PMID- 31385389
OWN - NLM
STAT- MEDLINE
DCOM- 20210616
LR  - 20210809
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 25
IP  - 3
DP  - 2020 Mar
TI  - Blood eosinophil count as a predictor of hospital length of stay in COPD 
      exacerbations.
PG  - 259-266
LID - 10.1111/resp.13660 [doi]
AB  - BACKGROUND AND OBJECTIVE: Airway inflammation accompanying exacerbations varies 
      among individuals with some having neutrophilic, while others showing 
      eosinophilic inflammation. This study assessed the cut-off values of blood 
      eosinophil count for identifying subjects with longer hospital length of stay 
      (LOS) with acute exacerbations of chronic obstructive pulmonary disease (AECOPD). 
      METHODS: Patients were recruited at presentation to the hospital with an AECOPD. 
      Complete blood picture with differential count was taken on admission. Patients 
      were treated with a standard course of systemic corticosteroid and antibiotic and 
      evaluated at 8 weeks post-exacerbation for lung function measurement and 6-min 
      walk. They were followed up in 1 year for any readmissions or mortality. Cut-off 
      values of eosinophils for assessment of longer LOS were calculated using receiver 
      operating characteristic (ROC) curve analysis. RESULTS: A total of 346 patients 
      with admission eosinophil count were included in the analysis (333 (96.2%) were 
      males; mean +/- SD age: 74.9 +/- 7.8 years; mean forced expiratory volume in 1 s 
      (FEV(1) ): 43.4 +/- 16.3% predicted). The median (interquartile range (IQR)) of the 
      absolute peripheral eosinophil count, percent eosinophil count and LOS were 0.11 
      (0.25) x 10(9) /L, 1 (3) % and 5 (7) days, respectively. Using the median LOS of 
      >/=5 days as the cut-off, ROC analysis of the cut-off value of eosinophil count 
      associated with longer LOS was at <2% (area under the curve (AUC): 0.666, 
      P < 0.001) while absolute eosinophil count was at <0.144 x 10(9) /L (AUC: 0.645, 
      P < 0.001). These eosinophil cut-off values could predict longer LOS independent 
      of age, lung function and previous hospital admissions, but had no association 
      with readmissions for AECOPD and mortality at 12 months. CONCLUSION: An 
      eosinophil value of <0.144 x 10(9) /L on admission or <2% was associated with 
      longer hospital LOS for AECOPD.
CI  - (c) 2019 Asian Pacific Society of Respirology.
FAU - Ko, Fanny W S
AU  - Ko FWS
AUID- ORCID: 0000-0001-8454-0087
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Chan, Ka Pang
AU  - Chan KP
AUID- ORCID: 0000-0002-8163-5846
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Ngai, Jenny
AU  - Ngai J
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Ng, So-Shan
AU  - Ng SS
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Yip, Wing Ho
AU  - Yip WH
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Ip, April
AU  - Ip A
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Chan, Tat-On
AU  - Chan TO
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
FAU - Hui, David S C
AU  - Hui DSC
AUID- ORCID: 0000-0003-4382-2445
AD  - SH Ho Research Center in Respiratory Diseases, Division of Respiratory Medicine, 
      Department of Medicine and Therapeutics, The Chinese University of Hong Kong, 
      Hong Kong.
LA  - eng
SI  - ClinicalTrials.gov/NCT02815761
PT  - Journal Article
DEP - 20190806
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
CIN - Respirology. 2020 Mar;25(3):230-231. PMID: 31468623
CIN - Respirology. 2021 May;26(5):504-506. PMID: 33660367
CIN - Respirology. 2021 May;26(5):504. PMID: 33660387
MH  - Aged
MH  - Aged, 80 and over
MH  - Area Under Curve
MH  - *Eosinophils
MH  - Female
MH  - Forced Expiratory Volume
MH  - Humans
MH  - *Length of Stay
MH  - Leukocyte Count
MH  - Male
MH  - Patient Readmission
MH  - Pulmonary Disease, Chronic Obstructive/*blood/physiopathology
MH  - ROC Curve
MH  - Survival Rate
MH  - *Symptom Flare Up
OTO - NOTNLM
OT  - airway inflammation
OT  - chronic obstructive pulmonary disease
OT  - eosinophils
OT  - exacerbations
EDAT- 2019/08/07 06:00
MHDA- 2021/06/17 06:00
CRDT- 2019/08/07 06:00
PHST- 2018/12/21 00:00 [received]
PHST- 2019/05/06 00:00 [revised]
PHST- 2019/06/27 00:00 [accepted]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2021/06/17 06:00 [medline]
PHST- 2019/08/07 06:00 [entrez]
AID - 10.1111/resp.13660 [doi]
PST - ppublish
SO  - Respirology. 2020 Mar;25(3):259-266. doi: 10.1111/resp.13660. Epub 2019 Aug 6.