PMID- 31385029
OWN - NLM
STAT- MEDLINE
DCOM- 20200206
LR  - 20200225
IS  - 1439-6327 (Electronic)
IS  - 1439-6319 (Linking)
VI  - 119
IP  - 10
DP  - 2019 Oct
TI  - Modulation of intracortical inhibition and excitation in agonist and antagonist 
      muscles following acute strength training.
PG  - 2185-2199
LID - 10.1007/s00421-019-04203-9 [doi]
AB  - PURPOSE: Transcranial magnetic stimulation (TMS) usually investigates the 
      corticospinal responses of the agonist muscle to strength training, despite the 
      role of the antagonist muscle in strength development. We examined the 
      intracortical responses from an agonist and antagonist muscle following a single 
      session of heavy-loaded strength training (dominant-arm only) to identify the 
      early antagonistic responses to a single session that may accompany improvements 
      in strength. METHODS: Corticospinal and motor cortical excitability and 
      inhibition was collected from agonist and antagonist muscles prior to and 
      following a single session of heavy-loaded wrist flexor training in 18 
      individuals. Training consisted of four sets 6-8 repetitions at 80% of 
      1-repetition maximum (1-RM). Recruitment curves for corticospinal excitability 
      and inhibition of the right wrist flexor and wrist extensor muscles were 
      constructed and assessed by examining the area under the recruitment curve. 
      Intracortical measures were obtained using paired-pulse TMS. RESULTS: Following a 
      single training session, increases in corticospinal excitability were observed in 
      both the agonist and antagonist muscles. This was accompanied by decreases in 
      corticospinal inhibition in both muscles. Intracortical inhibition was reduced 
      and intracortical facilitation was increased for the agonist muscle only. 
      Intracortical measures in the antagonist muscle remained unchanged after 
      training. CONCLUSIONS: These findings indicate that the corticospinal responses 
      to a single session of strength training are similar between agonist and 
      antagonist muscles, but the intrinsic cortico-cortical circuitry of the 
      antagonist remains unchanged. The corticospinal responses are likely due to 
      increased involvement/co-activation of the antagonist muscle during training as 
      the agonist muscle fatigues.
FAU - Mason, Joel
AU  - Mason J
AD  - Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, 
      School of Primary and Allied Health Care, Monash University, PO Box 527, 
      Frankston, VIC, 3199, Australia.
FAU - Howatson, Glyn
AU  - Howatson G
AD  - Faculty of Health and Life Sciences, Northumbria University, Newcastle-upon-Tyne, 
      UK.
AD  - Water Research Group, School of Environmental Sciences and Development, Northwest 
      University, Potchefstroom, South Africa.
FAU - Frazer, Ashlyn K
AU  - Frazer AK
AD  - Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, 
      School of Primary and Allied Health Care, Monash University, PO Box 527, 
      Frankston, VIC, 3199, Australia.
FAU - Pearce, Alan J
AU  - Pearce AJ
AD  - School of Allied Health, La Trobe University, Melbourne, Australia.
FAU - Jaberzadeh, Shapour
AU  - Jaberzadeh S
AD  - Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, 
      School of Primary and Allied Health Care, Monash University, PO Box 527, 
      Frankston, VIC, 3199, Australia.
FAU - Avela, Janne
AU  - Avela J
AD  - Faculty of Sport and Health Sciences, Neuromuscular Research Center, University 
      of Jyvaskyla, Jyvaskyla, Finland.
FAU - Kidgell, Dawson J
AU  - Kidgell DJ
AUID- ORCID: 0000-0002-2271-1298
AD  - Department of Physiotherapy, Faculty of Medicine, Nursing and Health Sciences, 
      School of Primary and Allied Health Care, Monash University, PO Box 527, 
      Frankston, VIC, 3199, Australia. dawson.kidgell@monash.edu.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190805
PL  - Germany
TA  - Eur J Appl Physiol
JT  - European journal of applied physiology
JID - 100954790
SB  - IM
MH  - Adult
MH  - *Cortical Excitability
MH  - Female
MH  - Humans
MH  - Male
MH  - Motor Cortex/*physiology
MH  - Muscle, Skeletal/innervation/*physiology
MH  - *Neural Inhibition
MH  - Physical Conditioning, Human/*methods
MH  - Pyramidal Tracts/*physiology
MH  - Transcranial Magnetic Stimulation
OTO - NOTNLM
OT  - Agonist
OT  - Antagonist
OT  - Corticospinal excitability
OT  - Corticospinal silent period
OT  - Intracortical facilitation
OT  - Short-interval cortical inhibition
OT  - Strength training
EDAT- 2019/08/07 06:00
MHDA- 2020/02/07 06:00
CRDT- 2019/08/07 06:00
PHST- 2019/06/11 00:00 [received]
PHST- 2019/07/31 00:00 [accepted]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2020/02/07 06:00 [medline]
PHST- 2019/08/07 06:00 [entrez]
AID - 10.1007/s00421-019-04203-9 [pii]
AID - 10.1007/s00421-019-04203-9 [doi]
PST - ppublish
SO  - Eur J Appl Physiol. 2019 Oct;119(10):2185-2199. doi: 10.1007/s00421-019-04203-9. 
      Epub 2019 Aug 5.