PMID- 31381466
OWN - NLM
STAT- MEDLINE
DCOM- 20210212
LR  - 20210212
IS  - 2472-6311 (Electronic)
IS  - 2472-6303 (Linking)
VI  - 25
IP  - 1
DP  - 2020 Feb
TI  - Typography-Like 3D-Printed Templates for the Lithography-Free Fabrication of 
      Microfluidic Chips.
PG  - 82-87
LID - 10.1177/2472630319867903 [doi]
AB  - Typography-like templates for polydimethylsiloxane (PDMS) microfluidic chips 
      using a fused deposition modeling (FDM) three-dimensional (3D) printer are 
      presented. This rapid and fast proposed scheme did not require complicated 
      photolithographic fabrication facilities and could deliver resolutions of ~100 
      mum. Polylactic acid (PLA) was adopted as the material to generate the 3D-printed 
      units, which were then carefully assembled on a glass substrate using a 
      heat-melt-curd strategy. This craft of bonding offers a cost-effective way to 
      design and modify the templates of microfluidic channels, thus reducing the 
      processing time of microfluidic chips. Finally, a flexible microfluidic chip to 
      be employed for cell-based drug screening was developed based on the modularized 
      3D-printed templates. The lithography-free, typography-like, 3D-printed templates 
      create a modularized fabrication process and promote the prevalence of integrated 
      microfluidic systems with minimal requirements and improved efficiency.
FAU - Su, Wenqiong
AU  - Su W
AUID- ORCID: 0000-0003-4914-346X
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Li, Yulong
AU  - Li Y
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Zhang, Lulu
AU  - Zhang L
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Sun, Jiahui
AU  - Sun J
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Liu, Shuopeng
AU  - Liu S
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
FAU - Ding, Xianting
AU  - Ding X
AD  - Institute for Personalized Medicine, State Key Laboratory of Oncogenes and 
      Related Genes, School of Biomedical Engineering, Shanghai Jiao Tong University, 
      Shanghai, China.
LA  - eng
PT  - Evaluation Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190805
PL  - United States
TA  - SLAS Technol
JT  - SLAS technology
JID - 101697564
RN  - 0 (Dimethylpolysiloxanes)
RN  - 0 (Polyesters)
RN  - 459TN2L5F5 (poly(lactide))
RN  - 63148-62-9 (baysilon)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - A549 Cells
MH  - Cisplatin
MH  - *Dimethylpolysiloxanes
MH  - Drug Screening Assays, Antitumor/*instrumentation
MH  - Humans
MH  - Microfluidic Analytical Techniques/*instrumentation
MH  - *Polyesters
MH  - *Printing, Three-Dimensional
OTO - NOTNLM
OT  - 3D printing
OT  - drug screening
OT  - lithography-free
OT  - microfluidic chip
OT  - typography-like
EDAT- 2019/08/06 06:00
MHDA- 2021/02/13 06:00
CRDT- 2019/08/06 06:00
PHST- 2019/08/06 06:00 [pubmed]
PHST- 2021/02/13 06:00 [medline]
PHST- 2019/08/06 06:00 [entrez]
AID - 10.1177/2472630319867903 [doi]
PST - ppublish
SO  - SLAS Technol. 2020 Feb;25(1):82-87. doi: 10.1177/2472630319867903. Epub 2019 Aug 
      5.