PMID- 31385202
OWN - NLM
STAT- MEDLINE
DCOM- 20210618
LR  - 20210618
IS  - 1559-0720 (Electronic)
IS  - 0163-4984 (Linking)
VI  - 194
IP  - 2
DP  - 2020 Apr
TI  - Effects of Choline and Magnesium Concurrent Supplementation on Coagulation and 
      Lipid Profile in Patients with Type 2 Diabetes Mellitus: a Pilot Clinical Trial.
PG  - 328-335
LID - 10.1007/s12011-019-01802-7 [doi]
AB  - Metabolic failure is associated with dyslipidemia and coagulation which can 
      result in a higher risk of cardiovascular disease (CVD) in type 2 diabetes 
      mellitus (T2DM). The aim of this study was to assess the effects of choline and 
      magnesium co-supplementation on lipid profile and coagulation parameters in 
      patients with T2DM. In a randomized, double-blind, placebo-controlled trial, 
      supplements of choline bitartrate (1000 mg), magnesium oxide (500 mg), choline 
      plus magnesium, or placebo were administered for 2 months to 96 diabetic 
      participants of both sexes aged 30-60 years. Anthropometric characteristics, 
      dietary intake, physical activity, serum lipids, and coagulation markers were 
      measured in all subjects. Significant differences were observed in plasminogen 
      activator inhibitor-1 (PAI-1) levels in the magnesium and choline-magnesium 
      groups (p < 0.05). Moreover, tissue plasminogen activator (tPA) levels increased 
      in choline-magnesium groups (p < 0.001). When adjusted for potential confounders, 
      a significant decrease in PAI-1 (p = 0.03) and a marginally significant increase 
      in tPA (p = 0.054) were found in the choline-magnesium group compared with the 
      other groups. Compared with baseline values, there were significant differences 
      in serum magnesium, HDL, and triglycerides (TG) following choline-magnesium 
      co-supplementation (p < 0.05); however, there were no significant differences in 
      serum magnesium, HDL, and TG among the groups (p > 0.05). Overall, concurrent 
      supplementation of magnesium and choline is more effective than either magnesium 
      or choline alone to improve coagulation in subjects with T2DM.
FAU - Rashvand, Samaneh
AU  - Rashvand S
AD  - Nutrition Research Center, Student Research Committee, School of Nutrition and 
      Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Mobasseri, Majid
AU  - Mobasseri M
AD  - Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
FAU - Tarighat-Esfanjani, Ali
AU  - Tarighat-Esfanjani A
AD  - Nutrition Research Center, School of Nutrition and Food Sciences, Tabriz 
      University of Medical Sciences, Attar Nishabouri St., PO Box 14711, Tabriz, 
      5166614711, Iran. tarighata@tbzmed.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20190805
PL  - United States
TA  - Biol Trace Elem Res
JT  - Biological trace element research
JID - 7911509
RN  - 0 (Lipids)
RN  - EC 3.4.21.68 (Tissue Plasminogen Activator)
RN  - I38ZP9992A (Magnesium)
RN  - N91BDP6H0X (Choline)
SB  - IM
MH  - Choline
MH  - *Diabetes Mellitus, Type 2/drug therapy
MH  - Dietary Supplements
MH  - Double-Blind Method
MH  - Female
MH  - Humans
MH  - Lipids
MH  - *Magnesium
MH  - Male
MH  - Tissue Plasminogen Activator
OTO - NOTNLM
OT  - Choline
OT  - Coagulation
OT  - Diabetes
OT  - Dyslipidemia
OT  - Magnesium
EDAT- 2019/08/07 06:00
MHDA- 2021/06/22 06:00
CRDT- 2019/08/07 06:00
PHST- 2019/03/12 00:00 [received]
PHST- 2019/06/26 00:00 [accepted]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2021/06/22 06:00 [medline]
PHST- 2019/08/07 06:00 [entrez]
AID - 10.1007/s12011-019-01802-7 [pii]
AID - 10.1007/s12011-019-01802-7 [doi]
PST - ppublish
SO  - Biol Trace Elem Res. 2020 Apr;194(2):328-335. doi: 10.1007/s12011-019-01802-7. 
      Epub 2019 Aug 5.