PMID- 31382183
OWN - NLM
STAT- MEDLINE
DCOM- 20200304
LR  - 20200304
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 132
DP  - 2019 Nov
TI  - Associations between persistent organic pollutants and risk of breast cancer 
      metastasis.
PG  - 105028
LID - S0160-4120(19)31495-3 [pii]
LID - 10.1016/j.envint.2019.105028 [doi]
AB  - BACKGROUND: Breast cancer (BC) is a major public health concern with over 2 
      million new cases diagnosed and over 600,000 deaths in 2018 in women worldwide. 
      When distant metastases are present at diagnosis, the 5-year survival rate is 
      only 26%. Recent studies have suggested that persistent organic pollutants (POPs) 
      that accumulate in adipose tissue (AT) can influence tumor phenotype and 
      stimulate cellular processes important for metastasis such as invasion. We, 
      therefore, tested the hypothesis that POP exposure is associated with BC 
      metastasis. METHODS: We conducted an exploratory case-control study in which the 
      concentrations of 49 POPs were measured in both AT and serum samples from BC 
      patients, with or without lymph node metastasis, who underwent partial or total 
      mastectomies, lymph node biopsies and sampling of the adipocytic tumor 
      microenvironment. Adjusted, unconditional logistic models were used to study the 
      associations between the POP concentrations and the risk of metastasis and other 
      hallmarks of cancer aggressiveness. RESULTS: 2.3.7.8-TCDD concentrations in AT 
      are positively associated with the risk of metastasis in 43 patients who have 
      BMIs equal or higher than 25 kg/m2 (odds ratio: 4.48 (1.32-20.71)). Furthermore, 
      the concentrations of 2.3.7.8-TCDD and two coplanar PCBs (77&169) in AT also were 
      positively associated with the risk of lymph node metastasis and the tumor size. 
      CONCLUSION: Our study suggests that 2.3.7.8-TCDD and some PCBs contribute to the 
      development of tumor metastasis and other hallmarks of cancer aggressiveness. 
      While these results should be considered with caution, this is the first study to 
      identify such potential risk factors. Larger longitudinal studies are necessary 
      to confirm our results. Clinical Trial Protocol Record: 2013-A00663-42.
CI  - Copyright (c) 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Koual, Meriem
AU  - Koual M
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Assistance 
      Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service de 
      Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307 Nantes, France.
FAU - Bats, Anne-Sophie
AU  - Bats AS
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Assistance 
      Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service de 
      Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Tomkiewicz, Celine
AU  - Tomkiewicz C
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Kaddouch-Amar, Yael
AU  - Kaddouch-Amar Y
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Douay-Hauser, Nathalie
AU  - Douay-Hauser N
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Assistance 
      Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service de 
      Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Ngo, Charlotte
AU  - Ngo C
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service 
      de Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite 
      de Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Bonsang, Helene
AU  - Bonsang H
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service 
      de Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite 
      de Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Delomenie, Myriam
AU  - Delomenie M
AD  - Assistance Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service 
      de Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite 
      de Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Lecuru, Fabrice
AU  - Lecuru F
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Assistance 
      Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service de 
      Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307 Nantes, France.
FAU - Marchand, Philippe
AU  - Marchand P
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307 Nantes, France.
FAU - Botton, Jeremie
AU  - Botton J
AD  - Faculty of Pharmacy, Univ. Paris-Sud, Universite Paris-Saclay, F-92296 
      Chatenay-Malabry, France.
FAU - Barouki, Robert
AU  - Barouki R
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Assistance 
      Publique-Hopitaux de Paris, Hopital Europeen Georges-Pompidou, Service de 
      Chirurgie Cancerologique Gynecologique et du Sein, Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AD  - LABERCA, Oniris, INRA, Universite Bretagne-Loire, 44307 Nantes, France.
FAU - Coumoul, Xavier
AU  - Coumoul X
AD  - INSERM UMR-S 1124, 45 rue des Saints-Peres, 75006 Paris, France; Universite de 
      Paris, 45 rue des Saints-Peres, 75006 Paris, France. Electronic address: 
      xavier.coumoul@parisdescartes.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190802
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Environmental Pollutants)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Adipose Tissue/drug effects/metabolism
MH  - Aged
MH  - Breast Neoplasms/*etiology/pathology
MH  - Case-Control Studies
MH  - Cohort Studies
MH  - Environmental Pollutants/blood/*toxicity
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Odds Ratio
MH  - Polychlorinated Biphenyls/blood/toxicity
MH  - Risk Factors
OTO - NOTNLM
OT  - Adipose tissue
OT  - Breast cancer
OT  - Dioxins
OT  - Endocrine disrupting chemicals
OT  - Environmental exposure
OT  - Organochlorine pesticides
OT  - Perfluoroalkyl acid
OT  - Polychlorinated biphenyls
OT  - Serum
EDAT- 2019/08/06 06:00
MHDA- 2020/03/05 06:00
CRDT- 2019/08/06 06:00
PHST- 2019/05/04 00:00 [received]
PHST- 2019/07/15 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/06 06:00 [pubmed]
PHST- 2020/03/05 06:00 [medline]
PHST- 2019/08/06 06:00 [entrez]
AID - S0160-4120(19)31495-3 [pii]
AID - 10.1016/j.envint.2019.105028 [doi]
PST - ppublish
SO  - Environ Int. 2019 Nov;132:105028. doi: 10.1016/j.envint.2019.105028. Epub 2019 
      Aug 2.