PMID- 31388753
OWN - NLM
STAT- MEDLINE
DCOM- 20200430
LR  - 20200430
IS  - 1432-1750 (Electronic)
IS  - 0341-2040 (Linking)
VI  - 197
IP  - 5
DP  - 2019 Oct
TI  - The Frequency of Monocyte Chemoattractant Protein-1 Gene Polymorphism in 
      Obstructive Sleep Apnea Syndrome.
PG  - 585-592
LID - 10.1007/s00408-019-00256-x [doi]
AB  - PURPOSE: In obstructive sleep apnea syndrome (OSAS) many proinflammatory 
      cytokines are released from activated endothelial cells due to repeated decreases 
      in arterial oxygen saturation. Some of these proinflammatory cytokines are 
      involved in the etiology of coronary artery disease (CAD). Although the 
      association between OSAS and CAD is known, risk factors for CAD have not been 
      determined in this patient group. Monocyte chemoattractant protein-1 (MCP-1) is a 
      proinflammatory cytokine that plays a key role in the development of 
      atherosclerosis. In this study, we compared the frequency of MCP1 
      rs1024610-rs1024611 single-nucleotide polymorphisms (SNPs) in OSAS patients with 
      no comorbidity, OSAS patients with no comorbidity except CAD, and healthy 
      individuals. MATERIAL AND METHODS: The study included 301 subjects. Two hundred 
      one patients with OSAS (OSAS only and OSAS + CAD groups) and 100 healthy control 
      subjects underwent polysomnography. MCP1 rs1024610 and rs1024611 mutation 
      frequencies were determined. RESULTS: Body mass index, apnea-hypopnea index, 
      triglyceride levels, and mean oxygen desaturation were significantly higher in 
      the OSAS patients than in the healthy population (p < 0.05). In MCP1 rs1024611 
      SNP analysis, homozygous mutation was significantly more common in the OSAS + CAD 
      group than in the OSAS and control groups (p < 0.001). MCP1 rs1024610 SNP 
      analysis showed no significant differences among the study groups. CONCLUSION: 
      OSAS patients with homozygous MCP1 rs1024611 SNP are at higher risk for CAD. The 
      MCP1 rs1024610 SNP was not associated with incidence of CAD. Patients with OSAS 
      and MCP1 rs1024611 homozygous mutation are more susceptible to CAD and early 
      detection and treatment may significantly reduce mortality and morbidity.
FAU - Kerget, Bugra
AU  - Kerget B
AUID- ORCID: 0000-0002-6048-1462
AD  - Department of Pulmonary Diseases, Health Sciences University Erzurum, Regional 
      Education and Research Hospital, Erzurum, Turkey. bjkerget1903@gmail.com.
AD  - Pulmonology Department, Health Sciences University Erzurum, Regional Education 
      and Research Hospital, Yakutiye, 25240, Erzurum, Turkey. bjkerget1903@gmail.com.
FAU - Araz, Omer
AU  - Araz O
AD  - Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, 
      Erzurum, Turkey.
FAU - Erdem, Haktan Bagis
AU  - Erdem HB
AD  - Medical Genetics Unit, Health Sciences University, Diskapi Yildirim Beyazit 
      Training and Research Hospital, Ankara, Turkey.
FAU - Akgun, Metin
AU  - Akgun M
AD  - Department of Pulmonary Diseases, Ataturk University School of Medicine, 25240, 
      Erzurum, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20190806
PL  - United States
TA  - Lung
JT  - Lung
JID - 7701875
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Case-Control Studies
MH  - Chemokine CCL2/*genetics
MH  - Coronary Artery Disease/diagnosis/epidemiology/*genetics
MH  - Female
MH  - Genetic Association Studies
MH  - Genetic Predisposition to Disease
MH  - Heterozygote
MH  - Homozygote
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Mutation
MH  - Mutation Rate
MH  - Phenotype
MH  - *Polymorphism, Single Nucleotide
MH  - Risk Assessment
MH  - Risk Factors
MH  - Sleep Apnea, Obstructive/diagnosis/epidemiology/*genetics
MH  - Turkey/epidemiology
OTO - NOTNLM
OT  - Atherosclerosis
OT  - Coronary arterial diseases
OT  - Monocyte chemoattractant protein-1
OT  - Obstructive sleep apnea syndrome
EDAT- 2019/08/08 06:00
MHDA- 2020/05/01 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/04/16 00:00 [received]
PHST- 2019/07/29 00:00 [accepted]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/05/01 06:00 [medline]
PHST- 2019/08/08 06:00 [entrez]
AID - 10.1007/s00408-019-00256-x [pii]
AID - 10.1007/s00408-019-00256-x [doi]
PST - ppublish
SO  - Lung. 2019 Oct;197(5):585-592. doi: 10.1007/s00408-019-00256-x. Epub 2019 Aug 6.