PMID- 31384488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220409
IS  - 2152-6575 (Print)
IS  - 2152-6567 (Electronic)
IS  - 2152-6567 (Linking)
VI  - 10
DP  - 2019 Jan-Dec
TI  - Allergy-Related Diseases and Risk of Breast Cancer: The Role of Skewed Immune 
      System on This Association.
PG  - 2152656719860820
LID - 10.1177/2152656719860820 [doi]
LID - 2152656719860820
AB  - BACKGROUND: The role of allergy in breast cancer (BC) development remains 
      inconclusive. A comprehensive review article is required to present and discuss 
      all findings on this topic and to clarify the association between allergic 
      disorders and the risk of BC. OBJECTIVE: We aimed to explain the association 
      between atopy, different types of allergic disorders, and the risk of BC. 
      Moreover, we explored the immunological mechanism behind this association. 
      METHODS: We electronically reviewed publications in PubMed from 1979 to 2018 
      relating to atopy, allergy, asthma, atopic dermatitis, allergic rhinitis, food 
      allergy, drug allergy, immunoglobulin E (IgE) or prick test, and BC. RESULTS: 
      Most of the identified studies demonstrated nonsignificant results. However, the 
      pattern of the results indicated an increased risk of BC in individuals with a 
      history of allergies. The majority of studies reported higher prevalence of 
      atopic dermatitis and allergic rhinitis among individuals with BC compared to the 
      control groups. Similarity, most of the studies revealed an increased risk of BC 
      among people with a positive history of atopic using IgE specific or prick test. 
      However, a null association was reported in most of the asthmatic studies, and 
      controversial results were detected in the individuals with history of food and 
      drug allergies. CONCLUSION: The majority of findings were not statistically 
      significant. Moreover, bias and other methodological problems are the major 
      issues, which make it challenging to compare the findings of different studies 
      and reach a strong conclusive result. However, the pattern of the results from 
      most studies indicated that allergic diseases might be associated with an 
      increased risk of BC. Skewed immune system toward T-helper 2 might have an 
      important role in this association.
FAU - Sadeghi, Fatemeh
AU  - Sadeghi F
AUID- ORCID: 0000-0002-0018-2954
AD  - Department of Immunology, School of Medicine, Iran University of Medical 
      Sciences, Tehran, Iran.
AD  - Cancer Immunology Project (CIP), Universal Scientific Education and Research 
      Network (USERN), Tehran, Iran.
FAU - Shirkhoda, Mohammad
AU  - Shirkhoda M
AD  - Department of Surgical Oncology, Cancer Institute of Iran, Tehran University of 
      Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20190722
PL  - United States
TA  - Allergy Rhinol (Providence)
JT  - Allergy & rhinology (Providence, R.I.)
JID - 101570968
PMC - PMC6647241
OTO - NOTNLM
OT  - allergic rhinitis
OT  - allergy
OT  - asthma
OT  - atopic dermatitis
OT  - atopy
OT  - breast cancer
OT  - immunoglobulin E
EDAT- 2019/08/07 06:00
MHDA- 2019/08/07 06:01
PMCR- 2019/07/22
CRDT- 2019/08/07 06:00
PHST- 2019/08/07 06:00 [entrez]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2019/08/07 06:01 [medline]
PHST- 2019/07/22 00:00 [pmc-release]
AID - 10.1177_2152656719860820 [pii]
AID - 10.1177/2152656719860820 [doi]
PST - epublish
SO  - Allergy Rhinol (Providence). 2019 Jul 22;10:2152656719860820. doi: 
      10.1177/2152656719860820. eCollection 2019 Jan-Dec.