PMID- 31388950
OWN - NLM
STAT- MEDLINE
DCOM- 20231006
LR  - 20231006
IS  - 1614-7499 (Electronic)
IS  - 0944-1344 (Linking)
VI  - 26
IP  - 28
DP  - 2019 Oct
TI  - Maternal exposure to environmentally relevant doses of bisphenol A causes 
      reproductive dysfunction in F1 adult male rats: protective role of melatonin.
PG  - 28940-28950
LID - 10.1007/s11356-019-06153-3 [doi]
AB  - This study investigated the protective effects of melatonin (MLT), a potent 
      antioxidant, in male Wistar rats exposed to environmentally relevant doses of 
      bisphenol A (BPA) in utero. Pregnant Wistar rats were randomly assigned into five 
      groups. Group 1 (control) received 0.2 mL 1% dimethyl sulfoxide (DMSO)/99% canola 
      oil as vehicle; group 2 received BPA at 25 mug/kg/day; group 3 received BPA at 250 
      mug/kg/day; group 4 received BPA at 25 mug/kg/day with concurrent MLT 1 mg/kg/day 
      while group 5 received BPA at 250 mug/kg/day with concurrent MLT 1 mg/kg/day. 
      Treatments were by gavage from gestational day (GD) 10-21. The BPA-treated rats 
      showed dose-dependent significant reduction in body weight, gonosomatic index, 
      sperm motility, livability and count. Also, BPA caused significant reduction in 
      the levels of serum testosterone and luteinizing hormone while it caused 
      significant increases in the levels of follicle stimulating hormone as well as 
      estradiol. Furthermore, BPA induced testicular oxidative stress including 
      significant decreases in the activities of testicular SOD, GSH and GPx as well as 
      GST, increasing the levels of testicular MDA and H(2)O(2). It further induced 
      interstitial necrosis and germinal cell degeneration in the testis with a 
      subsequent diminution of the tubular and luminal diameter. However, co-treatment 
      with MLT offered protection against testicular damage induced by BPA. Melatonin 
      is likely to protect against alterations of the male reproductive system caused 
      by BPA through a direct action on the mechanism of anti-oxidants as well as 
      through the inhibition of necrosis.
FAU - Olukole, Samuel Gbadebo
AU  - Olukole SG
AUID- ORCID: 0000-0003-2260-3286
AD  - Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria. 
      deborolukole@yahoo.com.
FAU - Lanipekun, Damilare Olaniyi
AU  - Lanipekun DO
AD  - Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
FAU - Ola-Davies, Eunice Olufunke
AU  - Ola-Davies EO
AD  - Department of Veterinary Physiology and Biochemistry, University of Ibadan, 
      Ibadan, Nigeria.
FAU - Oke, Bankole Olusiji
AU  - Oke BO
AD  - Department of Veterinary Anatomy, University of Ibadan, Ibadan, Nigeria.
LA  - eng
PT  - Journal Article
DEP - 20190806
PL  - Germany
TA  - Environ Sci Pollut Res Int
JT  - Environmental science and pollution research international
JID - 9441769
RN  - 0 (Antioxidants)
RN  - 0 (Benzhydryl Compounds)
RN  - MLT3645I99 (bisphenol A)
RN  - 4TI98Z838E (Estradiol)
RN  - 9002-68-0 (Follicle Stimulating Hormone)
RN  - BBX060AN9V (Hydrogen Peroxide)
RN  - 9002-67-9 (Luteinizing Hormone)
RN  - JL5DK93RCL (Melatonin)
RN  - 0 (Phenols)
RN  - 0 (Protective Agents)
RN  - 3XMK78S47O (Testosterone)
SB  - IM
MH  - Animals
MH  - Female
MH  - Male
MH  - Pregnancy
MH  - Rats
MH  - *Antioxidants/pharmacology
MH  - *Benzhydryl Compounds/chemistry/toxicity
MH  - Estradiol/chemistry/pharmacology
MH  - Follicle Stimulating Hormone/blood
MH  - *Hydrogen Peroxide/analysis/chemistry/pharmacology
MH  - *Luteinizing Hormone/blood
MH  - Maternal Exposure
MH  - *Melatonin/chemistry/pharmacology
MH  - *Phenols/chemistry/toxicity
MH  - *Protective Agents/chemistry/pharmacology
MH  - Random Allocation
MH  - Rats, Wistar
MH  - *Sperm Motility/drug effects
MH  - Testis/drug effects
MH  - *Testosterone/blood
OTO - NOTNLM
OT  - Antioxidant
OT  - Gestational BPA
OT  - Melatonin
OT  - Oxidative stress
OT  - Testicular damage
EDAT- 2019/08/08 06:00
MHDA- 2020/01/17 06:00
CRDT- 2019/08/08 06:00
PHST- 2019/02/07 00:00 [received]
PHST- 2019/07/31 00:00 [accepted]
PHST- 2019/08/08 06:00 [pubmed]
PHST- 2020/01/17 06:00 [medline]
PHST- 2019/08/08 06:00 [entrez]
AID - 10.1007/s11356-019-06153-3 [pii]
AID - 10.1007/s11356-019-06153-3 [doi]
PST - ppublish
SO  - Environ Sci Pollut Res Int. 2019 Oct;26(28):28940-28950. doi: 
      10.1007/s11356-019-06153-3. Epub 2019 Aug 6.