PMID- 31382338
OWN - NLM
STAT- MEDLINE
DCOM- 20200204
LR  - 20200204
IS  - 1873-4367 (Electronic)
IS  - 0927-7765 (Linking)
VI  - 181
DP  - 2019 Sep 1
TI  - Electron dispersive X-ray spectroscopy and degradation properties of hyaluronic 
      acid decorated microparticles.
PG  - 896-901
LID - S0927-7765(19)30450-3 [pii]
LID - 10.1016/j.colsurfb.2019.06.044 [doi]
AB  - The purpose of this study was to produce poly(DL-lactic-co-glycolic acid) (PLGA) 
      - based microparticles (MPs), externally decorated with hyaluronic acid (HA). The 
      MPs are intended for intravitreal injections in the treatment of posterior eye 
      segment and have been designed to prolong the release of growth factors into the 
      vitreous body, therefore aiming to increase the time interval between two 
      consecutive injections. The MPs, prepared by a modified double emulsion-solvent 
      evaporation technique and loaded with bovine serum albumins (BSA) and ciliary 
      neurotrophic factor (CNTF), were spherical, with a diameter around 70 mum and a 
      >90% encapsulation efficiency. Energy Dispersive Spectroscopy (EDS) outcomes 
      indicated that HA presence in the external aqueous phase of the emulsion did 
      affect the surface properties of MPs. Moreover, poloxamers drastically slowed 
      down MP degradation properties which are, in turn, closely related to their 
      ability to prolong drug release. This is promising for the envisaged application 
      of the produced MPs. Further work will be devoted to optimizing MP formulation 
      with respect to the envisaged intravitreal route of administration.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Serri, Carla
AU  - Serri C
AD  - Dipartimento di Farmacia, Universita di Napoli Federico II, Via D. Montesano 49, 
      80131, Napoli, Italy.
FAU - Frigione, Mariaenrica
AU  - Frigione M
AD  - Dipartimento di Ingegneria dell'Innovazione, Universita del Salento, S.P. 6, 
      Lecce - Monteroni, 73100, Lecce,Italy.
FAU - Ruponen, Marika
AU  - Ruponen M
AD  - School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland.
FAU - Urtti, Arto
AU  - Urtti A
AD  - School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, 
      70211 Kuopio, Finland; Centre for Drug Research, Division of Pharmaceutical 
      Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56, FI-00014 
      Helsinki, Finland.
FAU - Borzacchiello, Assunta
AU  - Borzacchiello A
AD  - Istituto per i Materiali Compositi e Biomedici (IMCB-CNR), Universita di Napoli 
      Federico II, Viale J.F. Kennedy 54, 80125, Napoli, Italy.
FAU - Biondi, Marco
AU  - Biondi M
AD  - Dipartimento di Farmacia, Universita di Napoli Federico II, Via D. Montesano 49, 
      80131, Napoli, Italy; Interdisciplinary Research Centre on Biomaterials, CRIB, 
      Universita di Napoli Federico II, P.le Tecchio, 80, 80125, Napoli, Italy. 
      Electronic address: mabiondi@unina.it.
FAU - Itkonen, Jaakko
AU  - Itkonen J
AD  - Centre for Drug Research (CDR), University of Helsinki, Yliopistonkatu 4, 00100 
      Helsinki, Finland.
FAU - Mayol, Laura
AU  - Mayol L
AD  - Dipartimento di Farmacia, Universita di Napoli Federico II, Via D. Montesano 49, 
      80131, Napoli, Italy; Interdisciplinary Research Centre on Biomaterials, CRIB, 
      Universita di Napoli Federico II, P.le Tecchio, 80, 80125, Napoli, Italy.
LA  - eng
PT  - Journal Article
DEP - 20190619
PL  - Netherlands
TA  - Colloids Surf B Biointerfaces
JT  - Colloids and surfaces. B, Biointerfaces
JID - 9315133
RN  - 0 (Ciliary Neurotrophic Factor)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 27432CM55Q (Serum Albumin, Bovine)
RN  - 9004-61-9 (Hyaluronic Acid)
SB  - IM
MH  - Animals
MH  - Cattle
MH  - Ciliary Neurotrophic Factor/chemistry
MH  - *Electrons
MH  - Hyaluronic Acid/*chemistry
MH  - Microspheres
MH  - Particle Size
MH  - Polylactic Acid-Polyglycolic Acid Copolymer/chemistry
MH  - Serum Albumin, Bovine/chemistry
MH  - *Spectrometry, X-Ray Emission
MH  - Surface Properties
OTO - NOTNLM
OT  - Diffusion
OT  - Hyaluronic acid
OT  - Microparticle
OT  - Ocular delivery
OT  - PLGA
OT  - Poloxamer
EDAT- 2019/08/07 06:00
MHDA- 2020/02/06 06:00
CRDT- 2019/08/07 06:00
PHST- 2019/03/05 00:00 [received]
PHST- 2019/05/28 00:00 [revised]
PHST- 2019/06/18 00:00 [accepted]
PHST- 2019/08/07 06:00 [entrez]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2020/02/06 06:00 [medline]
AID - S0927-7765(19)30450-3 [pii]
AID - 10.1016/j.colsurfb.2019.06.044 [doi]
PST - ppublish
SO  - Colloids Surf B Biointerfaces. 2019 Sep 1;181:896-901. doi: 
      10.1016/j.colsurfb.2019.06.044. Epub 2019 Jun 19.