng/mL). The dissolution rate of the 
      formulations was dependent on the nature and ratio of drug to carriers. 
      Conclusion: The physicochemical properties showed that the optimized mixture of 
      polyethylene glycol (PEG) and povidone (PVP) fibers could be an effective carrier 
      for CsA delivery. PEG and PVP fibers improved the absolute bioavailability and 
      drug dissolution rate with appropriate physicochemical properties.
FAU - Mirzaeei, Shahla
AU  - Mirzaeei S
AUID- ORCID: 0000-0002-1132-3150
AD  - Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Mohammadi, Ghobad
AU  - Mohammadi G
AUID- ORCID: 0000-0002-6202-9840
AD  - Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Fattahi, Navid
AU  - Fattahi N
AUID- ORCID: 0000-0002-5781-6700
AD  - Student Research Committee, Kermanshah University of Medical Sciences, 
      Kermanshah, Iran.
FAU - Mohammadi, Pardis
AU  - Mohammadi P
AUID- ORCID: 0000-0002-4192-6737
AD  - Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Fattahi, Ali
AU  - Fattahi A
AUID- ORCID: 0000-0001-8226-5835
AD  - Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Nikbakht, Mohammad Reza
AU  - Nikbakht MR
AUID- ORCID: 0000-0001-7909-4967
AD  - Pharmaceutical Sciences Research Center, School of Pharmacy, Kermanshah 
      University of Medical Sciences, Kermanshah, Iran.
FAU - Adibkia, Khosro
AU  - Adibkia K
AUID- ORCID: 0000-0002-1053-5557
AD  - Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20190601
PL  - Iran
TA  - Adv Pharm Bull
JT  - Advanced pharmaceutical bulletin
JID - 101578021
PMC - PMC6664123
OTO - NOTNLM
OT  - Bioavailability
OT  - Cyclosporine A
OT  - Electrospinning
OT  - Fibers
OT  - Polyethylene glycol
OT  - Povidone
EDAT- 2019/08/06 06:00
MHDA- 2019/08/06 06:01
PMCR- 2019/06/01
CRDT- 2019/08/06 06:00
PHST- 2019/01/09 00:00 [received]
PHST- 2019/04/28 00:00 [revised]
PHST- 2019/05/02 00:00 [accepted]
PHST- 2019/08/06 06:00 [entrez]
PHST- 2019/08/06 06:00 [pubmed]
PHST- 2019/08/06 06:01 [medline]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.15171/apb.2019.028 [doi]
PST - ppublish
SO  - Adv Pharm Bull. 2019 Jun;9(2):249-254. doi: 10.15171/apb.2019.028. Epub 2019 Jun 
      1.