PMID- 31387820
OWN - NLM
STAT- MEDLINE
DCOM- 20201123
LR  - 20201123
IS  - 1874-1754 (Electronic)
IS  - 0167-5273 (Linking)
VI  - 298
DP  - 2020 Jan 1
TI  - Atrial fibrillation as a clinical characteristic of arrhythmogenic right 
      ventricular cardiomyopathy: Experience from the Nordic ARVC Registry.
PG  - 39-43
LID - S0167-5273(19)33134-1 [pii]
LID - 10.1016/j.ijcard.2019.07.086 [doi]
AB  - BACKGROUND: Recent studies in arrhythmogenic right ventricular cardiomyopathy 
      (ARVC) patients have drawn attention to atrial fibrillation (AF) as an arrhythmic 
      manifestation of ARVC and as an indicator of atrial involvement in the disease 
      progression. We aimed to assess the prevalence of AF in the Scandinavian cohort 
      of ARVC patients and to evaluate its association with disease clinical 
      manifestations. METHODS: Study sample comprised of 293 definite ARVC patients by 
      2010 Task Force criteria (TFC2010) and 141 genotype-positive family members 
      (total n = 434, 43% females, median age at ARVC diagnosis 41 years [interquartile 
      range (IQR) 28-52 years]). ARVC diagnostic score was calculated as the sum of 
      major (2 points) and minor (1 point) criteria in all categories of the TFC2010. 
      RESULTS: AF was diagnosed in 42 patients (10%): in 41 patients with definite ARVC 
      diagnosis (14%) vs in one genotype-positive family member (1%), p < 0.001. The 
      median age at AF onset was 51 (IQR 38-58) years. The prevalence of AF was related 
      to the ARVC diagnostic score: it significantly increased starting with the 
      diagnostic score 4 (2% in those with score 3 vs 13% in those with score 4, 
      p = 0.023) and increased further with increased diagnostic score (Somer's d value 
      is 0.074, p < 0.001). CONCLUSION: AF is seen in 14% of definite ARVC patients and 
      is related to the severity of disease phenotype thus suggesting AF being an 
      arrhythmic manifestation of this cardiomyopathy indicating atrial myocardial 
      involvement in the disease progression.
CI  - Copyright (c) 2019 Elsevier B.V. All rights reserved.
FAU - Baturova, Maria A
AU  - Baturova MA
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden; 
      Research Park, Saint Petersburg State University, Saint Petersburg, Russia. 
      Electronic address: Maria.Baturova@med.lu.se.
FAU - Haugaa, Kristina H
AU  - Haugaa KH
AD  - Center for Cardiological Innovation, Department of Cardiology, Oslo University 
      Hospital, Rikshospitalet, Oslo, Norway; Institute for Clinical Medicine, 
      University of Oslo, Oslo, Norway.
FAU - Jensen, Henrik K
AU  - Jensen HK
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark; Department 
      of Clinical Medicine, Health, Aarhus University, Aarhus, Denmark.
FAU - Svensson, Anneli
AU  - Svensson A
AD  - Department of Cardiology and Department of Medical and Health Sciences, Linkoping 
      University, Linkoping, Sweden.
FAU - Gilljam, Thomas
AU  - Gilljam T
AD  - Department of Cardiology, Sahlgrenska University Hospital, Gothenburg, Sweden.
FAU - Bundgaard, Henning
AU  - Bundgaard H
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark; 
      Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Madsen, Trine
AU  - Madsen T
AD  - Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
FAU - Hansen, Jim
AU  - Hansen J
AD  - Department of Cardiology, Herlev-Gentofte Hospital, University of Copenhagen, 
      Copenhagen, Denmark.
FAU - Chivulescu, Monica
AU  - Chivulescu M
AD  - Center for Cardiological Innovation, Department of Cardiology, Oslo University 
      Hospital, Rikshospitalet, Oslo, Norway; Institute for Clinical Medicine, 
      University of Oslo, Oslo, Norway.
FAU - Christiansen, Morten Krogh
AU  - Christiansen MK
AD  - Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
FAU - Carlson, Jonas
AU  - Carlson J
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
FAU - Edvardsen, Thor
AU  - Edvardsen T
AD  - Center for Cardiological Innovation, Department of Cardiology, Oslo University 
      Hospital, Rikshospitalet, Oslo, Norway; Institute for Clinical Medicine, 
      University of Oslo, Oslo, Norway.
FAU - Svendsen, Jesper H
AU  - Svendsen JH
AD  - Department of Cardiology, The Heart Center, Rigshospitalet, Copenhagen, Denmark; 
      Department of Clinical Medicine, Faculty of Health and Medical Sciences, 
      University of Copenhagen, Copenhagen, Denmark.
FAU - Platonov, Pyotr G
AU  - Platonov PG
AD  - Department of Cardiology, Clinical Sciences, Lund University, Lund, Sweden.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20190730
PL  - Netherlands
TA  - Int J Cardiol
JT  - International journal of cardiology
JID - 8200291
SB  - IM
CIN - Int J Cardiol. 2020 Jan 1;298:54. PMID: 31522767
MH  - Adult
MH  - Arrhythmogenic Right Ventricular 
      Dysplasia/diagnosis/*epidemiology/*physiopathology
MH  - Atrial Fibrillation/diagnosis/*epidemiology/*physiopathology
MH  - Cohort Studies
MH  - Electrocardiography/methods
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - *Registries
MH  - Scandinavian and Nordic Countries/epidemiology
OTO - NOTNLM
OT  - Arrhythmogenic cardiomyopathy
OT  - Atrial fibrillation
OT  - Diagnostic score
EDAT- 2019/08/08 06:00
MHDA- 2020/11/24 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/06/19 00:00 [received]
PHST- 2019/07/15 00:00 [revised]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/11/24 06:00 [medline]
PHST- 2019/08/08 06:00 [entrez]
AID - S0167-5273(19)33134-1 [pii]
AID - 10.1016/j.ijcard.2019.07.086 [doi]
PST - ppublish
SO  - Int J Cardiol. 2020 Jan 1;298:39-43. doi: 10.1016/j.ijcard.2019.07.086. Epub 2019 
      Jul 30.