PMID- 31384930
OWN - NLM
STAT- MEDLINE
DCOM- 20201028
LR  - 20220410
IS  - 1532-2092 (Electronic)
IS  - 1099-5129 (Print)
IS  - 1099-5129 (Linking)
VI  - 21
IP  - 10
DP  - 2019 Oct 1
TI  - Monitoring of cerebral oximetry in patients with postural orthostatic tachycardia 
      syndrome.
PG  - 1575-1583
LID - 10.1093/europace/euz204 [doi]
AB  - AIMS: Postural orthostatic tachycardia syndrome (POTS) is a disorder of unknown 
      aetiology characterized by orthostatic intolerance and tachycardia with diverse 
      other symptoms, including neurocognitive deficits. Cerebral oximetry 
      non-invasively measures cerebral tissue saturation (SctO2) and has been shown to 
      be informative in syncope evaluation. We aimed to assess SctO2 in POTS patients 
      and those with normal response to orthostatic provocation, relative to 
      haemodynamic parameters and symptoms. METHODS AND RESULTS: Thirty-four patients 
      with POTS (29.1 +/- 9.5 years; 26 females) and 34 age-/sex-matched controls with 
      normal head-up tilt tests (HUTs) were included. SctO2 at rest and during HUT were 
      compared between POTS and controls. The relation between SctO2, systolic blood 
      pressure (SBP), and heart rate (HR) during HUT was linearly assessed. SctO2 
      values were related to dizziness or syncope during HUT. The minimum SctO2-value 
      during HUT was lower (65.4 +/- 5.6 vs. 68.2 +/- 4.2%, P = 0.023) and changes in SctO2 
      from supine to minimum HUT value were more pronounced in POTS patients 
      (-5.7 +/- 2.9% vs. -4.3 +/- 2.1%, P = 0.028). Decrease in SBP from supine to minimum 
      HUT value (P = 0.004) and increase in HR from supine to HUT value at 3 min 
      (P = 0.022) correlated with more pronounced SctO2 decrease in POTS but not 
      controls. SctO2 did not predict syncope or dizziness during HUT. CONCLUSION: 
      Postural orthostatic tachycardia syndrome patients have lower cerebral tissue 
      saturation during orthostatic provocation compared with those subjects having 
      normal haemodynamic response to tilt. Orthostatic decrease in cerebral saturation 
      only weakly correlates with HR increase and does not predict vasovagal reflex in 
      POTS. Other hitherto unknown factors may affect cerebral tissue saturation in 
      POTS.
CI  - Published on behalf of the European Society of Cardiology. All rights reserved. (c) 
      The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.
FAU - Kharraziha, Isabella
AU  - Kharraziha I
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
FAU - Holm, Hannes
AU  - Holm H
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Bachus, Erasmus
AU  - Bachus E
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
FAU - Melander, Olle
AU  - Melander O
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
FAU - Sutton, Richard
AU  - Sutton R
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - National Heart and Lung Institute, Imperial College, Hammersmith Hospital Campus, 
      London, UK.
FAU - Fedorowski, Artur
AU  - Fedorowski A
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Cardiology, Skane University Hospital, Malmo, Sweden.
FAU - Hamrefors, Viktor
AU  - Hamrefors V
AD  - Department of Clinical Sciences, Lund University, Malmo, Sweden.
AD  - Department of Internal Medicine, Skane University Hospital, Malmo, Sweden.
LA  - eng
PT  - Journal Article
PL  - England
TA  - Europace
JT  - Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal 
      of the working groups on cardiac pacing, arrhythmias, and cardiac cellular 
      electrophysiology of the European Society of Cardiology
JID - 100883649
SB  - IM
MH  - Adult
MH  - Blood Pressure/*physiology
MH  - Cerebrovascular Circulation/*physiology
MH  - Female
MH  - Follow-Up Studies
MH  - Heart Rate/*physiology
MH  - Humans
MH  - Male
MH  - Monitoring, Physiologic/*methods
MH  - Oximetry/*methods
MH  - Postural Orthostatic Tachycardia Syndrome/*diagnosis/physiopathology
MH  - Retrospective Studies
MH  - Tilt-Table Test
PMC - PMC6877984
OTO - NOTNLM
OT  - Cerebral oximetry
OT  - Haemodynamic monitoring
OT  - Head-up tilt
OT  - Orthostatic intolerance
OT  - Postural orthostatic tachycardia syndrome
EDAT- 2019/08/07 06:00
MHDA- 2020/10/29 06:00
PMCR- 2019/08/05
CRDT- 2019/08/07 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/07/11 00:00 [accepted]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2020/10/29 06:00 [medline]
PHST- 2019/08/07 06:00 [entrez]
PHST- 2019/08/05 00:00 [pmc-release]
AID - 5543874 [pii]
AID - euz204 [pii]
AID - 10.1093/europace/euz204 [doi]
PST - ppublish
SO  - Europace. 2019 Oct 1;21(10):1575-1583. doi: 10.1093/europace/euz204.