PMID- 31387157
OWN - NLM
STAT- MEDLINE
DCOM- 20210622
LR  - 20210622
IS  - 1440-1843 (Electronic)
IS  - 1323-7799 (Linking)
VI  - 25
IP  - 6
DP  - 2020 Jun
TI  - Long-term clinical course and outcome of interstitial pneumonia with autoimmune 
      features.
PG  - 636-643
LID - 10.1111/resp.13665 [doi]
AB  - BACKGROUND AND OBJECTIVE: Idiopathic interstitial pneumonia (IIP) with autoimmune 
      features that does not fulfil connective tissue disease (CTD) criteria has been 
      recently defined as interstitial pneumonia with autoimmune features (IPAF). 
      However, its long-term clinical course and outcome are poorly understood. 
      METHODS: We included consecutive patients diagnosed with IIP (n = 586) or 
      CTD-related interstitial lung disease (CTD-ILD, n = 149). Some patients with IIP 
      were reclassified as IPAF based on recent guidelines. RESULTS: The median 
      follow-up period was 45 months. Among the IIP patients, 109 (18.6%) were 
      reclassified as IPAF. Compared to the non-IPAF-IIP group, the IPAF group had 
      slower diffusing capacity of the lung for carbon monoxide (DL(CO) ) and total 
      lung capacity declines, and more frequent CTD development during follow-up 
      periods. The prognosis of the IPAF was better than that of the non-IPAF-IIP and 
      similar to that of the CTD-ILD. IPAF was associated with better prognosis in the 
      IIP cohort on univariate but not on multivariate analysis. Usual interstitial 
      pneumonia (UIP) pattern, old age and low DL(CO) independently predicted mortality 
      in the IPAF group. CONCLUSION: Compared to the non-IPAF-IIP group, the IPAF group 
      had slower lung function declines and more frequent CTD development during 
      follow-up. Although the prognosis of IPAF group was better than that of 
      non-IPAF-IIP group and similar to that of CTD-ILD group, it showed poor prognosis 
      in patients with old age, UIP pattern, and low DL(CO) .
CI  - (c) 2019 Asian Pacific Society of Respirology.
FAU - Kim, Ho Cheol
AU  - Kim HC
AD  - Department of Pulmonary and Critical Care Medicine, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Lee, Joo Hee
AU  - Lee JH
AUID- ORCID: 0000-0002-5923-0586
AD  - Department of Pulmonary and Critical Care Medicine, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
FAU - Chae, Eun Jin
AU  - Chae EJ
AD  - Department of Radiology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Song, Joon Seon
AU  - Song JS
AD  - Department of Pathology, Asan Medical Center, University of Ulsan College of 
      Medicine, Seoul, Republic of Korea.
FAU - Song, Jin Woo
AU  - Song JW
AUID- ORCID: 0000-0001-5121-3522
AD  - Department of Pulmonary and Critical Care Medicine, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Republic of Korea.
LA  - eng
GR  - NRF-2016R1A2B4016318/National Research Foundation of Korea/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20190806
PL  - Australia
TA  - Respirology
JT  - Respirology (Carlton, Vic.)
JID - 9616368
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Connective Tissue Diseases/*physiopathology
MH  - Female
MH  - Humans
MH  - Idiopathic Interstitial Pneumonias/*physiopathology/*therapy
MH  - Lung/*physiopathology
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Prognosis
MH  - Respiratory Function Tests
OTO - NOTNLM
OT  - connective tissue disease-associated interstitial lung disease
OT  - idiopathic interstitial pneumonia
OT  - interstitial pneumonia with autoimmune features
OT  - prognosis
EDAT- 2019/08/07 06:00
MHDA- 2021/06/23 06:00
CRDT- 2019/08/07 06:00
PHST- 2019/02/06 00:00 [received]
PHST- 2019/06/11 00:00 [revised]
PHST- 2019/07/15 00:00 [accepted]
PHST- 2019/08/07 06:00 [pubmed]
PHST- 2021/06/23 06:00 [medline]
PHST- 2019/08/07 06:00 [entrez]
AID - 10.1111/resp.13665 [doi]
PST - ppublish
SO  - Respirology. 2020 Jun;25(6):636-643. doi: 10.1111/resp.13665. Epub 2019 Aug 6.